Knorr- Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids

• Brendon S. Gourlay,
• John H. Ryan and
• Jason A. Smith

Beilstein J. Org. Chem. 2008, 4, No. 3, doi:10.1186/1860-5397-4-3

• intermediate. Donohoe's approach to (±)-1-epiaustraline utilising a modified Birch reduction. Reaction conditions i) Zn, HCl (aq). Reaction conditions: i) ref. [10] ii) ref. [11] iii) Zn, conc. HCl(aq). Potential mechanism for α-ketopyrrole reduction.. Alternative reduction pathway. Catalytic hydrogenation