Synthesis of densely functionalized enantiopure indolizidines by ring- closing metathesis (RCM) of hydroxylamines from carbohydrate- derived nitrones

• Marco Bonanni,
• Marco Marradi,
• Francesca Cardona,
• Stefano Cicchi and
• Andrea Goti

Beilstein J. Org. Chem. 2007, 3, No. 44, doi:10.1186/1860-5397-3-44

• methodology, several symmetrically α,α'-disubstituted hydroxylamines 1 were afforded. An alternative protocol for the synthesis of unsymmetrically α,α'-disubstituted hydroxylamines 3, resulting from the sequential addition of two different Grignard reagents, was also developed in a stepwise process, based on