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Search for "cancer" in Full Text gives 306 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Evaluation of click chemistry microarrays for immunosensing of alpha-fetoprotein (AFP)
Beilstein J. Nanotechnol. 2019, 10, 2505–2515, doi:10.3762/bjnano.10.241
- (AOC), Karlsruhe Institute of Technology (KIT), Engesserstraße 15, 76131 Karlsruhe, Germany 10.3762/bjnano.10.241 Abstract The level of cancer biomarkers in cells, tissues or body fluids can be used for the prediction of the presence of cancer or can even indicate the stage of the disease. Alpha
- was spotted onto them via microchannel cantilever spotting (µCS). Based on the fluorescence measurements, the optimal microarray design was found and its sensitivity was determined. Keywords: alpha-fetoprotein (AFP); cancer biomarker; click chemistry; fluorescent immunosensor; hepatocellular
- carcinoma; Introduction Hepatocellular carcinoma (HCC) is the major cause of morbidity and mortality in patients with chronic liver disease, the sixth most common cancer and the fourth leading cause of cancer-related deaths worldwide. The last release of the Global Cancer Observatory (GCO) database in
Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods
Beilstein J. Nanotechnol. 2019, 10, 2483–2496, doi:10.3762/bjnano.10.239
- green is highly toxic for aquatic animals or mammals and can induce cancer in animals. Thus, MG is significantly detected at low concentrations in water. The maximum concentration of malachite green is less than 2 μg/kg (5.48 × 10−9 mol/L) for many national food safety standards. Pesticide residues in
Small protein sequences can induce cellular uptake of complex nanohybrids
Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238
- have also been discussed [12][14][15]. More recently, there have been a few reports discussing the use of luminescent Eu-loaded hydroxyapatite nanocrystals for rapid HeLa cancer cell imaging [9][11][16], or the nanostructure self‐assembly driven by amino acid coordination to increase the biological
pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging
Beilstein J. Nanotechnol. 2019, 10, 2428–2439, doi:10.3762/bjnano.10.233
- contrast to acidic pH conditions where the fluorescent intensity is absent or low. No increase in the absorption was observed when the suspension pH was increased from 7 to 10. The functionalized BNNTs are easily taken up by human normal prostate epithelium (PNT1A) and human prostate cancer cell lines
- obtained with a Carl Zeiss Evo-40 instrument under high vacuum and accelerating voltage of 10 kV. Cell culture experiments Normal prostate epithelium (PNT1A) and human prostate cancer (DU145) cell lines were grown in Dulbecco’s Modified Eagle’s Medium, supplemented with 10% fetal bovine serum and 1
- intracellular pH values are often associated with cell dysfunction and are observed in diseases such as cancer [58] and Alzheimer’s [59]. Therefore, information on intracellular pH is a crucial factor in understanding the physiological and pathological processes within living cells. In our previous work, BNNTs
Multiwalled carbon nanotube based aromatic volatile organic compound sensor: sensitivity enhancement through 1-hexadecanethiol functionalisation
Beilstein J. Nanotechnol. 2019, 10, 2364–2373, doi:10.3762/bjnano.10.227
- of trace concentrations of toluene in exhaled breath is associated with lung cancer and can therefore be considered as a biomarker for this pathology [2][3][4]. A gas sensor is generally composed of an active sensing film or material deposited on an electrode. The sensing performance is strongly
Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects
Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222
- activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were
- 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while
- selectivity targeting cancer cells. Keywords: curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407; Introduction The development of nanostructured systems containing poloxamer 407 (P407) and Carbopol 974P® (C974P) have previously been shown to have rheological and mechanical
Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields
Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221
- ][3][19][20], certain thermal effects in combination with radiotherapy or chemotherapy can significantly improve the results of cancer treatment. One of the main technological problems of current magnetic hyperthermia development is the optimal choice of sizes and magnetic parameters of nanoparticles
- and analytical calculations. This topic has recently attracted considerable interest [33][34][35][36][37][38][39][40][41][42][43] in view of the possibility of using magnetic nanoparticles in magnetic hyperthermia for the cancer treatment. Unfortunately, in experiments [41][43] very small SAR values
Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation
Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214
- /HYPS was applied as the support. An in vitro experiment was conducted to determine the potential of CuFe2O4/HYPS as an anticancer agent against the human breast cancer cell line MCF-7. The results show that the nanoparticle formulation can effectively target cancerous cells and could be an effective
- have been broadened in terms of chronic cancer, diabetic and other metabolic disorders. The global burden of cancer is expected to affect about 24 million people by 2035. The robust technological advancements in utilizing nanoparticles for therapeutic applications are the new hope to circumvent the
- materials have been reported to be effective for cancer therapeutics [3][4]. However, due to the poor crystallinity of SPIONs on silica supports, a low saturation value of magnetization occurs in the silica bound nanocomposites. For instance, the magnetometer (superconducting quantum interference device
Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors
Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210
- Carlos 13560-970, São Paulo, Brazil Chemistry Department, Federal University of Paraná, Curitiba, 81531-980, Paraná, Brazil 10.3762/bjnano.10.210 Abstract Diagnosis of cancer using electroanalytical methods can be achieved at low cost and in rapid assays, but this may require the combination with data
- -linked immunosorbent assay. The approaches for immunoassays and data processing are generic, and therefore the strategies described here may provide a simple platform for clinical diagnosis of cancers and other types of diseases. Keywords: cancer biomarkers; magnetite nanoparticles; microfluidic devices
- ; nanoarchitectonics; information visualization; sandwich-type immunosensors; screen-printed electrodes; Introduction The prostate-specific antigen (PSA) used in clinical diagnosis is present in normal prostatic secretions, but its concentration is often elevated in prostate cancer patients. In spite of its lack of
Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications
Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207
- the singlet state. Magnetic nanoparticles (MNPs) can act as contrast agents [16] to improve the imaging of tumors in specific cancer MRI. Multimodal imaging has been recently made possible by functionalizing the particle surface with biocompatible chemicals, where surface coverings (such as the
- whose features are used in many technologies, from magnetic information storage to ferrofluids or nanoscale drug-delivery systems and magneto-assisted hyperthermia cancer treatments [65]. Single SPION detection with 10 nm accuracy was shown by bulk diamond NV center magnetometry combining spin
Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201
- . The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results
- an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells. Keywords: cancer; doxorubicin; drug release
- ; nanoparticles; poly(lactic-co-glycolic acid) (PLGA); Introduction According to Globocan, there “were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within five years of diagnosis) in 2012 worldwide” [1]. Despite substantial improvements over recent decades
Review of advanced sensor devices employing nanoarchitectonics concepts
Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198
- nanoarchitectonics strategy could be applied for the sensing of various bio-related substances and may become useful for diagnostics of diseases such as cancer. Sensors that are used to detect environmental risks mostly require detection of metal ions and toxic ions. Akamatsu et al. developed an optode-type sensor
- could be applicable for demands requiring the evaluation of small normal pressures even on dynamic surfaces such as natural tissues and is expected to be useful for in situ biomedical digital monitoring, such as palpation for breast cancer. Triboelectric nanogenerators to convert mechanical energy to
- electron mobility transistors were used to dynamically monitor changes in the transmembrane potential, as reported by Lee, Wang, and co-workers [110]. Here, circulating tumor cells of colorectal cancer together with cellular bioelectric signals were investigated. The proposed sensor design would also be
Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells
Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189
- Liang Xu Dekang Xu Ziying Li Yu Gao Haijun Chen Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116
- and synthesized, aiming to discover new steroid-based antitumor agents. In this work, we synthesized several Di derivatives and screened FZU-0021-194-P2 (P2), which showed more potent cytotoxic activities against human non-small-cell lung cancer A549 and PC9 cells. Considering that Di has a unique
- sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more
Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting
Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181
- ) diseases, such as glioblastoma [4]. On one hand, given the lack of sensitivity in conventional MR imaging, the development of molecular MR imaging of tumor biomarkers is highly urgent for noninvasive, visual presentation of cancer aggressiveness and guidance of glioblastoma excision [5]. In addition
- for sensitive characterization and detection of glioblastoma. Compared with single mode imaging, multimodal imaging can facilitate early cancer detection, providing a more comprehensive and multidimensional description of tumor biological behavior [27][28][29]. Optical imaging enables the
Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release
Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177
- cancer such as prostate and cervical cancers [3]. However, the therapeutic application of curcumin is limited by its high hydrophobicity with poor water solubility, photosensitivity, chemical instability, and rapid metabolism rate [4][5]. Therefore, as a result, systemic bioavailability is much reduced
- surfactants prepared by the solvent evaporation method, Xu et al. were able to achieve around 92% loading efficiency of curcumin and measured enhanced cytotoxic activity against ovarian cancer cells compared with freely dispersed curcumin [9]. Microfluidic mixing is a recently developed method for the
Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints
Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176
- recognition of human cells. Viral and chemical transformation of cells induce changes in the architecture of the membrane [38], and tumor cells have many more microvilli than non-dividing normal cells [39]. These differences in the surfaces characteristics of cancer and normal cells can potentially be used
Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione
Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175
- nanoparticles (AuNPs) range from molecular imaging, targeted drug delivery, gene therapy, cancer treatment or radio-sensitization and theranostics [1][4][6]. Moreover, AgNPs and AuNPs are among the most investigated engineered nanomaterials for medical use. A search performed in the Web of Science (WoS
Lipid nanostructures for antioxidant delivery: a comparative preformulation study
Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174
- air quality all over the world. Besides being the primary cause of many respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma and lung cancer), pollution is also responsible for cutaneous pathologies, spanning from skin aging, inflammation and allergy to skin cancer [1]. Cigarette
- smoke (CS) is one of the major toxic pollutants, exerting an important role in the onset of many serious and fatal diseases. Indeed, it is well known that CS can provoke various pathologies especially related to the lungs (e.g., cancer, emphysema, bronchitis) as well as the cardiovascular apparatus [2
- , with respect to non-smokers, as well as oral leukoplakia and oral cancers, such as lip cancer. Indeed, tobacco smoke is constituted of thousands of toxic compounds, including benzene, formaldehyde, hydrogen cyanide, carbon monoxide, arsenic and radioactive components, producing free radicals that cause
Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells
Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166
- body distribution of its many substrates including drugs, xenobiotics, and other molecules. HSA nanoparticles may provide an alternative, more specific way to overcome transporter-mediated resistance. Keywords: ABCB1; cancer; doxorubicin; drug resistance; human serum albumin; nanoparticles
- ; transporter; Introduction According to Globocan there "were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide" [1]. Despite substantial improvements over recent decades, the prognosis for many cancer patients
- limited by therapy resistance [2][3][4]. Drug efflux mediated by transporters including adenosine triphosphate (ATP)-binding cassette (ABC) transporters has been shown to play a crucial role in cancer cell drug resistance [2][5]. ABCB1 (also known as P-glycoprotein or MDR1) seems to play a particularly
Materials nanoarchitectonics at two-dimensional liquid interfaces
Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153
- sophisticated strategy to realize chemotherapy targeting at cancer cells using the controlled assembly and disassembly of layer-by-layer hybrid structures made of two dimensional MoS2 nanosheets with DNA [87]. The preparation of functional low-dimensional materials requires preservation of nanoscale features in
The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133
- ) and especially magnetic hyperthermia therapy, which is one of the efficient and new approaches for cancer treatment [4][15]. When magnetic NPs concentrated in tumor tissue are exposed to an ac magnetic field, the electromagnetic energy is converted into thermal energy, and the generated heat is used
- to destroy cancer cells through the elevated temperatures [16][17]. The heating efficiency of the NPs as heat sources under ac magnetic fields is often denominated as specific absorption rate (SAR), which is directly related to the area of the magnetic hysteresis loop of the nanoparticles by the
On the relaxation time of interacting superparamagnetic nanoparticles and implications for magnetic fluid hyperthermia
Beilstein J. Nanotechnol. 2019, 10, 1280–1289, doi:10.3762/bjnano.10.127
- nanoparticulate contrasting agents on proton relaxivity [7][8][9]) and cancer therapy (through magnetic fluid hyperthermia therapy [10][11]). The efficiency of the magnetic nanoparticles (MNPs) in a colloidal system to convert the energy of AC magnetic fields into temperature increments is of high importance for
- -transfer equation which is of key interest in the optimization of cancer therapy by magnetic hyperthermia therapy [19]. The second option may be effective in exploiting the theoretical models proposed for linking the experimental SAR dependencies to the physical mechanisms. From the theoretical point-of
Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108
- stress, inflammation, aging in general, and the development of fatal diseases, such as cancer, neurodegenerative disorders, atherosclerosis, heart failure, myocardial infarction, and infections. ROS of radical origin (superoxide and hydroxyl) are particularly harmful because they initiate oxidative chain
Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates
Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104
- different molar fractions of FluPep ligand. Supporting Information Supporting Information File 94: Additional experimental data. Acknowledgements Zaid K Alghrair was supported by a PhD studentship award from the Iraqi Ministry of Higher Education. DGF is supported by the Cancer and Polio Research Fund
- , and North West Cancer Research. An earlier version of this work was published as a preprint (Alghrair, Z., Fernig, D. G.; Ebrahimi, B. Enhanced inhibition of influenza virus infection by peptide-noble metal nanoparticle conjugates. Biorxiv, 2018; doi:10.1101/324939).
Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101
- assay, zeta potential measurements, and liquid chromatography–mass spectrometry/mass spectrometry (LC–MS/MS). Additionally, the time-dependent cell interaction of PLGA NPs in the absence or presence of a preformed protein corona was assessed by in vitro incubation experiments with the human liver cancer
- proteins was conducted by Bradford assay after alkaline hydrolysis of PLGA–NPs. Finally, the consequences of corona formation on the interaction between NPs and cells were examined by in vitro incubation experiments with the human liver cancer cell line HepG2. Results and Discussion Compositional evolution
- human liver cancer cell line HepG2 was used for in vitro incubation experiments. For an easy tracking of NPs in cell culture experiments, the fluorescent dye Lumogen® Red was incorporated into the hydrophobic particle matrix. Due to the lipophilic properties of the dye molecule an average of 8.14 µg
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