Synthesis of novel (1-alkanoyloxy- 4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives

• Petri A. Turhanen and
• Jouko J. Vepsäläinen

Beilstein J. Org. Chem. 2006, 2, No. 2, doi:10.1186/1860-5397-2-2

• , the in situ prepared disodium salt of HABBPA was a good starting material because of its good solubility in water [solubility of HABBPA, its mono- and disodium salts in water (5 ml) were 41.4 mg, 161.7 mg and > 1000 mg, respectively, which were tested in room temperature] and reactivity of amino group