Beilstein J. Org. Chem.2010,6, No. 65, doi:10.3762/bjoc.6.65
stability compared to the intermediates with Rf groups with more than one carbon atom. In 2006 Togni and co-workers reported a new family of hypervalent iodine compounds in which the CF3 group is bonded directly to the iodine atom. The overall synthetic protocol depends on a formal umpolung of the CF3 group
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Graphical Abstract
Scheme 1:
Preparation of the first electrophilic trifluoromethylating reagent and its reaction with a thiophe...