Beilstein J. Org. Chem.2019,15, 2840–2846, doi:10.3762/bjoc.15.277
: condensation; dihydropyrrolone derivative; one-pot synthesis; pyrrolo[3,4-b]pyridine-4,5-diones; recyclization; Introduction
Derivatives of pyrrolo[3,4-b]pyridin-5-one are known for their broad-spectrum biological activity [1][2][3]. One example includes a family of compounds based on this fragment that was
strongly desirable.
In this article, we describe a convenient synthetic method for the preparation of 6-alkyl-2-methyl-7-aryl-6,7-dihydro-1H-pyrrolo[3,4-b]pyridine-4,5-diones 1. Therein, the condensation of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides 2 with a diverse range of