Beilstein J. Org. Chem.2021,17, 2787–2794, doi:10.3762/bjoc.17.189
of natural product-like compound libraries.
Keywords: [bis(trifluoroacetoxy)iodo]benzene PIFA; nitrogen heterocycles; oxidative cyclization; pyrrolo[1,2-a]quinazolines; Introduction
An important design concept in current drug discovery includes structural modifications of naturally occurring
chemistry, and this approach has already provided successful results in the view of reaching biological activity. Thus, angular pyrrolo[1,2-a]quinazolines of type 1 – analogs of naturally occurring vasicinone alkaloids bearing an isomeric linear pyrrolo[2,1-b]quinazoline core [5][6][7][8] – demonstrated
PDF
Graphical Abstract
Figure 1:
Pyrrolo[1,2-a]quinazoline derivatives – analogs of vasicinone alkaloids and their biological activi...