A heteroditopic macrocycle as organocatalytic nanoreactor for pyrroloacridinone synthesis in water

• Piyali Sarkar,
• Sayan Sarkar and
• Pradyut Ghosh

Beilstein J. Org. Chem. 2019, 15, 1505–1514, doi:10.3762/bjoc.15.152

• synthesis of diversely functionalized pyrroloacridinones in aqueous medium. A library of compounds was synthesized in a one-step pathway utilizing 10 mol % of the nanoreactor following a sustainable methodology in water with high yields. Keywords: heteroditopic macrocycle; organocatalyst; nanoreactor

• ; pyrroloacridinones; sustainable chemistry; water; Introduction Acridines are a renowned heterocyclic entity not only for their biological activities but also for their fluorescence and chemiluminescence properties. Acridine dyes (e.g., acridine orange, acridine yellow, etc.), are predominantly used in staining of

• pyrroloacridinones The organocatalytic activity of the BATA-MC nanoreactor was then explored in the synthesis of pyrroloacridines. To optimize the reaction conditions, we chose the synthesis of 4a as the model reaction. Thus, we performed the reaction of isatin (1a, 1 mmol), 5,5-dimethylcyclohexane-1,3-dione (2, 1