Magnesium bis(monoperoxyphthalate) hexahydrate as mild and efficient oxidant for the synthesis of selenones

• Andrea Temperini,
• Massimo Curini,
• Ornelio Rosati and
• Lucio Minuti

Beilstein J. Org. Chem. 2014, 10, 1267–1271, doi:10.3762/bjoc.10.127

• Abstract A new, efficient and mild method for the direct oxidation of selenides to selenones using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) has been developed. Noteworthy this transformation proceeds at room temperature, employs a cheap and safety oxidant and has a broad functional group

• tolerance. Moreover, the produced selenones could be useful intermediates for the synthesis of different heterocyclic compounds. Keywords: heterocycles; monoperoxyphthalate; oxidation; selenides; selenones; Introduction Organoselenium compounds have received considerable attention in recent times because

• they are versatile reagents or intermediates in organic synthesis [1]. Particularly, alkyl phenyl selenones [2][3] represent a valuable compound class due to the ability of the phenylselenonyl group to behave as a good leaving group in substitution reactions (Scheme 1). Thus, the development of