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Search for "phostone" in Full Text gives 2 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of medium and large phostams, phostones, and phostines

  • Jiaxi Xu

Beilstein J. Org. Chem. 2023, 19, 687–699, doi:10.3762/bjoc.19.50

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  • of two ring bonds. This review includes the recent syntheses of seven to fourteen-membered phostam, phostone, and phostine derivatives. Keywords: azaphosphaheterocycle; oxaphosphaheterocycle; phostam; phostine; phostone; Introduction Phostams, phostones, and phostines are a class of important
  • prepared, while numerous five-membered γ-phostams [11][12], γ-phostones and γ-phostines [13], and six-membered δ-phostams [14][15][16], δ-phostones [17][18] and δ-phostines [17][19][20] have been synthesized via various synthetic strategies. In comparison with common ring size phostam, phostone, and
  • phostine derivatives, less attention has been paid to the synthesis of medium and large phostam, phostone, and phostine derivatives. They are also biologically active compounds, such as inhibitors of the human farnesyl pyrophosphate synthase [21][22], antitumor agents [23], and hapten for the production of
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Published 15 May 2023

Synthesis of phosphonate and phostone analogues of ribose-1-phosphates

  • Pitak Nasomjai,
  • David O'Hagan and
  • Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2009, 5, No. 37, doi:10.3762/bjoc.5.37

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  • fluorometabolism in S. cattleya. Keywords: 5-fluoro-5-deoxyribose-1-phosphate; fluorometabolite biosynthesis; phosphonates; phostone; ribose-1-phosphate; Introduction Fluoroacetate (1) and 4-fluorothreonine (2) are unusual secondary metabolites in that they contain a fluorine atom. They are elaborated by the
  • biosynthesis system, and as inert candidate substrate analogues for enzyme co-crystallisation studies. We also report the synthesis of the cyclic phostone analogues 10 and 11 (Figure 1), which were viewed also as potential substrate analogues for co-crystallisation studies, particularly with the isomerase
  • ] to generate the cyclic phostones 10 and 11 respectively. In each case this conversion could be conveniently followed by a change in the 31P-NMR resonance of 27 ppm (phosphonate) to 44 ppm, characteristic of a cyclic phostone. Purification by chromatography allowed the recovery of the phostones 10 and
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Published 27 Jul 2009
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