Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• provided the recognition event, the chemiluminescent substrate (CDP-Star) acted as the indicator, and the sensing signal was the measured photon emission. In this competitive assay, VB12 antibodies were fixed onto a nitrocellulose membrane, then exposed to both VB12 and its enzyme-bound form for

Electromagnetic study of a split-ring resonator metamaterial with cold-electron bolometers

• Ekaterina A. Matrozova,
• Alexander V. Chiginev,
• Leonid S. Revin and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2025, 16, 2199–2206, doi:10.3762/bjnano.16.152

• solver of CST MWS in 3D mode. The simulated receiving structure is placed on a 500 μm thick silicon substrate. A 4 mm-diameter silicon hyperhemispherical lens is placed on the rear side of the substrate to efficiently couple the incident radiation into the planar structure. The external signal is

• parameters of the structure. Specifically, increasing the substrate thickness to 700 μm enables an increase in absorbed power up to 0.3 a.u. across an ultrabroad frequency range of 200–1200 GHz (Figure 5e). Such a thick substrate can be realized by using commercially available substrates with greater

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• dominant driver of particle motion, and strong particle–substrate interactions may lead to particle attachment before they are transported to the contact line, thereby preventing the formation of a “coffee ring” [34]. Detailed height measurements of adsorbed particles in water vapor AFM under variable RH

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• composed of polar bonds with N acting as electron donor and B acting as electron acceptor. Unlike graphene and graphite, h-BN shows high resistivity and is a large-bandgap semiconductor [17]. h-BN has a wide range of applications due to its unique properties [18]. It is used as a substrate material for

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• aliquot was drop-cast onto a clean SiO2/Si substrate and allowed to dry under ambient conditions. Imaging parameters All critical imaging parameters for the data presented in the figures are summarized in Table 2. The free oscillation amplitudes for the higher eigenmodes were selected independently under

• vibrations are shown in Figure 3g,h and Figure 3i,j, respectively. Both signals effectively differentiated MMT nanosheets from the substrate, with phase images exhibiting superior contrast. Histograms (Figure 3k–m), derived from selected regions in Figure 3c,h,j, further highlight the enhanced contrast in

• . Histograms in Figure 4k–n demonstrate that second eigenmode phase maps offered superior contrast compared to modulus, adhesion, and tapping mode images, enabling clear differentiation between the substrate, thinner and thicker regions of the nanosheets. Comparative imaging with a soft probe (ScanAsyst-air

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• dynamics to capture molecular interactions at the spatula–substrate interface and finite element method to simulate the mechanical behavior of the larger setal shaft. This hybrid approach enables synchronized simulations that resolve both fine-scale interfacial dynamics and overall structural deformation

• . The model reproduces key aspects of spatula behavior during adhesion and detachment, showing that spatula–substrate contact evolves through a combination of bending, sliding, and peeling, depending on the spatula’s initial orientation. Our results further demonstrate that lateral sliding can delay

• scales involved. In previous research, we used molecular dynamics simulations to explore various aspects of gecko adhesion [10][11][12][13]. We found that humidity increases the force required to pull a spatula off from a substrate [10][12], a phenomenon also observed in high-humidity atomic force

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• ng·µL−1 on dewaxed sections of S. alveolata and detected with anti digoxigenin-AP Fab fragments (Roche) at a dilution of 1:2000. The signal was developed using the NBT/BCIP substrate (Roche) at 37 °C. The sections were observed using a Zeiss Axio Scope A1 light microscope with a 100× objective to

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• way to the NPs discussed above [79]. This concept was introduced in the works of the A. Manshina group, who developed a remarkably different method of NP production at the target/liquid interface, where the continuous wave laser reduces the precursors at the substrate surface, resulting in the

Mechanical property measurements enabled by short-term Fourier-transform of atomic force microscopy thermal deflection analysis

• Thomas Mathias,
• Roland Bennewitz and
• Philip Egberts

Beilstein J. Nanotechnol. 2025, 16, 1952–1962, doi:10.3762/bjnano.16.136

• their polymerization/deposition. The topography of the surface was measured before acquiring a force-versus-distance measurement to ensure that these measurements were acquired on clean and flat regions of the substrate. To observe how the resonant frequency of the AFM cantilever changes as the attached

• tip is pressed against a substrate, force-versus-distance measurements were conducted. In these measurements, the sample was moved up and down at a rate of approximately 100 nm·s−1 while recording the cantilever deflection over the course of the measurement. In addition to the AFM’s own control

• with the high-sample rate acquisition system for a soft silicon cantilever on a HOPG substrate. Both the normal force and the cantilever displacement values are shown as most AFM studies report normal force values, but the power spectrum calculation requires the cantilever displacement values. Figure

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• duration of the electron or ion beam pulses. In FEBID and FIBID, volatile precursor molecules are delivered to the substrate surface via a gas injection system (GIS), where they adsorb and are subsequently decomposed by a focused electron or ion beam with energies in the kiloelectronvolt range. While

• masks, and resistance, with the flexibility of depositing materials on non-planar surfaces [4][5][14]. The FIBID method has several advantages compared to the FEBID technique in depositing thin films on substrates. First, ions generate more secondary electrons on the substrate surface than electrons

• significant beam-induced substrate defects (e.g., Ga atom implantation). Additionally, material growth is required to compete with the FIB milling process [4][9]. The use of ions instead of electrons, like in FEBID, offers several benefits, including enhanced film quality and adhesion, better control over the

Quantum circuits with SINIS structures

• Mikhail Tarasov,
• Mikhail Fominskii,
• Aleksandra Gunbina,
• Artem Krasilnikov,
• Maria Mansfeld,
• Dmitrii Kukushkin,
• Andrei Maruhno,
• Valeria Ievleva,
• Mikhail Strelkov,
• Daniil Zhogov,
• Konstantin Arutyunov,
• Vyacheslav Vdovin,
• Vladislav Stolyarov and
• Valerian Edelman

Beilstein J. Nanotechnol. 2025, 16, 1931–1941, doi:10.3762/bjnano.16.134

• with selective etching of superconducting and normal metal electrodes. Improvement in ultimate sensitivity is achieved by suspending the absorber above the substrate. Best responsivity of up to 30 electrons per photon at a frequency of 350 GHz, or 72000 A/W, and voltage responsivity up to 3.9 × 109 V/W

• not very high reproducibility and stability. Another fabrication method is the Manhattan technology [28] with deep orthogonal groves in the resist, see Figure 1b,c. Both methods are based on thermal evaporation at different angles and rotation of substrate, requiring rather sophisticated and expensive

• is used before making of the insulator and sputtering of the normal metal (for details see [29]). An example of such a method is presented in Figure 1d,e. Besides SINIS structures with N-absorber on the substrate, we also developed devices with the absorber suspended above the substrate (Figure 1f

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• Si–N plate released from a Si substrate. The microwave superconducting lumped-element resonant circuit consists of an interdigital capacitor in series with a meandering nanowire inductor, both fabricated from a single layer of Nb–Ti–N deposited on the Si–N. The nanowire meanders across the clamping

• on a silicon substrate. Each unit cell in the pattern contains different shapes as shown in the SEM image in Figure 6a. The tapered arms of crosses and ribbons shrink to reach a nominal minimum feature size of 20 nm. Figure 6b shows a FM-AFM image of the 1 µm × 1 µm scan area corresponding to the

• KIMEC detection principle allows for AFM imaging with increased pixel acquisition rate (measurement bandwidth) without degrading force sensitivity. (a–c) Scanning electron micrograph of the probe, featuring a Si–N triangular cantilever released from the Si substrate, hosting an integrated lumped-element

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• has emerged as a key contributor to underwater adhesion [16][32]. We previously described recombinant production of the 19 kDa P. pollicipes cement protein (rPpolcp19k) and its adhesion on various substrate chemistries [21]. The protein self-assembled into intertwined amyloid fibres [22] and has the

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• reaction cell was designed to replicate commercial ALD conditions, including independent pulsing of precursor gases, laminar flow across the sample, and substrate heating. The setup allows for independent control of precursor and co-reactant exposure and supports a variety of chemistries [60]. ALD is a key

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• the plate was incubated at 37 °C for 1 hour. The plate was washed and 50 µL/well of diluted detection antibodies was added and incubated for 3 h. The plate was then washed again, the substrate was added, and the plate was incubated at room temperature for 15 min. The reaction was stopped (H2SO4 4 M

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• amount, below which a negative effect is noted. This investigation demonstrates the potential of improving the photoactivity of one-dimensional TiO2 nanostructures by utilizing a highly adsorptive substrate, which can help mitigate the effects of hazardous materials in water. Keywords: carbon cloth

• controlled film thickness of 1.5–4.5 μm, on concurrently activated carbon cloth substrates. The composite film exhibited a high efficiency towards removal of rhodamine B and sulfosalicylic acid in water under UV light illumination, mainly thanks to the highly adsorptive substrate [16]. In the current

• than that of 10–20 ppm adopted by most studies, highlighting the advantages of the one-dimensional TiO2 material on an adsorptive substrate as a photocatalyst. Experimental Materials and reagents Carbon cloth with a purity of 99.8% was provided by Shanghai Hesen Industry Company Limited, China

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• bioresorption in vivo [14]. Zinc has been proposed for use in bioabsorbable vascular stents, demonstrating ideal degradation behavior and mechanical integrity in animal models [51]. AZ31B, along with molybdenum and tungsten, have been investigated as a substrate and conductive layer in transient electronics due

• ) [63][73]. In this process, PI is first coated onto PMMA, followed by photolithographic patterning of the inorganic electronic materials. The PMMA layer is then dissolved, allowing the patterned structure, protected by the thin PI layer, to be transferred onto a desired target substrate. Since the

• electronic devices on a large-area substrate, such as a silicon wafer, followed by backside etching to remove the handle or box layers, thereby isolating the functional thin film for transfer onto a biodegradable substrate. This wafer-level technique offers a promising route to large-area, high-resolution

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• majority of the bound CySH is either coordinated to surface Fe through the amine, or possibly bound to 3,4-DHBA quinones through its thiol. The presence of a higher binding energy feature in the S 2p spectra at >166 eV is attributed to a Si 2s plasmon loss peak, derived from the Si substrate (Supporting

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• comprehensive understanding of the process flow, from the laser-induced ejection of material into the gas phase, through its processing and movement in the plume, to its eventual deposition onto a substrate. Figure 1 shows key developments in thin film synthesis and laser-based processing from 1909 to 2025

• fabrication using nanocolloids synthesized by LPL is given in Figure 9. 2.1 Spin coating The pioneering analysis of spin coating dates back over fifty years to Emslie et al., who first studied the spreading of a thin axisymmetric film of Newtonian fluid on a rotating substrate [100]. In 1989, the method was

• ]. Figure 10a shows a photograph of a typical spin-coating setup, along with high-speed images capturing the dynamics of and film formation on a rotating substrate. Mono and bi-metallic Pt, Pd, and Pt80Pd20 NPs were synthesized using a Nd:YAG laser operating at λ = 1064 nm, a fluence of 5 J/cm2, and a

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• cm−1 peak (Figure 9b) was found to be linear, following the equation y = −2216.3x + 20719, R2 = 0.9943. This linear correlation indicates that the lowest 4-MBA concentration detectable with this AgNPr-based SERS substrate was 10−9 M, confirming its potential for ultrasensitive SERS-based sensing

• SERS substrate enabled detection at concentrations as low as 10−9 M with a strong linear response. These results highlight the potential of LED-synthesized AgNPrs as high-performance, low-cost, and environmentally benign substrates for sensitive SERS applications in chemical and biosensing fields

• residue was re-dispersed in 1 mL of distilled water. 50 µL of 10−4 M 4-MBA solution was added to 450 µL of the re-dispersed sample and left for 1 h at room temperature. 20 µL of the resulting mixture was placed on the Si wafer substrate, allowed to dry at room temperature, and Raman measurements were

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• , which can manifest as a metallic sheen when they are present on a substrate [47]. Surface alterations of the membranes are documented using scanning electron microscopy (SEM) (Figure 4). The CTA membrane’s surface appears smooth and uniform, devoid of visible defects (Figure 4a). Cross-sectional SEM

• the Ag@PCTA membrane illustrate a well-defined PDA layer that maintains its uniformity and adhesion to the underlying CTA substrate (Figure 4f). Notably, Ag nanoparticles are not discernible in the cross-sectional view, indicating their confinement within the PDA layer. The underlying CTA layer

Automated collection and categorisation of STM images and STS spectra with and without machine learning

• Dylan Stewart Barker and
• Adam Sweetman

Beilstein J. Nanotechnol. 2025, 16, 1367–1379, doi:10.3762/bjnano.16.99

• automation of this process could result in a more rapid and reproducible method for performing spectroscopy measurements. To classify the state of the probe for STS experiments, spectra are usually taken over bare areas of a metallic substrate. On coinage metal surfaces, these spectra typically exhibit a

• addition to the lack of data, ML models require careful labelling and a high level of knowledge from the labeller to be able to train such a model. Switching to a new substrate system is likely to require retraining of the model, and furthermore, even after a successful training, it is still often unclear

• that a tip change did not occur during the scan. The obtained topograph is then analysed to find both a large area of clean metal substrate, over which I(V) spectra can be obtained, and to find the location of the molecules in various configurations, over which additional I(V) spectra are taken. After

Deep-learning recognition and tracking of individual nanotubes in low-contrast microscopy videos

• Vladimir Pimonov,
• Said Tahir and
• Vincent Jourdain

Beilstein J. Nanotechnol. 2025, 16, 1316–1324, doi:10.3762/bjnano.16.96

• , horizontally aligned carbon nanotubes (HA-CNTs) were synthesized inside a miniature chemical vapor deposition (CVD) cell with an optical window (Linkam TS1500). ST-cut quartz and iron nanoparticles served as substrate and catalyst, respectively. Ethanol and argon were, respectively, used as carbon precursor

• 400–2000 nm) provided white light excitation across the visible spectrum. Two crossed polarizers were employed, with a polarizer and analyzer used to enhance the scattered field from the nanotubes relative to the stronger reflected field from the substrate. A low-pass optical filter with a cutoff

• cut (ST) quartz substrate and from the fully processed video using (b) fixed-frame and (c) differential shading correction (with a 10 s delay). The thick vertical line in each image indicates the catalyst line. Optical markers (i.e., squares, crosses, and L-shapes) are visible in the corners. CNTs

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• wavelength and decreases with increasing metal conductivity [53]. In the literature, most researchers used high-intensity pulse lasers for works on laser welding and substrate melting [57][58][61][63][64][65][66][67]. However, we could not find any experimental works dedicated to unraveling the penetration

• this. Depth of the patterned substrate at different powers In this section, we investigated the penetration depth of irradiated stainless steel samples across different laser power values, employing a single wavelength of 800 nm. As the power is increased, it is well known that more material from the

• incident power at a wavelength of 800 nm. (a) 20 mW, (b) 150 mW, and (c) 300 mW. Showing the EDS elemental analysis for laser-treated and untreated stainless steel surface. (a) SEM image of laser-treated SS substrate, we picked three areas whose EDS spectra are shown in b, c, and d. (e) SEM image of bare

Enhancing the photoelectrochemical performance of BiOI-derived BiVO₄ films by controlled-intensity current electrodeposition

• Huu Phuc Dang,
• Khanh Quang Nguyen,
• Nguyen Thi Mai Tho and
• Tran Le

Beilstein J. Nanotechnol. 2025, 16, 1289–1301, doi:10.3762/bjnano.16.94

• of ethanol via ultrasonication for 30 min and added to the solution. The FTO glass substrates were cleaned with ethanol and distilled water via sequential ultrasonication. The BiOI film was electrochemically deposited onto the FTO substrate at various current deposition intensities (14, 22, and 32 mA

• of monoclinic BiVO4 (JCPDS PDF #14-0688) and fluorine-doped tin oxide (FTO) substrate (JCPDS PDF #46-1088) [21][22][23]. The peaks at approximately 28.9°, 30.6°, 34.6°, and 35.2° were assigned to the (110), (121), (040), (200), and (002) planes of monoclinic BiVO4, respectively. Notably, the (121