Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• -altitude lakes, where particles accumulate in the gut and gill tissues and interfere with normal physiological functions [113]. The low molecular weight of MPs, and particularly nanoparticles (NPs), allows them to easily translocate into organs and tissues resulting in inflammation, oxidative stress, and

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• risk; cardiotoxicity, which may result in heart failure or complications, especially with higher cumulative doses or existing heart conditions; severe nausea and vomiting if not managed with antiemetics; hair loss, which can be temporary or permanent; mucositis, involving inflammation of the mouth

• , aspect ratio, surface area, and surface chemistry result in unique biodistribution patterns, metabolic fates, and pharmacokinetic profiles. For instance, the high aspect ratio of carbon nanotubes (CNTs) contributes to their prolonged pulmonary retention, often linked to chronic inflammation and fibrotic

• the purity of the NMs and remove any impurities before their use, such as CCFs [43]. Studies have shown that CCFs can induce oxidative stress and inflammation in cells, potentially leading to cellular damage and toxicity [44]. The potential toxicity of CCFs is a concern in the field of CNM research

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• periodontopathogens such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, reducing inflammation and supporting adjunctive treatment to scaling and root planing. Regenerative strategies are also being developed, in which nanoparticle-functionalized membranes have shown potential to modulate host

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• nanomaterials. Numerous adverse health effects, such as inflammation, gastrointestinal disorders, cellular toxicity, and genetic damage, are linked to nanomaterial accumulation, as shown in many studies [115]. Furthermore, the application of biosolids containing nanomaterials to agricultural soils can lead to

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• , demonstrating nontoxicity and a reduction in joint inflammation, which were attributed to the physicochemical stability of the NPs in the gastrointestinal tract. Continuing their research on lactoferrin, Mahidhara et al. [112] developed chitosan-coated nanocapsules wrapped in alginate that achieved a 4.8-fold

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• cell cycle arrest, regulate oxidative stress, enhance metabolic reprogramming, inhibit invasion and metastasis, and modulate immunity and inflammation [129]. The developed nanoparticles underwent physicochemical characterization by SEM, UV–vis spectroscopy, and encapsulation testing, in which the

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• interact with upregulated mannose receptors on macrophage surfaces during inflammation. Mannosylated polymeric ligands have been developed for targeted delivery of antibacterial drugs to macrophages, leveraging the high-affinity interaction with mannose receptors on these immune cells [52]. Additionally

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• , Federal University of Mato Grosso do Sul, Av. Costa e Silva s/n, 79070-900, Campo Grande-MS, Brazil Laboratory of Pharmaceutical Technology, Federal University of Mato Grosso do Sul, Av. Costa e Silva, s/n, 79070-900, Campo Grande-MS, Brazil Laboratory of Pharmacology and Inflammation, Federal University

• : Acrocomia aculeata; cytotoxicity; hemolysis; inflammation; nanoemulsion; Introduction Acrocomia aculeata Jacq is a palm of the Arecaceae family, commonly known as bocaiúva or macaúba. It is widespread in South America and is particularly abundant in Mato Grosso do Sul, located in the Center-West region of

• traditional populations for managing joint inflammation and some infections [51]. Nevertheless, further comprehensive studies are necessary to confirm the long-term safety and therapeutic viability of the bocaiúva oil loaded nanoemulsions. Anti-inflammatory activity of Acrocomia aculeata oil-based

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• among the white blood cells [35]. Neutrophils are the first to appear at the site of inflammation and easily cross different biological barriers such as blood–tissue barrier, blood–brain barrier (BBB) or blood–tumor barrier (BTB). Therefore, neutrophil membrane-coated nanoparticles have been

Electronic and optical properties of chloropicrin adsorbed ZnS nanotubes: first principle analysis

• Prakash Yadav,
• Boddepalli SanthiBhushan and
• Anurag Srivastava

Beilstein J. Nanotechnol. 2025, 16, 1184–1196, doi:10.3762/bjnano.16.87

• hours of exposure, with studies reporting that 99% of individuals exposed to CP experience ocular symptoms, including inflammation, corneal edema, tissue damage, and potential visual impairment [6][7][8]. Developing portable, sensitive, rapid-response, and reliable sensors for detecting chemical warfare

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• . Additionally, the ME was able to provide additional benefits, such as reduced liver damage, improved renal function, reduced systemic inflammation, and increased high-density lipoprotein levels. Overall, the results show that EOCF was efficiently incorporated into the microemulsion, improving its antioxidant

• reduce ALT and AST liver dysfunction and showed no significant difference when compared to the negative control. Considering the ALT/AST ratio in all groups, the values remained below 1.5 at the end of treatment, with no significant differences (Figure 6C). Considering the inflammation marker C-reactive

• suggest attenuation of hepatic injury and systemic inflammation, which are commonly exacerbated in diabetic states. These effects may be attributed to the modulation of oxidative stress pathways, particularly through the scavenging of free radicals and the upregulation of endogenous antioxidant enzymes

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• skin tissue [31]. After skin injury, a series of processes known as the “wound healing process” occurs to regain the skin’s structural and functional properties. As shown in Figure 1, the wound healing process consists of four stages, namely, hemostasis, inflammation, new tissue generation, and

• resident skin cells [36]. Inflammation At this stage of wound healing, skin regeneration begins and continues till the end. Skin regeneration is essential for maintaining homeostasis, avoiding infection, and repairing the skin’s barrier function [37]. The inflammation process kills pathogens, prevents the

• , and cytokines regulate the leucocytes at the injury site. Neutrophils (leucocytes) remove pathogens and necrotic tissues by phagocytosis, antimicrobial peptides, and the release of active oxygen species, proteolytic enzymes, as well as eicosanoids [39]. Excessive and uncontrolled inflammation causes

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• local inflammation, and impair autophagy processes, which collectively contribute to neuronal loss. As such, targeting AβOs specifically, rather than solely focusing on amyloid-β fibrils (AβFs), may offer a more effective therapeutic approach for AD. Recent advances in detection and diagnosis have

• amyloid oligomers have led to side effects such as hydrocephalus, inflammation, and amyloid-related imaging abnormalities [90]. These side effects can be attributed to the activation of the complement system by the interaction of amyloid oligomers and antibodies, leading to the release of proinflammatory

• result in extended exposure, leading to their accumulation in various tissues and organs, such as liver, kidneys, brain, and lungs. This accumulation can cause both local and systemic toxicity. Additionally, NPs have the potential to trigger immune responses, including inflammation and allergic reactions

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• nm were more toxic than smaller ones for RAW264.7 macrophage cells [83]. It was also shown that long MWCNTs (20 µm) were cytotoxic to macrophages unlike short ones (0.6 µm) [84], that longer ones (825 nm) induced more intensive inflammation than shorter ones (220 nm) [85], and that longer CNTs had

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• addition, the cornea, an ocular tissue, is relatively “immune amnestied” because of the absence of blood vessels and lymphatic vessels, which reduces the patient’s immune response and inflammation and improves the safety and efficacy of photothermal nanomaterials therapy [12][13]. The small size of

• AuAgCu2O-NS, using it to combat local bacterial infections and severe inflammation in a rabbit model of endophthalmitis [153]. Moreover, a gel comprising AgCu2O and ethylene diamine tetraacetic acid (EDTA) has been formulated, demonstrating therapeutic efficacy in treating fungal keratitis [154]. In in

• corneal neovascularization and a thicker cornea due to inflammation and edema. A bimodal PAI system consisting of exogenous contrast agents (AuPt-ICG [204], R-s-ICG [205]) combined with endogenous contrast agents (hemoglobin [206]) helps to enhance photoacoustic imaging. The system allows for real-time

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• be considered a therapeutic target, exploiting their natural ability to phagocyte external agents such as NCs. Both monocytes and macrophages perpetuate tissue damage during chronic inflammatory disorders. They are implicated in preventing and resolving inflammation and wound-healing response [8

• tissue repair and homeostasis, regulating inflammation and its resolution by adopting different functional states, simplified in classically activated (M1) and alternatively activated (M2). This activation occurs on a spectrum, with various intermediate states influenced by microenvironmental signals

• : essential mechanisms in disease and healing The role of macrophages in disease pathogenesis is closely tied to their activation states. M1 macrophages – drivers of inflammation: M1 macrophages are induced by pro-inflammatory stimuli like lipopolysaccharide (LPS) and interferon gamma (IFN-γ), which trigger a

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• nanoparticles loaded with the immunosuppressant FK506 have demonstrated increased delivery to inflammation sites and reduced symptoms such as redness and inflammation in the hind limbs of mice [27][74]. In the treatment of COVID-19, biomimetic nanocarriers have also been used to optimize anti-inflammatory and

• bioavailability and drug delivery. Additionally, the capacity of these nanocarriers to react with reactive oxygen species at inflammation sites offers an anti-inflammatory response, reducing tissue damage [76][77]. Within this scope, manganese dioxide nanocarriers have been studied to address a challenge in

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• -PLHNPs than that of the free drug. Jøraholmen and co-workers fabricated polymer-coated liposomes using CHS for better topical delivery of RVT to treat vaginal inflammation and infections [109]. The developed RVT-PLHNPs showed excellent mucoadhesive characteristics and sustained drug release. The radical

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• reducing the thrombogenicity of a material lies in addressing the intricate layer of protein within blood that adsorbs to any surface it comes into contact with. This layer is responsible for the initiation of host responses such as coagulation or inflammation. To address the body’s reaction to these

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• of their unique properties. However, their size, surface area, and reactivity can cause toxicity, potentially leading to oxidative stress, inflammation, and cellular or DNA damage. In this study, a nano-quantitative structure–toxicity relationship (nano-QSTR) model was initially developed to assess

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• parenchymal tissue injury and attenuating parenchymal stress and inflammation. In this approach, anti-inflammatory substances are used, such as corticosteroids, colchicine, and ursodeoxycholic acid [14][15]. As the activation of HSCs is a hallmark of liver fibrosis, targeting signaling molecules involved in

• model, the efficient intrahepatic delivery of R406-PLGA NPs ameliorated liver inflammation, fibrosis, and hepatic steatosis, probably because of improved pharmacokinetics and bioavailability of R406. Despite its favorable toxicity profile, only 19 drug formulations based on PLGA have been approved by

• antioxidant, antibacterial, and anti-inflammation properties [63]. The combined administration of SeNPs and vitamin E resulted in an in vivo reduction of hepatic enzyme activity induced by acrylamide while also improving the lipid profile and histological hepatic tissues. In addition, zinc oxide NPs displayed

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• homeostatic dressing agent for wound healing. In addition, it can be utilized as an emulsifier and thickener in cosmetics, dentistry, and tissue engineering [29]. Furthermore, alginate decreases stomach inflammation and helps the healing of the gastric mucosa. Consequently, it can both protect the stomach and