Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• group and by deprotection of the ketal with acetic acid. The resultant diol was reacted with thionyl chloride and the corresponding sulfite 222 was opened with sodium azide; oxidation to the more reactive sulfate was not necessary. The final sequence involved deprotection of the acetate followed by

Silica- bound benzoyl chloride mediated the solid- phase synthesis of 4H-3,1-benzoxazin- 4-ones

• Kurosh Rad-Moghadam and
• Somayeh Rouhi

Beilstein J. Org. Chem. 2009, 5, No. 13, doi:10.3762/bjoc.5.13

• synthesis of SBBC through which first the surface of silica gel was converted to silica chloride by means of reaction with thionyl chloride [27][28]. The silica chloride was heated with 4-hydroxybenzoic acid to form the silica-bound benzoic acid (SBBA). The SBBA was washed with acetone to remove excess 4

• -hydroxybenzoic acid. Finally, the silica-bound benzoyl chloride, SBBC, was obtained from the reaction of SBBA with thionyl chloride. The IR spectrum of SBBA revealed a band around 1660 cm−1 clearly indicative of C=O stretching vibration of the carboxyl groups while the absorbtion of C=O stretching vibration of

• dichloromethane and recovered by refluxing in thionyl chloride. Also, interesting to note is that under similar conditions and reaction times the treatment of 2-acylaminobenzoic acids with silica chloride 1 did not furnish the corresponding benzoxazinones. To investigate the recoverability of SBBC its reaction

Synthesis of crispine A analogues via an intramolecular Schmidt reaction

• Ajoy Kapat,
• Ponminor Senthil Kumar and
• Sundarababu Baskaran

Beilstein J. Org. Chem. 2007, 3, No. 49, doi:10.1186/1860-5397-3-49

• as a white crystalline solid. Diol 9 on bromination followed by nucleophilic displacement with NaCN furnished the desired dicyano compound 10. Treatment of dicyanide 10 with thionyl chloride in methanol gave the corresponding diester 11 as a colorless liquid in good yield. Compound 11 was then

Development of potential manufacturing routes for substituted thiophenes – Preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides

• John W. Hull Jr.,
• Duane R. Romer,
• David E. Podhorez,
• Mezzie L. Ash and
• Christine H. Brady

Beilstein J. Org. Chem. 2007, 3, No. 23, doi:10.1186/1860-5397-3-23

• ). Route selection studies carried out for approaches to 1 are summarized in Scheme 2. The key target was the bromo thiophene-2-carboxylic acid intermediate 19, which could be readily and cleanly converted to 1 by treatment with thionyl chloride. Scheme 2 shows three potential routes to 19 which were

• with CO2, 3,4,5-trichloro-2-thiophenecarboxylic acid 23 was isolated and dried prior to its conversion to 2 with thionyl chloride. Thus, 2 can be prepared in two chemical steps from the inexpensive chlorinated thiophene 22 using either lithiation or Grignard chemistry. [28] A comparison of some key

Synthesis and glycosidase inhibitory activity of new hexa- substituted C8-glycomimetics

• Olivia Andriuzzi,
• Christine Gravier-Pelletier,
• Gildas Bertho,
• Thierry Prangé and
• Yves Le Merrer

Beilstein J. Org. Chem. 2005, 1, No. 12, doi:10.1186/1860-5397-1-12

• acid catalyst such as ytterbium triflate, revealed unsuccessful, only leading to recover the starting material. To overcome this difficulty, we turned to a more electrophilic sulfate moiety [36] (Scheme 3). Thus, treatment of the cis-diols 3 and 4 with thionyl chloride in the presence of triethylamine