Beilstein J. Org. Chem.2018,14, 884–890, doi:10.3762/bjoc.14.75
Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China 10.3762/bjoc.14.75 Abstract A straightforward and one-pot synthesis of pyrrolo[3,4-c]pyrrole-1,3-diones via Ag(I)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with N-alkyl maleimide, followed by readily
substrates. It is conceivable that this efficient construction method for privileged pyrrole scaffolds could deliver more active compounds for medicinal chemistry research.
Keywords: azomethine ylides; 1,3-dipolar cycloaddition; one-pot synthesis; polysubstituted pyrroles; pyrrolo[3,4-c]pyrrole-1,3-diones
; Introduction
Pyrroles are an important class of five-membered nitrogen containing heterocycles which are widely used in numerous medically relevant fields. Pyrrolo[3,4-c]pyrrole-1,3-diones and highly substituted pyrroles with amide groups are important frameworks of pyrrole compounds that play important roles
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Graphical Abstract
Figure 1:
Representative pyrrolo[3,4-c]pyrrole-1,3-diones and polysubstituted pyrrole derivatives.