Exploring the scope of DBU-promoted amidations of 7-methoxycarbonylpterin

• Anna R. Bockman and
• Jeffrey M. Pruet

Beilstein J. Org. Chem. 2020, 16, 509–514, doi:10.3762/bjoc.16.46

• yields often >80%. Keywords: amidation; DBU; folate; pterin; Introduction Pteridines are a class of fused bicyclic heterocycles with significant biological relevance. The 2-amino-4-pteridinone core, simply referred to as “pterin”, is present in various biological cofactors like folates, biopterin, and

• , pterins have been a useful scaffold in the development of inhibitors of ricin [3][4], methionine synthase [5], nitric oxide synthase [6], shigella [7], and aldose reductase [8], as well as for treatment of leishmaniosis [9]. In addition to their therapeutic potential, pterin derivatives have been an

• new pterins. As such, any reaction which expedites the synthesis of pterin derivatives, especially those which bypass the insolubility, is of great importance to both medicinal and supramolecular chemists. We first reported the application of DBU as a crucial additive in the synthesis of pterins used

Biocatalysis for the application of CO₂ as a chemical feedstock

• Apostolos Alissandratos and
• Christopher J. Easton

Beilstein J. Org. Chem. 2015, 11, 2370–2387, doi:10.3762/bjoc.11.259

• CO2. Autotrophic acetogen FDHs are usually bound to metallo-pterin cofactors, with either a Mo or W centre [55][62][63], coordinated to a SeCys or Cys ligand. These features are not limited to acetogenic FDHs, and Mo and W FDHs are broadly distributed throughout the bacterial kingdom [63][64][65][66