A review of the total syntheses of triptolide

• Xiang Zhang,
• Zaozao Xiao and
• Hongtao Xu

Beilstein J. Org. Chem. 2019, 15, 1984–1995, doi:10.3762/bjoc.15.194

• Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, 201210, China 10.3762/bjoc.15.194 Abstract Triptolide is a complex triepoxide diterpene natural product that has attracted considerable interest in the organic chemistry and medicinal chemistry societies due to its intriguing structural features

• and multiple promising biological activities. In this review, progress in the total syntheses of triptolide are systematically summarized. We hope to gain a better understanding of the field and provide constructive suggestions for future studies of triptolide. Keywords: total synthesis; Tripterygium

• wilfordii Hook F; triptolide; Introduction Triptolide (1, Figure 1) is the first diterpenoid triepoxide isolated from Tripterygium wilfordii Hook F. (TWHF) in 1972 [1]. It has attracted an ever-increasing attention due to its intriguing structural features and various promising pharmacological activities