Approaches towards the synthesis of 5-aminopyrazoles

• Ranjana Aggarwal,
• Vinod Kumar,
• Rajiv Kumar and
• Shiv P. Singh

Beilstein J. Org. Chem. 2011, 7, 179–197, doi:10.3762/bjoc.7.25

• this reaction and the 3-aminopyrazole intermediate 136 was obtained in excellent yield (93%) as a single isomer. The new derivatives 137 were shown to inhibit intracellular phosphorylation of hsp27 as well as LPS-induced TNFa release in cells (Scheme 37) [79]. The potassium salt of ethyl cyanopyruvate

• hsp27-phosphorylation and TNFa-release. Synthesis of the diglycylpyrazole 142. Synthesis of 5-amino-1-aryl-4-benzoylpyrazole derivatives. Synthesis of 4-benzoyl-3,5-diamino-1-(2-cyanoethyl)pyrazole. Synthesis of the 5-aminopyrazole derivative 150. Synthesis of 3,5-diaminopyrazoles 153. Synthesis of 5

Novel 2-(ω-phosphonooxy-2-oxaalkyl)acrylate monomers for self-etching self-priming one part adhesive

• Joachim E. Klee and
• Uwe Lehmann

Beilstein J. Org. Chem. 2010, 6, 766–772, doi:10.3762/bjoc.6.95

• acrylate and formaldehyde, and subsequent etherification of the obtained product with diols and phosphorylation using POCl3. The polymerization enthalpy of 2-(ω-phosphonooxy-2-oxaalkyl)acrylates 3 as measured by DSC ranges from −29 to −53 kJ·mol−1. The shear bond strength of adhesive compositions 4

• , comprising of polymerizable acids 3, ranges from 5.8 to 19.3 MPa on enamel and from 8.7 to 16.9 MPa on dentin. Keywords: adhesion to enamel and dentin; hydrolysis stable 2-(ω-phosphonooxy-2-oxaalkyl)acrylates; phosphorylation using POCl3; polymerization enthalpy; shear bond strength; Introduction Dental

• , comprising of phosphoric acid ester moieties, were synthesized via a three step synthesis via Baylis–Hillman reaction of ethyl acrylate and formaldehyde, and subsequent etherification of the obtained product with diols and phosphorylation using POCl3 (Scheme 1, Table 1). The double bonds in 3 are evident in

Synthesis of 6-PEtN-α-D-GalpNAc-(1–>6)-β-D-Galp-(1–>4)-β-D-GlcpNAc-(1–>3)-β-D-Galp-(1–>4)-β-D-Glcp, a Haemophilus influenzae lipopolysacharide structure, and biotin and protein conjugates thereof

• Andreas Sundgren,
• Martina Lahmann and
• Stefan Oscarson

Beilstein J. Org. Chem. 2010, 6, 704–708, doi:10.3762/bjoc.6.80

• -neotetraose structure that we have experience of from, i.a., former synthetic work related to Streptococcus pneumoniae type 14 CPS structures [11]. To allow for the introduction of the GalNAc residue at the 6IV-position and the subsequent phosphorylation of the 6V-hydroxy group, two new galactosyl donors were

• thioglycoside 4 [14] yielded the 6-O-silylated compound 5 (92%), benzylation of which gave donor 6 (85%). A benzyl group in the 4-position was preferred to an ester group to avoid the risk of acyl migration during subsequent reactions; desilylation, glycosidation and phosphorylation. 3II,4II-Diols of lactose

• phosphorylation step. Activation of 21 with pivaloyl chloride in the presence of 19 afforded the H-phosphonate diester, which was oxidised with I2/pyridine in water to afford the phosphate diester 22 [30]. Deprotection with sodium methoxide followed by catalytic hydrogenolysis then afforded the still Boc

(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study

• Kazuhiko Nakamura,
• Yu Tachikawa and
• Daisuke Uemura

Beilstein J. Org. Chem. 2009, 5, No. 12, doi:10.3762/bjoc.5.12

• . These results suggest that complanine can bind PKC at the same site as phosphatidylserine, a co-activation factor with Ca2+ and TPA. It is known that signal transduction leads to an inflammation mediator TNF-α and its downstream signal molecules, which occurs by phosphorylation through the action of PKC

N-1 regioselective Michael- type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate

• Sławomir Boncel,
• Dominika Osyda and
• Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2007, 3, No. 40, doi:10.1186/1860-5397-3-40

• literature for acyclic nucleosides.[1] Acyclic units containing hydroxyl groups are capable of phosphorylation and building into a growing nucleic acid, thus perturbing its replication. Several acyclic nucleosides, like HEPT (1-[2-hydroxyethoxymethyl]-6-(phenylthio)thymine),[2] or MKC-442 (1-ethoxymethyl-5