Beilstein J. Org. Chem.2022,18, 25–36, doi:10.3762/bjoc.18.3
through a gram-scale synthesis, one-pot three-component reactions and further transformation experiments of the products.
Keywords: asymmetric catalysis; cyclization reaction; Michael addition; one-pot three-component reaction; spirobarbiturates; Introduction
Indane scaffolds exist in various
cascade reagent with the indane framework, namely, 2-isothiocyanato-1-indanone (Scheme 1a) [15], but research on its participation in the construction of chiral compounds has been relatively low [16][17].
On the other hand, as a kind of vital spiroheterocyclic derivatives, spirobarbiturates show a wide
or new methodologies to construct the spirobarbiturates with diverse structures. In recent years, good progress has been achieved in the construction of racemates of spirobarbiturates and the enantioselective synthesis [24][25][26][27][28][29], but only limited progress has been made in the
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Graphical Abstract
Figure 1:
Selected examples of natural products and drugs possessing the indane scaffold.