Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases

• Julia N. Artsemyeva,
• Ekaterina A. Remeeva,
• Tatiana N. Buravskaya,
• Irina D. Konstantinova,
• Roman S. Esipov,
• Anatoly I. Miroshnikov,
• Natalia M. Litvinko and
• Igor A. Mikhailopulo

Beilstein J. Org. Chem. 2020, 16, 2607–2622, doi:10.3762/bjoc.16.212

• letter to the editor Kalckar reported for the first time that specific inosine nucleosidase from rat liver catalyzes the reversible reaction “inosine + phosphate ⇌ hypoxanthine + ribose-1-phosphate”: the equilibrium of this reaction in water at pH 6.5 is displaced to the nucleoside synthesis. Moreover

• , he made the very interesting observation that the reaction of hypoxanthine and ribose-1-phosphate reached equilibrium after 20 min at a 70% concentration of inosine and “The synthesis of inosine would probably proceed further if all traces of inorganic phosphate were removed, since with equimolar

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

• Mikhail V. Makarov and
• Marie E. Migaud

Beilstein J. Org. Chem. 2019, 15, 401–430, doi:10.3762/bjoc.15.36

• enzymatic synthesis of NR+ from α-D-ribose-1-phosphate and Nam by catalysis with purine nucleoside phosphorylase and sucrose phosphorylase is described in a US patent application by Velasquez et al. [46]. In the NMR experiments, the authors demonstrated the preparation of NR+ but did not isolate pure NR+. 3

Synthesis of phosphonate and phostone analogues of ribose-1-phosphates

• Pitak Nasomjai,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2009, 5, No. 37, doi:10.3762/bjoc.5.37

• Pitak Nasomjai David O'Hagan Alexandra M. Z. Slawin School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK 10.3762/bjoc.5.37 Abstract The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1

• fluorometabolism in S. cattleya. Keywords: 5-fluoro-5-deoxyribose-1-phosphate; fluorometabolite biosynthesis; phosphonates; phostone; ribose-1-phosphate; Introduction Fluoroacetate (1) and 4-fluorothreonine (2) are unusual secondary metabolites in that they contain a fluorine atom. They are elaborated by the

• both 5′-FDA and adenosine, and thus the presence or absence of fluorine at the C-5′-position is not a requisite for catalysis. The next enzymatic step involves a ring opening isomerisation of the ribose-1-phosphate 5. In this paper we report the synthesis of phosphonate analogues 8 and 9 of ribose-1