Beilstein J. Org. Chem.2018,14, 1293–1308, doi:10.3762/bjoc.14.111
presence of transfection agents, suggesting that the altered charge pattern of the oligonucleotide backbone enabled its cellular self-delivery [44]. The same authors then also studied similar oligonucleotides with guanidinium groups as cationic moieties, which were obtained by postsynthetic guanidinylation
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Graphical Abstract
Figure 1:
Biological action of single-stranded oligonucleotides (ON): antigene and antisense pathways.
Beilstein J. Org. Chem.2013,9, 908–917, doi:10.3762/bjoc.9.104
inherently easily biodegradable. To meet the prerequisites for self-delivery systems, besides biodegradability, the hydrogelators should preserve the pharmacological efficacy of the therapeutic building blocks, any side effects should be minimized and the biocompatibility maximized. Therefore, a convenient
are excellent candidates to promote aromatic–aromatic interaction in water to form hydrogels, this work contributes to the development of functional molecules that have dual or multiple roles and ultimately may lead to new molecular hydrogels of therapeutic agents for topical use.
Keywords: self
-delivery; hydrogel; multifunctional; nanofibers; NSAID; self-assembly; supramolecular; topical use; Introduction
This article reports the design, synthesis, and characterization of hydrogelators made of non-steroidal anti-inflammatory drugs (NSAID) and small peptides for the development of multifunctional
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Graphical Abstract
Scheme 1:
The structures of the NSAIDs and peptides explored as the building blocks of hydrogelators in this ...