Beilstein J. Org. Chem.2013,9, 1730–1736, doi:10.3762/bjoc.9.199
, showed a notable antinociceptive and anti-inflammatory activity without toxic side-effects.
Keywords: antinociceptive/anti-inflammatory agents; imidazophosphor esters; phosphonyl carbanions; ring closure; tetrazolo[1,5-b]pyridazine; Introduction
Inflammation is a characteristic feature of disease
.
Conclusion
In summary, we have offered a practical and efficient procedure for the synthesis of imidazophosphor esters based tetrazolo[1,5-b]pyridazine in high yields by application of different types of Horner–Emmons (HE) reagents on 3,6-diazidopyridazine. Among the products, the β-enaminobisphosphonate
suitable for anti-inflammatory and antinociceptive agents, and by the fact that ring-fused heterocycles containing more than one nitrogen atom (e.g., tetrazole nuclei [21][22][23]) are key structures in a large variety of biochemical processes, bioscreening of the synthesized substituted tetrazolo[1,5-b
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Graphical Abstract
Scheme 1:
Synthesis of substituted diethyl oxophosphonate 4.