Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

• Camila Felix Vecchi,
• Rafaela Said dos Santos,
• Jéssica Bassi da Silva and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

• , microneedles have been developed to cross the stratum corneum and enable the use of the transdermal route in different therapies [6]. Propolis (PRP) has already been studied in wound healing when incorporated in many vehicles, such as ointments, emulsions, hydrogels, films, or as hydroalcoholic or glycolic

Electrostatic pull-in application in flexible devices: A review

• Teng Cai,
• Yuming Fang,
• Yingli Fang,
• Ruozhou Li,
• Ying Yu and
• Mingyang Huang

Beilstein J. Nanotechnol. 2022, 13, 390–403, doi:10.3762/bjnano.13.32

• electrostatic switches. In addition, Cui et al. [92][93][94][95] showed that the self-powered triboelectrification nanogenerator (TENG) can also be used for human health detection and wound healing. Piezoelectric power generation: Piezoelectric materials can produce very precise tiny motions and have

Morphology-driven gas sensing by fabricated fractals: A review

• Vishal Kamathe and
• Rupali Nagar

Beilstein J. Nanotechnol. 2021, 12, 1187–1208, doi:10.3762/bjnano.12.88

• areas ranging from food packaging to medical diagnosis. Fractals can also help in mimicking the wound healing process as tissue grows to connect the torn skin across the wound and offer an insight into microfluids as part of wound healing management. Besides application-oriented research the

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• polymers to enhance, repair, or replace diseased, damaged, or defective tissue [2]. A few examples are tooth repair, peripheral nerve regeneration, nerve tissue engineering, bone and joint replacement and repair, and regeneration of bone defects, biological scaffolds, and wound healing [3][4][5][6][7][8

• metallohydrogels showed fewer toxicological side effects and were highly biocompatible than Ag+ in the administered dosage range. Furthermore, Fmoc-amino acid metallohydrogels tested under the same conditions showed significantly better wound healing than silver sulfadiazine cream and the control group. It has

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• of nanotechnology. The use carrageenan in nanomaterial synthesis and application has been tabulated in Table 3 [32][110][111][112][113][114][115]. Carrageenan has been complexed with chitosan in a recent study, forming a composite for wound healing dressing. Silver nanoparticles, widely known for

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• %, respectively [207]. Liao et al. fabricated epidermal growth factor-coated lysozyme MBs responsive to US waves, which showed good antimicrobial activity, promoting neovascularization and significantly reducing the time needed for wound healing

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• that there was wound healing of the infected site, while untreated areas resulted in necrotic muscular fibers and bacterial infiltration. Applications of other types of nanoparticles for photothermally induced bacteria and biofilm ablation Besides the widely studied gold nanoparticles, other inorganic

• efficient sterilization upon irradiation during wound healing [92]. The hybrid hydrogel exhibited excellent antibacterial properties against both S. aureus and E. coli under co-irradiation with 660 nm visible light and 808 nm near-infrared light for 10 min, due to the synergistic action of the photodynamic

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

• Mohammad Jaber,
• Asim Mushtaq,
• Kebiao Zhang,
• Jindan Wu,
• Dandan Luo,
• Zihan Yi,
• M. Zubair Iqbal and
• Xiangdong Kong

Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96

• nanocomposites may also have potential to be used in wound healing, photocatalytic and toxic dye removal applications. X-ray diffraction (XRD) patterns of pure TiO2 NPs and Ag–TiO2 nanocomposites at different ratios. SEM and EDS images of the synthesized splat-shaped nanoparticles: (a) pure TiO2 NPs, (b, c) Ag

Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

• Gayathri Kandasamy,
• Elena N. Danilovtseva,
• Vadim V. Annenkov and
• Uma Maheswari Krishnan

Beilstein J. Nanotechnol. 2020, 11, 354–369, doi:10.3762/bjnano.11.26

• polyplex) containing a final concentration of 100 nM siRNA and incubated for specified periods of time. The cells were imaged using an inverted microscope to observe the effect of the treatment on the tubular network. Migration analysis Wound healing assay: To evaluate the gene silencing effect of the

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

• Elisabetta Esposito,
• Maddalena Sguizzato,
• Markus Drechsler,
• Paolo Mariani,
• Federica Carducci,
• Claudio Nastruzzi,
• Giuseppe Valacchi and
• Rita Cortesi

Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174

• ][3]. In the last two decades, the noxious effect of CS on skin has been well demonstrated [4][5][6]. For instance, the chronic exposure of skin to CS induces premature skin ageing, delayed wound healing, psoriasis and inflammatory skin diseases [3]. CS increases the risk of squamous cell carcinoma

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• alternative treatment method for injuries of hollow organs, e.g., vessels, offering faster procedure time, immediate watertightness, faster wound healing and reduced recovery time compared to classical microsuturing [3][4][5]. This technique makes use of a degradable polymer scaffold containing albumin and

Effect of electrospinning process variables on the size of polymer fibers and bead-on-string structures established with a 2³ factorial design

• Paulina Korycka,
• Adam Mirek,
• Katarzyna Kramek-Romanowska,
• Marcin Grzeczkowicz and
• Dorota Lewińska

Beilstein J. Nanotechnol. 2018, 9, 2466–2478, doi:10.3762/bjnano.9.231

• technologies, as well as in new fields of scientific and industrial interest. They are considered to be potentially useful in areas such as nanoelectronics, medicine (e.g., wound healing, tumor therapy, inhalation therapy), filtration processes, textile manufacture, nanocatalysis production, etc. [5][6

Bioinspired self-healing materials: lessons from nature

• Joseph C. Cremaldi and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2018, 9, 907–935, doi:10.3762/bjnano.9.85

• and died to desiccation at the surface [36]. Figure 7B shows an example of wound healing where a tree limb has been removed [72]. The cells at the wound (cut) harden to seal off the tree. After a period of time, the callus growth tissue overtakes the wound as it grows from the wound’s edge, creating

Humidity-dependent wound sealing in succulent leaves of Delosperma cooperi – An adaptation to seasonal drought stress

• Olga Speck,
• Mark Schlechtendahl,
• Florian Borm,
• Tim Kampowski and
• Thomas Speck

Beilstein J. Nanotechnol. 2018, 9, 175–186, doi:10.3762/bjnano.9.20

• mechanically driven mechanism. Subsequent to the relatively fast initial self-sealing processes, self-healing including biosynthesis and cell proliferation starts, and hence the formation of a specific wound healing tissue. After a few weeks, self-healing is completed showing pronounced healed tissue in the

Luminescent supramolecular hydrogels from a tripeptide and nitrogen-doped carbon nanodots

• Maria C. Cringoli,
• Slavko Kralj,
• Marina Kurbasic,
• Massimo Urban and
• Silvia Marchesan

Beilstein J. Nanotechnol. 2017, 8, 1553–1562, doi:10.3762/bjnano.8.157

• system could be valuable for the development of wound healing applications [28], whereby luminescence could be advantageous to visually track the presence of the hydrogel and the ability of its components to penetrate through the derma [29]. In addition, peptide hydrogels based on the Phe-Phe motif [30

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• to be oriented by the ECM [181][182]. Recently, it has been demonstrated in mice that Schwann cells are guided by blood vessels [183]. In wound healing, another important biological process, cells are guided by the ECM to migrate towards the affected area for regeneration and healing [184]. To date

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

• Sylwia Kuśnieruk,
• Jacek Wojnarowicz,
• Agnieszka Chodara,
• Tadeusz Chudoba,
• Stanislaw Gierlotka and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

• production of toothpaste formulations and to speed up wound healing. There are patches and ointments using the unique properties of HAp that were developed by scientists in Poland [7]. Hydroxyapatite has also received great interest in the regeneration of animal bone loss. It has been proved that HAp

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

• Tudor Braniste,
• Ion Tiginyanu,
• Tibor Horvath,
• Simion Raevschi,
• Serghei Cebotari,
• Marco Lux,
• Axel Haverich and
• Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

• a living organism, angiogenesis has an important role in the wound healing process, where new blood vessels are being formed from pre-existing ones [9]. It is widely believed that endothelial cells communicate to each other and, as a result of their communication and redistribution, form hollow

Tattoo ink nanoparticles in skin tissue and fibroblasts

• Colin A. Grant,
• Peter C. Twigg,
• Richard Baker and
• Desmond J. Tobin

Beilstein J. Nanotechnol. 2015, 6, 1183–1191, doi:10.3762/bjnano.6.120

• nanoparticle of tattoo ink pigment in the region of 40 nm diameter was visualised from a dermal section of tattooed skin. The strong parallel orientation of the collagen fibrils was also noted in the tattooed skin, which was consistent with previous findings in wound healing/scar tissue [25]. Fibroblasts that

Increasing throughput of AFM-based single cell adhesion measurements through multisubstrate surfaces

• Miao Yu,
• Nico Strohmeyer,
• Jinghe Wang,
• Daniel J. Müller and
• Jonne Helenius

Beilstein J. Nanotechnol. 2015, 6, 157–166, doi:10.3762/bjnano.6.15

• or spreading experiments on different proteins could be conducted using PDMS masks. Further examples where masks could be used include wound-healing assays and experiments that require more complex surfaces. Experimental Production of PDMS masks To produce the PDMS masks, a casting mold with cavities

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

• Christina Rosman,
• Sebastien Pierrat,
• Marco Tarantola,
• David Schneider,
• Eva Sunnick,
• Andreas Janshoff and
• Carsten Sönnichsen

Beilstein J. Nanotechnol. 2014, 5, 2479–2488, doi:10.3762/bjnano.5.257

• nanoparticle infiltration into a tissue lesion or by insertion of nanoparticle patterned implants. This can potentially influence cell migration, which has implications in wound healing [13]. Recently, a study by Yang et al. tracked the migration behavior of prostate carcinoma cells (PC3, epithelial) and human

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

• Christina Sengstock,
• Jörg Diendorf,
• Matthias Epple,
• Thomas A. Schildhauer and
• Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

• nanomaterials have been used in numerous devices and products, such as silver sulfadiazine in the treatment of burns to reduce skin infections. Furthermore, silver has been used to coat a variety of different surfaces, such as catheters [4][5][6][7], or it has been incorporated into a hydrogel network for wound

• healing [8]. In our previous studies on the biological effects of Ag-NP (PVP-coated, 80 nm) on human mesenchymal stem cells (hMSCs), we have shown that cell activation could occur at elevated but non-toxic silver concentrations [9][10]. In addition, we have shown that hMSCs are able to ingest Ag-NP

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

• Claudia Strobel,
• Martin Förster and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

• studies reported the presence of anti-oxidative [16][17][18][19], neuroprotective [20], cardioprotective [21], anti-inflammatory [22] and radioprotective properties [23]. Moreover, CeO2 nanoparticles fostered wound healing in mice due to reduction of oxidative damage [24]. However, in other studies an