Enzymes in chemical transformations
Prof. Karen N. Allen, Boston University
Christian P. Whitman, The University of Texas at Austin
Donald Hilvert, ETH Zürich
Enzyme research embraces many disciplines and connects scientists from different fields. This thematic issue will highlight enzyme-mediated chemical transformations, their elucidation, and their purposing for roles outside their normal biological contexts. It will encompass enzyme kinetics, enzyme inhibitors and inhibitor discovery, enzyme engineering, design and validation of enzymatic reactions, enzymes in organic reactions, and enzymes in industry. These areas naturally include experimental enzyme function assignment and determination of enzyme mechanisms.
The enzymes of microbial nicotine metabolism
- Paul F. Fitzpatrick
Beilstein J. Org. Chem. 2018, 14, 2295–2307, doi:10.3762/bjoc.14.204
Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis
- Ilja V. Fateev,
- Ekaterina V. Sinitsina,
- Aiguzel U. Bikanasova,
- Maria A. Kostromina,
- Elena S. Tuzova,
- Larisa V. Esipova,
- Tatiana I. Muravyova,
- Alexei L. Kayushin,
- Irina D. Konstantinova and
- Roman S. Esipov
Beilstein J. Org. Chem. 2018, 14, 3098–3105, doi:10.3762/bjoc.14.289
New standards for collecting and fitting steady state kinetic data
- Kenneth A. Johnson
Beilstein J. Org. Chem. 2019, 15, 16–29, doi:10.3762/bjoc.15.2
Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis
- Ferran Planas,
- Michael J. McLeish and
- Fahmi Himo
Beilstein J. Org. Chem. 2019, 15, 145–159, doi:10.3762/bjoc.15.15
Back to the future: Why we need enzymology to build a synthetic metabolism of the future
- Tobias J. Erb
Beilstein J. Org. Chem. 2019, 15, 551–557, doi:10.3762/bjoc.15.49
