Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• scales of the liquid evaporation and the particle movement: The solvent evaporates so slowly that particles move over at least mesoscale distances, thus allowing for aggregation in the ring [33]. In our research, the deposition protocol may have influenced the observed phenomena. The hydrophilic APDMES

• favors NP–surface interactions with subsequent immobilization. This can be based on multiple hydrogen bonds between the NH3+ groups in APDMES and the OH groups in the dimannoside, which immobilize the NPs long before solvent evaporation. Consequently, in this case, we observed no “coffee ring” effect

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• Discussion Oil extraction and characterization OPS was extracted using the Soxhlet method with n-hexane as the solvent, yielding 30.5 ± 0.8% (w/w) relative to the initial seed mass. After extraction, the oil was dried using a rotary evaporator to remove residual solvent, filtered through a PTFE membrane

• ether to ≈34% with hexane [3][4][5]. Such variations are commonly influenced by parameters including solvent type, moisture content of the seeds, extraction time, and temperature conditions [6]. The chemical profile of OPS was determined after transesterification to fatty acid methyl esters (FAME

• healing [17][18][19]. In addition to its chemical characterization, the thermal stability in inert atmosphere (N2) of OPS was assessed. Thermogravimetric analysis (TGA) revealed an initial mass loss of less than 1% (Tonset = 60 °C), likely associated with the evaporation of residual solvent entrapped in

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• available material confirmed the method’s reliability. The data underline how crucial the choice of the right solvent is if one wants to reach sufficient selectivity. Together with a series of custom-made organosilica aerogels, it is shown that adjusting solvent and surface properties so that the two

• ) as a spin probe, we observed that the ESR spectra consist of two species, one rotating freely and the other one much more slowly with tumbling dynamics [42]. Because these two species can be correlated to 3CP in the solvent (fast rotation) and 3CP adsorbed at the surfaces (slow dynamics

• ), quantitative evaluation of the spectra allowed for investigating various confinement effects. Our focus was on understanding how a particular functionalization of the surfaces in combination with 3CP and the solvent influences transport properties, and novel ESR imaging techniques were used to determine

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• concentration, surface tension, conductivity, and solvent volatility, alongside careful consideration of electrospinning conditions, such as temperature and humidity [18][19]. The polymer selection of nanofibers intended for biomedical applications must prioritize not only mechanical strength, controlled

• number of beads and the formation of fibers with a more dispersed structure, likely reflecting insufficient polymer chain entanglement and Taylor cone instability. This behavior appears to result from interactions between NE-βCp droplets and HA chains, which may disrupt the jet and hinder solvent

• evaporation within the core, as also reported by Ricaurte et al. (2022) [46]. Air relative humidity was additionally found to influence solvent evaporation and the formation of uniform HA fibers. Similar to the observations reported by Yao et al. (2013), a stable process without interruptions was only

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• provided in [85][86], giving an insight on the dependences of the resulting morphology on the laser intensity and solvent used. The number of laser pulses determined the length and diameter of nanowires. For testing of the impact of the surrounding liquid, the process was held in ethanol, methanol, and

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• fully confirm the long-term stability and therapeutic reliability of the formulation. Additionally, the presence of glycerin as a co-solvent may have contributed to the reduction in interfacial tension and improved droplet uniformity, factors known to enhance long-term stability [41]. Importantly, the

• -solvent, Tween® 80, and ʟ-α-phosphatidylcholine (PC), as surfactants. For nanoemulsions containing phytol, 10 mg/g of the drug was added to OP. Subsequent to the nanoemulsification step, the nanoemulsions were transferred into hermetically sealed glass vials and stored at room temperature for further

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• , can occur in organic or aqueous continuous phases, with the latter offering a reduction of toxic solvent residues. Miniemulsion and microemulsion methods provide better control over particle size and distribution, although microemulsion polymerization often requires higher concentrations of

• commonly used methods for the preparation of PNs employing preformed polymers. These methods typically begin with the formulation of an emulsifying system, a step common to all techniques, followed by the formation of NPs through a process that varies depending on the method, such as solvent precipitation

• ][42]. These strategies involve dissolving or dispersing pre-existing polymers in appropriate solvents, followed by NP formation through approaches such as nanoprecipitation, solvent diffusion-emulsification, solvent evaporation, ionic gelation, and dialysis. Each technique is intrinsically linked to

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• the titration of the LO sample (mL), VB is the volume of KOH solution required for blank solvent titration (mL), [KOH] is the concentration of ethanolic KOH solution (0.093 mol·L−1), MA is the mass of the LO sample used (g), and 56.1 g·mol−1 is the molecular weight of KOH. Thermal analysis

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• selective solvent [110]. Ursolic acid exhibits anti-inflammatory, antimicrobial, antiviral, antioxidant, and antiproliferative properties, making it a potential antitumor agent [111]. It inhibits tumor cell proliferation, prevents metastasis and angiogenesis, and induces cell death [112]. The therapeutic

• nanoparticles can be synthesized using methods such as direct polymerization of monomers, nanoprecipitation, solvent evaporation emulsification, dispersion of preformed polymers, or salting-out [27]. For cancer and immunotherapy, polymeric nanoparticles offer advantages such as biocompatibility, stimulation of

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• -loaded PLA nanoparticles were fabricated by nanoprecipitation methods. In this technique, the PLA nanoparticles (NPs) were produced by low-energy solvent displacement and functionalized with polyethylenimine (cationic polymer) for the T. serrulatus protein adsorption. The NPs showed a mean diameter of

• functionalized cationic PLA nanoparticles adsorbed with negatively charged proteins was successfully developed by low-energy solvent diffusion method, producing effective and stable spherical cationic nanoparticles. The positive surface charge enabled a high protein incorporation into particles. The prolonged

• PVA (1.0% w/v), at an output flux of 3.0 mL⋅min−1. After titrations, the acetone organic solvent evaporation occurred under a 700 rpm of magnetic stirring overnight. After solvent evaporation, colloidal dispersions were centrifuged at 22,000g for 5 minutes. The T. serrulatus venom loading in the

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• -precipitation involves solvent displacement method, where acetone, ethanol, hexane are some of the solvents used [75]. In electrospinning, nanofibers are generated [76]. In parallel, green synthesis utilises biological entities such as plant extracts or microorganisms as reducing agents to produce eco-friendly

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• (CNTs) by growing dendrimers on their surface. First, CNTs were pre-functionalized with maleic acid (MA) via Diels–Alder reaction in presence of a deep eutectic solvent under ultrasonication. Subsequently, dendrimers of varying length were grown by the repeated reaction of ethylene diamine and MA. Raman

• involvement of harmful chemicals to pre-functionalize the CNTs with high loading but also provided an effective way to enhance the adsorption of heavy metal ions. Keywords: carbon nanotubes; deep eutectic solvent; dendrimers; Diels–Alder reaction; heavy metal ion adsorption; Introduction The contamination

• reagents or solvent systems [39][40]. DESs are formed through hydrogen bonding between two solid components resulting in eutectic liquids having a melting point lower than those of the individual components [41][42]. They offer advantages such as simple synthesis, low cost, and broad applications in

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• after LFL treatment. By adjusting processing parameters such as solvent choice, the defect emission, including green defect emissions, can be controlled, providing further opportunities for tailoring the optical properties of NPs for various applications. The mechanisms behind nanoparticle formation

• surrounding solvent, owing to the efficient light absorption capability of the NPs and their limited thermal transfer to the solvent. [35][63][72][73][74]. LIL also leads to phase transitions and morphological changes (Figure 7a–d) depending on the laser fluence and irradiation time [42]. Schematic

• illustrations of the pulsed laser heating mechanism are presented in Figure 7f,g. Factors such as laser fluence, irradiation time, and solvent properties, such as dielectric constant and thermal conductivity, must be carefully controlled to optimize nanoparticle formation [49][68][69][75]. Other factors like

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• . Bruker AV400 and VARIAN 300 NMR spectrometers were used to collect 13C NMR spectra at 298 K. CDCl3 solvent was used as internal standard in 13C NMR experiment (δ 77.00 ppm). A Scienta ESCA200 apparatus was used to record XPS spectra. The morphology of the membrane was monitored using a field-emission SEM

• water for solvent replacement, a process that lasted for 3 days. During the period, the water was changed once a day. Preparation of dopamine/hydrochloric acid buffer solution The buffer solution was prepared by modifying the reported method [35][36]. Typically, 0.121 g of Tris was dissolved in 100 mL

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• efficiency (EE). These techniques can be categorized into conventional approaches such as thin film hydration, reverse phase evaporation, solvent injection, detergent removal, and newer innovations. Also, modern techniques are further developments or adaptations of conventional approaches. These methods

• allow for better control of liposome size, lamellarity, and drug loading. For example, microfluidics, membrane contactors, and pressure-controlled processes can improve EE, reduce organic solvent residues, and improve scalability and reproducibility [111][112][113]. The most commonly used synthesis

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• nitrogen for 24 h to obtain the solvent-free oil. Physicochemical characterization of Acrocomia aculeata oil Relative density and refractive index of Acrocomia aculeata oil (AAO) were evaluated according to the American Pharmacopoeia [58]. Iodine value, peroxide value, acid value, and saponification index

• increased to 250 °C at a rate of 5 K/min, maintaining the final temperature for 10 min. Mass spectra were acquired using a mass range of m/z 40–500, an interface temperature of 250 °C, and an ion source temperature of 220 °C. The solvent cutoff time was 3 min, and the event time was 0.20 min. The sweep

• the absorbance of the solvent, and AC is the absorbance of the positive control [61][62]. Cytotoxic activity The cytotoxic activity of AANE was evaluated in murine macrophages of the J774 strain (ATCC USA) according to the technique described by Nakayama and colleagues [64]. Staurosporine (5 μg/mL

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• efficiently encapsulated 5-FU [196]. The 5-FU was encapsulated in the PLGA core using the solvent evaporation technique. Then, the nanoparticle was coated with cationic chitosan, aiming to promote ionic interactions with the anionic cell membrane of the tumor. Finally, eucalyptus oil (1%) was added to the

Investigation of the solubility of protoporphyrin IX in aqueous and hydroalcoholic solvent systems

• Michelly de Sá Matsuoka,
• Giovanna Carla Cadini Ruiz,
• Marcos Luciano Bruschi and
• Jéssica Bassi da Silva

Beilstein J. Nanotechnol. 2025, 16, 1209–1215, doi:10.3762/bjnano.16.89

• evaluate the solubility of PpIX in distinct solvent systems to support the development of novel pharmaceutical formulations. The shake-flask method was employed, using purified water, 50% ethanol (EtOH50), 77% ethanol (EtOH77), absolute ethanol (EtOHabs), and polymeric systems containing 10% (w/w

• ) poloxamer 407 (P407) in water, in EtOH50 or in EtOH77. Approximately 10 to 25 mg of PpIX was added to 25 mL of the solvent, and the solutions were stirred at 100 rpm, at 37 °C, for up to 96 h. The PpIX concentration was measured by using a validated method (R = 0.9973), with equilibrium reached within 30

• -assembling properties of P407 make it suitable for advanced nanostructures drug delivery platforms, including polymeric microneedles and hydrogels, ensuring enhanced drug retention and permeation [15][17][18]. Therefore, the present study aimed to investigate the best solvent system for PpIX, in order to

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• colloids (LSPC) [41][42][43][44] provides nanoparticles dispersed in liquids without the addition of common additives (e.g., citrate [45], tensides [46], polymers [47]) or support material to stabilize the particles with high variability on the used solvent, yielding colloidal nanoparticles with

• shown to be less expensive than wet chemically produced NPs after a break-even-point of 550 mg/h. Thus, it makes the laser system to be of low cost in large-scale processes [61]. Furthermore, procedures for LAL are usually not bound to strict limitations when it comes to pressure and solvent, as for

• . Furthermore, metalloid elements, such as phosphorous, silicon, boron, and carbon were shown to retard crystallization and favor the formation of long-range disordered structures. Organic solvent molecules used in LSPC can serve as a carbon source which strongly affects the stabilization of amorphous

Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy

• Taisei Himeda,
• Risako Kunitomi,
• Ryosuke Nabeya,
• Tamotsu Zako and
• Tsuyoshi Asahi

Beilstein J. Nanotechnol. 2025, 16, 1088–1096, doi:10.3762/bjnano.16.80

• nanoparticles and nanomicelle encapsulation have been used to disperse them in water [2][3][4][5][6][7]. For example, AlClPc has been loaded into nanoemulsions using castor oil and Cremophor ELP® [5]. ZnPc was dispersed in unilamellar liposomes by a solvent exchange method [7][8], and its photocytotoxicity

• suspended in a poor solvent is fragmented into nanoparticles by intense pulsed laser irradiation, and the sample suspension is directly converted in to a colloidal dispersion without any chemical additives in one step. It has been demonstrated that several hydrophobic dyes such as metal complex Pcs (MPcs

Single-layer graphene oxide film grown on α-Al₂O₃(0001) for use as an adsorbent

• Shiro Entani,
• Mitsunori Honda,
• Masaru Takizawa and
• Makoto Kohda

Beilstein J. Nanotechnol. 2025, 16, 1082–1087, doi:10.3762/bjnano.16.79

• drop-casting technique, wherein GO flakes dispersed in a solvent are cast onto a substrate [16][17]. This technique does not allow for the control of number of layers. Consequently, studies have been conducted to synthesize large-area and single-layer GO (SLGO) films. As mentioned above, GO films have

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• integrated with the solvent [279][280][281]. Furthermore, gel materials with excellent stimuli responsiveness and biocompatibility have also been widely developed. As the nanoarchitectonics of the polymers and molecular aggregates that constitute gels evolve, the design and functionality of gels are becoming

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• compound 1b, in which four terminal chloromethyl groups are tethered to the calixarene upper rim by amide bonds. The subsequent treatment with N,N-dimethylethanolamine in THF as a solvent, produced compound 1 bearing choline-like moieties. Compound 1 and its precursor 1b were characterized by 1D and 2D NMR

• , and the solvent was evaporated under reduced pressure at 35 °C. The resulting film was rehydrated with an aqueous solution of 1 (50 μM) by stirring overnight at room temperature. The final solution was left to equilibrate and filtered. Encapsulation efficiency (EE %) was calculated using the formula

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• absorption signal near the bleached region, signifying the broadening. The decay dynamics of these signals are dictated by electron–phonon coupling within the particle and phonon–solvent interaction at the particle surface, hence informing about the overall energy relaxation timescales. The application of

• within the particle. It was proposed that the solvent molecules directly interact with non-thermal electrons at the particle surface, particularly in very small particles. In fact, the relatively well-defined geometry of NP colloids that leads to excitation localization and uniformity as well as the

Heat-induced transformation of nickel-coated polycrystalline diamond film studied in situ by XPS and NEXAFS

• Olga V. Sedelnikova,
• Yuliya V. Fedoseeva,
• Dmitriy V. Gorodetskiy,
• Yuri N. Palyanov,
• Elena V. Shlyakhova,
• Eugene A. Maksimovskiy,
• Anna A. Makarova,
• Lyubov G. Bulusheva and
• Aleksandr V. Okotrub

Beilstein J. Nanotechnol. 2025, 16, 887–898, doi:10.3762/bjnano.16.67

• ]. The obtained films were about 500 μm thick. Synthetic SCD were produced using high-pressure high-temperature (HPHT) method on a BARS apparatus [54]. The starting materials included a graphite rod (99.99% purity), a Ni0.7Fe0.3 alloy as a solvent catalyst, and a synthetic diamond (≈0.5 mm) as a seed