Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• mechanism, facilitating cytosolic delivery with reduced cytotoxicity. This approach offers a safer and more effective option for targeted drug delivery applications. Keywords: Aurein 1.2; endosomal escape; fusogenic effect; molecular dynamics simulation; sodium oleate; Introduction The quest for efficient

• localized membrane destabilization [23]. Furthermore, our results correlate with studies proposing a detergent-like mechanism, where AUR induces high local curvature, disrupting membrane integrity without fully spanning the membrane [24]. To further elucidate effects on membrane structure and dynamics, we

• new strategies in targeted drug delivery. Proposed mechanism of sodium oleate-enhanced endosomal escape in drug delivery In this study, we developed an innovative strategy to modify liposomes with SO to enhance their endosomal escape capabilities. By combining in vitro experiments with in silico MD

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

• Julia E. Poletaeva,
• Anastasiya V. Tupitsyna,
• Alina E. Grigor’eva,
• Ilya S. Dovydenko and
• Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

• . When incubated in the dark, PACL binds to the thiol groups of serum proteins (i.e., it modifies them). The reaction mixture is then irradiated with UV, under the action of which the nitroaryl azide group covalently fixes the modified proteins on the surface of the NPs. This mechanism has been

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation

• Abhishek Das,
• Mangababu Akkanaboina,
• Jagannath Rathod,
• R. Sai Prasad Goud,
• Kanaka Ravi Kumar,
• Raghu C. Reddy,
• Ratheesh Ravendran,
• Katia Vutova,
• S. V. S. Nageswara Rao and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1639–1653, doi:10.3762/bjnano.15.129

• mbar) using an electron beam melting furnace having a beam power of 60 kW (ELIT 60) at an accelerating voltage of 24 kV in a water-cooled crucible with feeding mechanism and an extraction system [32]. All operations were conducted at the Centre for Materials for Electronics Technology (CMET), Hyderabad

Heterogeneous reactions in a HFCVD reactor: simulation using a 2D model

• Xochitl Aleyda Morán Martínez,
• José Alberto Luna López,
• Zaira Jocelyn Hernández Simón,
• Gabriel Omar Mendoza Conde,
• José Álvaro David Hernández de Luz and
• Godofredo García Salgado

Beilstein J. Nanotechnol. 2024, 15, 1627–1638, doi:10.3762/bjnano.15.128

• . Different tools such as ab initio density functional theory [13][14], kinetic Monte Carlo simulations [15][16], and reactive molecular dynamics simulations [17][18] have been used to understand the chemical reactions underlying the growth of the films [19]. Modeling the reaction mechanism in both two

• -dimensional (2D) and three-dimensional (3D) systems is a tool that allows us to understand the key steps regarding the reproducibility and uniformity of the films [19][20]. From a computational point of view, prior works focused on the growth mechanism of SiOx in a plasma-enhanced chemical vapor deposition

• exhibited greater photoluminescence compared to those that did not undergo thermal treatment [29]. The SiO species plays an important role in the proposed mechanism; the reaction of SiO with •OH and •H radicals leads to the formation of HSiO and silanes [15]. Silane and silanol species were also found in

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• delivery due to their protective mechanism against harmful endogenous and exogenous substances through transcellular pathways. The BBB selectively permits molecules smaller than 400 Da with specific shapes, ionization states, and lipophilicity, thereby excluding macromolecular drugs and those with

• chemodynamical therapy (CDT): the high presence of reducing species (GSH) inhibit the therapeutic effects of CDT in tumors [78]. By releasing metal cations in the early stages to consume the reducing substances, these nanocarriers enhance therapeutic efficacy of CDT. This mechanism has also been applied to

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• , unlike their complexes. All agents exert a hypolipidemic effect by lowering LDL, despite maintaining the synthetic functions of the liver. Fe3O4 NPs increase the activity of GPO, which is associated with their peroxidase-like properties. A multifaceted and diverse mechanism of action of all studied

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol

• Akash Kumar,
• Ridhima Chadha,
• Abhishek Das,
• Nandita Maiti and
• Rayavarapu Raja Gopal

Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124

• grafting magnetic nanoparticles with ʟ-carnosine significantly enhanced the catalytic performance of the nanoparticles [15]. In another study, metal-organic framework nanoparticles fabricated with ʟ-carnosine were employed for arsenic removal via an adsorption mechanism. The maximum removal of arsenic was

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• nanoparticles in controlling vector mosquitoes [62]. AgNPs synthesized from seaweed have been investigated as a vector control strategy based on their larvicidal properties. Table 2 summarizes data from bioassays with AgNPs synthesized from different species of seaweed against A. aegypti larvae. The mechanism

• nanoparticles via green synthesis and their larvicidal activity against A. aegypti, some challenges still persist. Aspects such as the mechanism of action of AgNPs in the different stages of A. aegypti, resistance of mosquitoes to larvicides, and the long-term effects of NPs on non-target organisms still need

Ultrablack color in velvet ant cuticle

• Vinicius Marques Lopez,
• Wencke Krings,
• Juliana Reis Machado,
• Stanislav Gorb and
• Rhainer Guillermo-Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122

• a light-trapping mechanism and can enhance absorption by 5% compared to a flat surface. The dense layer of black epicuticular setae further enhances ultrablack coloration. Ishay and collaborators [22] suggested that longitudinal chitinous plates would be interconnected by dark transverse and

Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection

• Thi Kim Ngan Nguyen,
• Tien Dat Doan,
• Huy Hieu Luu,
• Hoang Anh Nguyen,
• Thi Thu Ha Vu,
• Quang Hai Tran,
• Ha Tran Nguyen,
• Thanh Binh Dang,
• Thi Hai Yen Pham and
• Mai Ha Hoang

Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120

• electrochemical reaction mechanism of ENR is irreversible. The experimental results are consistent with previous studies [16][43][44]. Besides, the ENR peak obtained on (Cu)(Fe)BTC was much higher than those on CPE, CuBTC@CPE, and FeBTC@CPE, likely because of the catalytic properties of two MOF materials in the

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• crucial for maintaining therapeutic drug levels over extended periods of time [20][21]. By adjusting the polymer composition and lipid matrix, researchers can fine-tune the release kinetics of phytochemicals, ensuring sustained therapeutic effects. This controlled release mechanism is particularly

• against HCT-116 cells, in terms of apoptosis and cell cycle arrest, was assessed using flow cytometry. Comparison with APN suspension showed significant improvements favoring APN-PLHNPs. Additionally, the anticancer mechanism was further explored by examining the gene expression of key signaling molecules

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• the self-diffusion coefficients in a monovacancy mechanism mediated by nearest-neighbor vacancy jumps [26][27]. It is important to note that Shen’s approach assumes a size-dependence of the vacancy concentration in the steady-state regime (Equations 15 and 16), that is, the concentrations are

• K), regardless of whether the material is irradiated or not (indicating instability of the initial bcc phase). In this zone, the dominant mechanism is not radiation but rather surface effects associated with a decrease in surface energy during the phase change. Consequently, both functions Δg and

Ion-induced surface reactions and deposition from Pt(CO)₂Cl₂ and Pt(CO)₂Br₂

• Mohammed K. Abdel-Rahman,
• Patrick M. Eckhert,
• Atul Chaudhary,
• Johnathon M. Johnson,
• Jo-Chi Yu,
• Lisa McElwee-White and
• D. Howard Fairbrother

Beilstein J. Nanotechnol. 2024, 15, 1427–1439, doi:10.3762/bjnano.15.115

• performance of Pt(CO)2Cl2 and Pt(CO)2Br2 as Pt precursors and comparing the differences in H2+-, He+-, and Ar+-induced Pt deposition. To determine precursor and ion identity effects on the deposition mechanism, we employ a surface analysis approach under UHV conditions to determine the ion-induced

• /cm2 Ar+ dose was required to completely remove Br from PtBr2. Since ion beam-induced physical sputtering is driven by a momentum/energy transfer mechanism with a dependence on the mass ratio between the ion and target [69][70][71][72], this difference can attributed to the better mass match between Ar

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• morphological and functional innovations predominantly involve the slender waist of Apocrita wasps, the stinging mechanism observed in Aculeata, parasitoidism (a specialized form of carnivorous behavior), and secondary phytophagy (a reversion to plant-based feeding) [7]. Hymenoptera are also well known as the

• feature observed in ensign wasps (Afrevania and Trissevania, Evaniidae) [110]. These wasps exhibit a sophisticated ability to fold their forewings along two intersecting fold lines, creating a four-plane wing folding mechanism [110]. By incorporating a similar four-plane wing folding mechanism, drones

• applications for the development of micro-aerial vehicles [118][119]. The wing-to-wing coupling mechanism in Hymenoptera functions as a multifaceted joint, linking the forewing’s rolled membrane to the hindwing’s hook structures, enabling synchronized movement and improved aerodynamic performance [121][122

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• the shorter nanorods. The mechanism is similar to the interaction of metals with longer nanorods. However, the change in metal selectivity is due to the size of nanorods. In NaOH absence, no metal shows prominent interaction with centrifuged CTAB-AuNR21.0 and AuNR20.5 (Supporting Information File 1

• detection. Table 2 summarizes various studies on detecting heavy metals using CTAB-capped metal nanoparticles via linkers or buffers. Table 2 includes detected metals using as-prepared/centrifuged CTAB-capped AgNS, AuNS, AuNR1, and AuNR2. Possible mechanism of heavy metal detection Previous studies have

• mechanism in this study is influenced by factors such as the amount of NaOH, nanoparticle shape, and nanoparticle concentration. As previously reported, CTAB-capped silver nanospheres detected Cu2+ and Hg2+, attributed to the interaction between the metal ions and the nanoparticles. The underlying mechanism

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• -selective feeding mechanism, which transports particles in the size range from 0.5 to 3 μm to the intestinal lumen [59][60]. Therefore, even at higher doses, we did not observe a linear relationship between C. elegans’ survival and the material’s concentration. Considering this, we evaluated the effects of

Mn-doped ZnO nanopowders prepared by sol–gel and microwave-assisted sol–gel methods and their photocatalytic properties

• Cristina Maria Vlăduț,
• Crina Anastasescu,
• Silviu Preda,
• Oana Catalina Mocioiu,
• Simona Petrescu,
• Jeanina Pandele-Cusu,
• Dana Culita,
• Veronica Bratan,
• Ioan Balint and
• Maria Zaharescu

Beilstein J. Nanotechnol. 2024, 15, 1283–1296, doi:10.3762/bjnano.15.104

• to examine the photocatalytic mechanism under different irradiation sources. Also by the sol–gel method, the active materials can be deposited in future studies as films on different supports for better surface contact and recovery degree, enhancing the scale-up opportunity for water cleaning

New design of operational MEMS bridges for measurements of properties of FEBID-based nanostructures

• Bartosz Pruchnik,
• Krzysztof Kwoka,
• Ewelina Gacka,
• Dominik Badura,
• Piotr Kunicki,
• Andrzej Sierakowski,
• Paweł Janus,
• Tomasz Piasecki and
• Teodor Gotszalk

Beilstein J. Nanotechnol. 2024, 15, 1273–1282, doi:10.3762/bjnano.15.103

• actuation mechanism. This opens the possibility to perform both electrical and mechanical measurements of nanostructures, in particular, free-standing nanostructures, which are the most interesting for their mechanical and electrical properties combined in nanoscale phenomena [28][29][30]. The requirements

• for the desired MEMS measurement platforms are as follows: They should be dimensionally compatible with the nanostructure to be tested and allow for actuation with an embedded actuation mechanism. To operate, MEMS platforms require auxiliary equipment such as a scanning electron microscope (SEM) or

• device, as has been shown in the case of FIB origami [46]. More recently, Masteghin et al. have shown how strain engineering and eigenstrain modification can influence single-material MEMS devices [47]. The exact mechanism depends on the ion and substrate materials, but surface amorphisation or material

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• synthesizing gold nanoparticles (AuNPs) within a glucosamine/alginate (GluN/Alg) nanocomposite via an ionotropic gelation mechanism in aqueous environment. The resulting nanocomposite, AuNPs@GluN/Alg, underwent thorough characterization using UV–vis, EDX, FTIR, SEM, TEM, SAED, and XRD analyses. The spherical

• Au3+ into Au(0) during the synthesis of the nanocomposite AuNPs@GluN/Alg without additional chemicals. Alginate serves as a stabilizing agent. In the ionotropic gelation mechanism, the cross-linking matrix of Ca–alginate, formed by Ca2+ ions and carboxyl groups in sodium alginate, becomes insoluble

• mechanism involves the transfer of electrons from BH4− (the electron donor) to the dye (the electron acceptor) facilitated by the surface of the metal nanoparticles [42][43]. Prior to electron transfer, dye and BH4− are adsorbed onto the catalyst surface, as depicted in Figure 5. Consequently, the

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• ) designed to transport therapeutic agents with precise delivery to tumor sites. This approach aims to mitigate toxic effects associated with off-target drug delivery and optimize therapeutic efficacy. For decades, the enhanced permeability and retention (EPR) effect has stood as the central mechanism for

• were 8–10 nm in size and exhibited efficient renal clearance, with over 90% ID found in the urine at 72 h p.i. Such a high clearance rate was unexpected considering the larger size of the construct compared to the kidney filtration barrier, and the underlying mechanism for this phenomenon requires

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• drug doxorubicin (DOX) has been used in the present study. It is a known antitumor antibiotic of the anthracycline series, which has been approved as anticancer drug in 1974. It has antimitotic and antiproliferative effects. The mechanism of action is interaction with DNA, the formation of free

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• are mostly designed to serve as chemotherapy agents for breast cancer. Thus, it is possible to assume that several drugs share a common mechanism of action and, subsequently, a common protein target, such as CXCR7. For instance, gemcitabine, shown in Figure 2, shares the pocket within CXCR7 with

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• radius of the nanomaterial components but positively by the molecular bulk of the nanomaterials. Electronegativity and atomic size determine the reactivity and contact strength of nanomaterials with biological systems, whereas the molecule bulk affects the mechanism of inhibition through steric effects

• testing methods for chemical safety assessments. Scatter plot (a) and Williams plot (b) for the nano-qRASTR model. The red dashed line indicates the highest Hat or leverage value, that is, the h* cut-off line. SHAP plot for the nano-qRASTR model. Mechanism of zebrafish hatching enzyme inhibition by MONPs

Photocatalytic methane oxidation over a TiO₂/SiNWs p–n junction catalyst at room temperature

• Qui Thanh Hoai Ta,
• Luan Minh Nguyen,
• Ngoc Hoi Nguyen,
• Phan Khanh Thinh Nguyen and
• Dai Hai Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1132–1141, doi:10.3762/bjnano.15.92

• reactor. Plausible charge transport mechanism Figure 8 shows a schematic mechanism of the photocatalytic activity of the p–n TiO2/SiNWs hierarchical structures. According to previous studies the energy bandgaps of p-Si and n-type TiO2 were assumed to be 1.1 eV and 3.3 eV, respectively [54][55][56

• Aderson’s model [39]. The photogenerated electrons tend to produce C2H6, C3H8, and H2 from H+. The photogenerated holes at the VBM of TiO2 create oxidized intermediates and H+ [59][60][61]. The whole process can be expressed by the S-scheme mechanism, as follows: at the CB of n-type TiO2 and at the VB of

• over the TiO2/SiNWs sample. Proposed mechanism of photocatalytic CH4 oxidation reaction over p–n junction TiO2/SiNWs sample. Schematic illustration of TiO2/SiNWs chip fabrication starting from a p-type silicon wafer. A thin layer of TiO2 was deposited on the Si NWs via ALD. Comparison of the OCM

Direct electron beam writing of silver using a β-diketonate precursor: first insights

• Katja Höflich,
• Krzysztof Maćkosz,
• Chinmai S. Jureddy,
• Aleksei Tsarapkin and
• Ivo Utke

Beilstein J. Nanotechnol. 2024, 15, 1117–1124, doi:10.3762/bjnano.15.90

• elemental silver at the bottom, the formation mechanism of which deserves further investigation. Experimental FEBID was carried out in a Hitachi S3600 tungsten filament scanning electron microscope (SEM). The precursor compound trimethylphosphine(hexafluoroacetylacetonato)silver(I), short (hfac)AgPMe3

• silver deposition with a focused electron beam, such non-uniform deposit structures have not been observed before. The mechanism of the interfacial silver layer formation in our case may include several factors. One factor may be the presence of water. In the typically used high-vacuum range of 10−4 Pa

• the formation mechanism of the interfacial silver layer deserves further in-depth studies, which are beyond the scope of this article. These studies would involve surface science approaches using mass spectrometry and/or other spectroscopic techniques, such as X-ray photoelectron spectroscopy, and