Beilstein J. Org. Chem.2009,5, No. 37, doi:10.3762/bjoc.5.37
bacterium Streptomyces cattleya as part of its defense strategy since 4-fluorothreonine (2) has antibiotic activity and fluoroacetate (1) is a toxin [1]. The biosynthetic pathway from fluoride ion to these fluorometabolites has largely been elucidated and is summarised in Scheme 1 [2].
The first committed
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Graphical Abstract
Scheme 1:
Biosynthetic pathway from fluoride ion to fluoroacetate 1 and 4-fluorothreonine 2 in S. cattleya [2].