Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• nanomaterials remain either minimal or entirely absent. This regulatory fragmentation is a global issue that badly hinders the worldwide utilization of nanotechnology. The situation is further exacerbated by the rapid pace of nanotechnology advancement, mostly in critical sectors such as healthcare, energy

• technological platforms in energy, healthcare, computing, and advanced manufacturing. List of well-known global companies and startups driving nanomaterials, nanotechnology products, and devices. Though not exclusively focused on nanotechnology, these organizations remain key players transitioning from

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• years, the integration of science and technology has been well orchestrated to address challenges in medicine and health sciences and to evaluate therapeutic aspects [1]. This integration has contributed to the development of a more efficient healthcare system, innovative nanomedical tools and advanced

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• -friendly innovation, particularly in healthcare [30][31]. The economic feasibility and simplicity of green synthesis methods also align well with the resource-limited infrastructure often encountered in academic laboratories across developing nations. India’s high burden of oral and systemic infectious

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• of their production, these materials have to be stable and safe in the body, and they must comply with regulatory requirements before healthcare sectors can rely on them. So far, the achievements in nanotechnology for diagnostics seem positive, and we can expect this area to keep improving as

• usage in everyday healthcare is becoming more evident. Liposomes and polymeric nanoparticles are already being used in certain cancer and vaccine treatments [41]. Detection of diseases at an early stage is becoming more possible with gold nanoparticles or quantum dots. Scaffolds made from nanofibers and

• medicine. They not only enhance what we already have, but also help to develop new types of treatments and diagnostics with more effectiveness. Ongoing research, responsive development, and collaboration might enable nanotechnology to transform modern healthcare on an unprecedented scale [42]. Iqra Zainab

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• ]. There are several reports about the severe adverse reactions in patients taking these drugs [14][15]. In addition, the economic impact of these degenerative and inflammatory diseases, such as rheumatoid arthritis, is significant, as demonstrated by heightened healthcare resource utilization and

Synthesis and magnetic transitions of rare-earth-free Fe–Mn–Ni–Si-based compositionally complex alloys at bulk and nanoscale

• Shabbir Tahir,
• Tatiana Smoliarova,
• Carlos Doñate-Buendía,
• Michael Farle,
• Natalia Shkodich and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 823–836, doi:10.3762/bjnano.16.62

• fluctuations or trigger mechanical responses, making them essential in automation, industrial processes, and healthcare monitoring technologies. Considerable research has been dedicated to tailoring the Curie temperature and associated magnetic properties through material design. Advances in composition

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• by combining the unique properties of silk and PU, opening up the possibilities for innovative treatments. Keywords: electrospinning; nanofibers; polyurethane; silk fibroin; skin regeneration; wound healing; Introduction The biomedical field is a revolutionary sector in healthcare and research

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts

• Yunus Ahmed,
• Keya Rani Dutta,
• Parul Akhtar,
• Md. Arif Hossen,
• Md. Jahangir Alam,
• Obaid A. Alharbi,
• Hamad AlMohamadi and
• Abdul Wahab Mohammad

Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21

• aquaculture, domestic sewage discharges, pharmaceutical manufacturing, and healthcare facilities [38]. Antibiotics are commonly administered to animals through feed or water, primarily for growth promotion in large-scale animal farming operations and to prevent and treat infectious diseases [39]. Consequently

• , and dispose of significant quantities of antibiotics during production. A study found that downstream water sources from pharmaceutical production plants had significantly higher antibiotic concentrations than upstream sources [44]. Hospitals and healthcare facilities also significantly contribute

• antibiotics. Multiple sources Antibiotics can enter the environment through various pathways, including wastewater discharges from healthcare facilities, pharmaceutical industry effluents, agricultural runoff, and human and animal waste [48]. However, effectively locating and regulating each source poses a

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• , patient-centered research regarding various ophthalmic conditions is crucial to ensure the widespread future use of photothermal nanomaterials. Economic, social, and cultural initiatives to enhance awareness about photothermal nanomaterials and their impact on healthcare policy, especially for

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• hepatocellular carcinoma (HCC), are major global health concerns, affecting millions worldwide and placing a significant burden on healthcare systems. Viral hepatitis, for example, affects over 300 million people globally and remains a leading cause of liver-related morbidity and mortality [82]. Cirrhosis, a

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery

• Elina E. Mansurova,
• Andrey A. Maslennikov,
• Anna P. Lyubina,
• Alexandra D. Voloshina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Anzhela A. Mikhailova,
• Polina V. Mikshina,
• Albina Y. Ziganshina and
• Igor S. Antipin

Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2

• Cytell Cell Imaging multifunctional system (GE Healthcare Life Science, Sweden) [38]. The experiments utilized a Chang liver cell line (human liver cells) from the N.F. Gamaleya National Research Center for Epidemiology and Microbiology and a cell culture of WI-38 VA 13 subline 2RA (human embryo lung

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• estimated due to neurological diseases [5]. The estimated cost of these diseases to the European healthcare budget is around 800 billion Euros per year [6]. From a pharmaceutical point of view, although there is an immense network of cerebral vascularization, providing therapeutics for CNS diseases is

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• discuss the current challenges in the drug delivery field and sensing techniques and the significant role of alginate-based nanoparticles in overcoming these problems. Background Drug delivery and sensing in healthcare: significance and impact Drug delivery refers to the process of administering

• body, increasing the delivery efficiency of drugs [41]. In addition to drug delivery, sensing technologies are also of great importance in healthcare. Sensing technologies enable healthcare professionals to monitor patients’ health conditions, track the effectiveness of treatments, and detect any

Atomistic insights into the morphological dynamics of gold and platinum nanoparticles: MD simulations in vacuum and aqueous media

• Evangelos Voyiatzis,
• Eugenia Valsami-Jones and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 995–1009, doi:10.3762/bjnano.15.81

• , anthropogenic, and geological processes [3]. Only a few decades ago, NPs attracted attention because of their size-dependent chemical and physical properties [4]; nowadays, they are commercially available and exploited in several sectors such as optics, automotive, electronics, and healthcare [5][6]. A notable

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• , Siemens Healthcare, Erlangen, Germany). Drug release The release of CUR and Mn2+ from the CUR-Fe@MnO2 NFs was explored via dialysis. In brief, CUR-Fe@MnO2 NFs were released in PBS containing 0.7% (w/w) Tween 80 at different pH values (7.4 or 5.0) with or without GSH (20 μM/10 mM) and with or without H2O2

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• Antioxidants play an important role in the prevention of oxidative stress and have been widely used in medicine and healthcare. However, natural antioxidants have several limitations such as low stability, difficult long-term storage, and high cost of large-scale production. Along with significant advances in

• nanomaterials in medicine and healthcare are also discussed. This review provides a deeper understanding of the mechanisms of metal-based nanoantioxidants and a guideline for using these nanomaterials in medicine and healthcare. Keywords: antioxidant nanomaterial; healthcare; medicine; nanotechnology

• action, and expand their applications, especially in medicine and healthcare. For example, the question of why nanoparticles with a majority of Ce3+ on the surface have stronger antioxidant activity than those with Ce4+ has recently been answered by Dutta and co-workers [11]. Ce3+ nanoparticles have a

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• [5]. Globally, CD creates an annual burden exceeding 800,000 disability-adjusted life years and $600,000,000 in healthcare costs [6]. Classically, the infectious cycle in the human host begins as an acute phase, asymptomatic except in children, where trypomastigotes circulate in the blood and

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• drawback to TDD needles is trypanophobia, a fear of needles. Roughly 3.5–20.0% of the general population suffers from trypanophobia to various degrees [5][6]. Additionally, healthcare workers are continuously at risk for sharps-related injuries, and hollow-bore needles account for 56% of all sharps

• injuries [7]. An estimated two million hospital-based workers suffer from work-related needle injuries, adding burdensome financial cost and infection risks to healthcare systems [8][9]. With the advent of advanced additive manufacturing techniques, we can miniaturize needles (microneedles) to overcome

• medical device for administering drugs and collecting biological fluids, all while reducing sharps-related risks to healthcare professionals. To date, microneedle patches are relatively simple with a one-size-fits-all approach, regardless of patient demographic and injection site. 3D microfabrication

A wearable nanoscale heart sound sensor based on P(VDF-TrFE)/ZnO/GR and its application in cardiac disease detection

• Yi Luo,
• Jian Liu,
• Jiachang Zhang,
• Yu Xiao,
• Ying Wu and
• Zhidong Zhao

Beilstein J. Nanotechnol. 2023, 14, 819–833, doi:10.3762/bjnano.14.67

• advancement in wearable electronic devices within the healthcare field, leading to several noteworthy breakthroughs. For instance, D. Wan et al. [11] presented a groundbreaking development in the form of a flexible wearable friction patch. This innovative patch consists of a dual-layer PDMS membrane infused

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

Carbon nanotube-cellulose ink for rapid solvent identification

• Tiago Amarante,
• Thiago H. R. Cunha,
• Claudio Laudares,
• Ana P. M. Barboza,
• Ana Carolina dos Santos,
• Cíntia L. Pereira,
• Vinicius Ornelas,
• Bernardo R. A. Neves,
• André S. Ferlauto and
• Rodrigo G. Lacerda

Beilstein J. Nanotechnol. 2023, 14, 535–543, doi:10.3762/bjnano.14.44

• and flexible devices are paradigms of the current “Industry 4.0”. One can envision applications such as multicomponent liquid and gas sensors, wearables for healthcare, paper-based sensors, and electronic solutions for smart city applications [1][2][3][4][5]. Another area of increasing demand is the

A mid-infrared focusing grating coupler with a single circular arc element based on germanium on silicon

• Xiaojun Zhu,
• Shuai Li,
• Ang Sun,
• Yongquan Pan,
• Wen Liu,
• Yue Wu,
• Guoan Zhang and
• Yuechun Shi

Beilstein J. Nanotechnol. 2023, 14, 478–484, doi:10.3762/bjnano.14.38

• proposed MIR grating coupler [14]. Finally, the transmission characteristics of the output fiber can be detected using an optical spectrum analyzer. There is a wide range of sensors for applications in, for example, biosensing, healthcare, disease detection, and gas detection. Therefore, research on those

• , transparent, and portable wrist strap sensor and a mechano-based transductive sensor in 2017 and 2018, respectively [16][17]. They have good application prospects in healthcare. In 2020, Xue et al. reported a bismuthene-enabled fluorescence quenching biosensor to detect microRNA, which is relevant to the

Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

• Akif Hakan Kurt,
• Elif Berna Olutas,
• Fatma Avcioglu,
• Hamza Karakuş,
• Mehmet Ali Sungur,
• Cansu Kara Oztabag and
• Muhammet Yıldırım

Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31

• Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) and the Gram-negative Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) bacteria cause various infections [5]. These infections, formerly known as nosocomial infections, are now referred to as healthcare

• range of uses such as antibacterial and antimicrobial agents, healthcare-related products, medical device coatings, anticancer agents, optical sensors, anti-inflammatory agents, biocatalysts, cosmetics, and biosensors [41][42][43][44][45]. The combination of polymer-coated metal nanoparticles

Frequency-dependent nanomechanical profiling for medical diagnosis

• Santiago D. Solares and
• Alexander X. Cartagena-Rivera

Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122

• became evident, although its incorporation into healthcare applications remains relatively limited. Here, we briefly explore the reasons for this low level of technological adoption. We also propose a path forward for the incorporation of frequency-dependent nanomechanical measurements into integrated

• healthcare strategies that link routine AFM measurements with computer analysis, real-time communication with healthcare providers, and medical databases. This approach would be appropriate for diseases such as cancer, lupus, arteriosclerosis and arthritis, among others, which bring about significant

• mechanical changes in the affected tissues. Keywords: atomic force microscopy; healthcare; mechanical properties; mechanobiology; medical diagnosis; Introduction Since its invention in the early 1980s, atomic force microscopy (AFM) has been extensively used for topographical, mechanical, electrical, and

A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures

• Irena Mihailova,
• Vjaceslavs Gerbreders,
• Marina Krasovska,
• Eriks Sledevskis,
• Valdis Mizers,
• Andrejs Bulanovs and
• Andrejs Ogurcovs

Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35

• healthcare to analyse changes in the concentration of H2O2 in biological fluids. Also, a promising option to study more complex analytes and to significantly increase the sensitivity is the use of this nanostructured CuO sensor as part of a multisensor system based on several types of metal oxides (e.g