Beilstein J. Org. Chem.2022,18, 53–69, doi:10.3762/bjoc.18.5
against various microorganisms and pharmacological targets, including being used in the preparation of several drugs that are on the pharmaceutical market. Among these naphthoquinones, the series of compounds prepared from 1,2-naphthoquinone-4-sulfonic acid salts (β-NQS) stands out. In addition to being
used in organic synthesis, they are excellent analytical derivatization reagents to spectrophotometrically determine drugs containing primary and secondary amino groups. This review summarizes the literature involving β-NQS.
Keywords: biological activities; derivatization reagents; β-NQS; organic
. Others are exclusively synthetic (6–8) and prepared from naphthoquinones 1 or 2. Except for naphthoquinone 8 (β-NQS), the applications in organic synthesis of all other in Figure 1 shown naphthoquinones are already summarized in reviews [13][14][15][16][17][18][19][20].
Several natural naphthoquinones
PDF
Graphical Abstract
Figure 1:
Naphthoquinones are commonly used in organic synthesis.