Beilstein J. Org. Chem.2023,19, 1155–1160, doi:10.3762/bjoc.19.83
when irradiated with UV light.
Keywords: 5-aminopyrazole; azlactone; elimination; fluorescence; one-pot synthesis; pyrazolo[3,4-b]pyridin-6-one; Introduction
The pyrazolo[3,4-b]pyridine scaffold is present in many biologically active compounds [1][2][3][4][5][6][7][8][9][10][11][12]. Among them, 4
obtained under solvent-free conditions followed by the addition of t-BuOK in DMSO, the yield of pyrazolo[3,4-b]pyridin-6-one 4a was higher (73%, Table 1, entry 5) than when performing the reaction in a solvent (60%, Table 1, entry 6). Therefore, this procedure was used for the synthesis of compounds 4b–i
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Graphical Abstract
Figure 1:
Biologically active 4-arylpyrazolo[3,4-b]pyridin-6-ones.