Streptoquinolines A and B, new antibacterial meroterpenoids produced by Streptomyces sp. TMPU-A0679

• Akiho Yagi,
• Hitomi Tomura,
• Ami Konno and
• Ryuji Uchida

Beilstein J. Org. Chem. 2026, 22, 185–191, doi:10.3762/bjoc.22.12

• -resistant Gram-positive pathogens. Keywords: meroterpenoid; quinoline; Streptomyces sp; streptoquinoline; VRE; Introduction The emergence of antimicrobial-resistant bacteria has become a serious public health issue worldwide. Infections caused by these pathogens severely limit available treatment options

• and 1620–1680 cm−1 indicated the presence of hydroxy and carbonyl groups, respectively. Streptoquinoline A (1): The molecular formula of 1 was elucidated as C28H35NO6 based on HRESIMS measurements. The 13C NMR spectrum (in DMSO-d6) showed 28 signals, which were classified into five methyl carbons

• . Streptoquinoline B (2): The molecular formula of compound 2 was elucidated as C28H35NO6 based on HRESIMS measurements. The 13C NMR and 1H NMR spectra (in DMSO-d6) of compound 2 showed chemical shift values that were almost identical to those of compound 1 (Table 2). Furthermore, 2D NMR experiments revealed similar