Medicinal chemistry and drug discovery in an opening era

Editor: Prof. Matthew Todd
University College London

Organic Chemistry drives the discovery of molecules that have the potential to transform global health. New synthetic and analytical methods promise significant improvements in the speed of this discovery and the quality of any resulting pharmaceuticals. In parallel it is now understood that i) improved sharing of data and ideas can radically improve our ability to discover and develop medicines and ii) the scientific community will greatly benefit if its work can be machine-readable, so as to harness creative ideas from new methods in artificial intelligence and machine learning.

This special issue focuses on breakthrough new scientific methods in medicinal chemistry and drug discovery, with a theme of how the sharing of open data can increase the impact of the research.

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An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

  • Nicky J. Willis,
  • Elliott D. Bayle,
  • George Papageorgiou,
  • David Steadman,
  • Benjamin N. Atkinson,
  • William Mahy and
  • Paul V. Fish

Beilstein J. Org. Chem. 2019, 15, 2790–2797, doi:10.3762/bjoc.15.271

Graphical Abstract
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Full Research Paper
Published 19 Nov 2019

Opening up connectivity between documents, structures and bioactivity

  • Christopher Southan

Beilstein J. Org. Chem. 2020, 16, 596–606, doi:10.3762/bjoc.16.54

Graphical Abstract
Supp Info
Published 02 Apr 2020

Anthelmintic drug discovery: target identification, screening methods and the role of open science

  • Frederick A. Partridge,
  • Ruth Forman,
  • Carole J. R. Bataille,
  • Graham M. Wynne,
  • Marina Nick,
  • Angela J. Russell,
  • Kathryn J. Else and
  • David B. Sattelle

Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105

Graphical Abstract
Published 02 Jun 2020
Other Beilstein-Institut Open Science Activities