Beilstein J. Org. Chem.2021,17, 2663–2667, doi:10.3762/bjoc.17.180
obtained 3,3-diarylpropenenitriles in triflic acid CF3SO3H (TfOH) at room temperature for 1 h are cyclized into 3-arylindenones in yields of 55–70%.
Keywords: aluminum bromide; hydroarylation; indenones; propenenitriles; propynenitriles; Introduction
Conjugated acetylene nitriles (propynenitriles, R–C≡C
–C≡N) are versatile building blocks in organic synthesis for the preparation of a plethora of functionalized compounds and heterocycles. The presence of conjugated acetylene and nitrile bonds in these compounds leads to an enhancement of reactivity of both functional groups. Thus, propynenitriles
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Graphical Abstract
Scheme 1:
AlBr3-promoted hydroarylation of the acetylene bond of 3-arylpropynenitriles 1a–c by arenes with th...