Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

• Annika Stein,
• Dave Compera,
• Bianka Karge,
• Mark Brönstrup and
• Jakob Franke

Beilstein J. Org. Chem. 2019, 15, 2003–2012, doi:10.3762/bjoc.15.196

• Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity. Here, we report two newly characterised withanolides, named

• lower than those of 4ß-hydroxywithanolide E. Our work establishes androwithanolides as a new subclass of withanolides. Keywords: androstanes; Physalis peruviana; steroids; structure elucidation; withanolides; Introduction Traditional medicine has long been a source of inspiration for modern drug

• research. An important example is Withania somnifera, also known as ashwaghanda or Indian ginseng, which has been used in Ayurvedic medicine to treat a large variety of ailments [1]. Extensive studies revealed withanolides, a class of steroidal lactones, to be primarily responsible for the medicinal