Beilstein J. Org. Chem.2020,16, 1305–1312, doi:10.3762/bjoc.16.111
, Road, North Chicago, Illinois 60064, United States of America 10.3762/bjoc.16.111 Abstract The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the
catalysis; trifluoromethoxylation; Introduction
The number of fluorine-containing compounds and their influence in medicine and agrochemistry are increasing every year [1][2]. The introduction in a drug (or a bioactive compound in general) of single fluorine atoms, or multiple fluorine-containing
photoredox protocols for the radical trifluoromethoxylation of unfunctionalized (hetero)arenes by using specifically designed CF3O radical-releasing agents (Scheme 1B).
Following our long-standing interest in the development of continuous-flow approaches for C–H functionalization [18][26] and photochemical
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Graphical Abstract
Scheme 1:
A) Properties and B) synthesis of CF3O-bearing arenes; C) trifluoromethoxylation using the “second”...