A practical microreactor for electrochemistry in flow

• Kevin Watts,
• William Gattrell and
• Thomas Wirth

Beilstein J. Org. Chem. 2011, 7, 1108–1114, doi:10.3762/bjoc.7.127

• platinum electrodes with a surface area of 45 mm2 were positioned with an inter-electrode gap of either 160 µm or 320 µm, and C–C bond forming reactions based on the electro-reductive coupling of activated olefins and benzyl bromide derivatives were reported. The best result obtained was a 98% formation of

Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles

• Peter Wipf and
• Marija D. Manojlovic

Beilstein J. Org. Chem. 2011, 7, 824–830, doi:10.3762/bjoc.7.94

• article, we report a one-pot hydrozirconation of allenes and nitriles that facilitates the reductive coupling to yield N-unprotected homoallylic amines. Results and Discussion We first investigated the addition of allylzirconocenes to N-aluminoimines. N-aluminoisobutyroimine 1 was prepared in situ by the

• protocol for the reductive coupling of allenes and alkynes [38], led to the formation of homoallylic amine 8 in 75% yield after stirring at room temperature for 3 h. Under the optimized conditions for the reaction of benzonitrile (7), we further explored the scope of the reaction of nitriles with 2 (Table

• to that of the zinca-Claisen reaction observed by Suzuki and co-workers [38]. Analogous to the previous work in our group [15], the silyl-substituted allene 16 produced the (E)-vinylsilane 17 as the sole product in this reaction. Given the success of the one-pot intermolecular reductive coupling of

Chiral trimethylsilylated C₂-symmetrical diamines as phosphorous derivatizing agents for the determination of the enantiomeric excess of chiral alcohols by ¹H NMR

• Anne-Sophie Chauvin and
• Alexandre Alexakis

Beilstein J. Org. Chem. 2006, 2, No. 6, doi:10.1186/1860-5397-2-6

• [30]. (R,R)-1,2-diphenyl-N,N'-bis-trimethylsilanylmethyl-ethane-1,2-diamine 2 was prepared by the same method, starting from (R,R)-diphenyl-ethane-1,2-diamine 5 (Scheme 2) [31]. N,N'-Dimethyl-1,2-bis-(3-trimethylsilanyl-phenyl)-ethane-1,2-diamine 3 was synthesised by reductive coupling of methyl-(3