Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• exhibited significant time-dependent leishmanicidal activity against Leishmania amazonensis promastigotes, with lower IC50 values (up to five times lower at 48 hours) and up to 75% parasite death after 48 hours, showing greater antiparasitic activity compared to that of free phytol. Although the use of

• % streptomycin antibiotic (100 IU/mL) at 27 °C. For the tests, cultures were used after the 4th day of supplementation, obtaining parasites at the end of the log phase, that is, with the greatest possible growth potential. Antiparasitic activity of nanoemulsions on Leishmania amazonensis promastigotes To assess

• the antiparasitic activity, Leishmania amazonensis promastigotes after the 4th days of growing in RPMI medium were counted using a Neubauer chamber, diluted in RPMI medium supplemented with 10% FBS and 10% streptomycin antibiotic (100 IU/mL) at 27 °C, and adjusted to a concentration of 1 × 107

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• BNZ at a 353-fold higher dose (100 mg/kg/day over 20 days: 2000 mg/kg TD [52]). The study of the effect of pH-sensitive liposomes for etanidazole delivery to CD models was discontinued, but along with BNZ-polymersomes both showed that ultralow doses of the antiparasitic drug could reduce infection and

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• nanocarriers intended for the treatment of leishmaniasis. Keywords: antiparasitic; Curcuma longa; curcuminoids; leishmaniasis; nanocarriers; neglected tropical diseases; Introduction Neglected tropical diseases (NTDs) comprise a group of 20 diseases that are caused, in most cases, by viruses, fungi, bacteria

• disease continues to be of utmost importance [9]. Current studies have highlighted curcumin as a promising antiparasitic alternative [10]. Curcumin (diferuloylmethane) is a yellow polyphenol extracted from the rhizome of Curcuma longa, popularly known as turmeric [11][12][13]. This molecule presents a

• curc has great potential for the treatment of various diseases in humans [37][38][39]. Among the diverse biological potential of this molecule, its antiparasitic properties against different diseases have attracted considerable attention in recent decades [10][40][41]. Among such, the potential of curc

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• blood samples as was described for other type of nanoparticles [45]. Our results suggest that the reported NLC-BNZ formulations are hemocompatible [43]. In vitro antiparasitic activity As shown in Figure 12A, free BNZ displayed a clear dose-dependent effect on T. cruzi trypomastigotes (with an EC50 of

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• Canadensis [2]. Many studies have shown the pharmacological actions of BBR including antimicrobial [3][4], antiviral [5][6], anti-inflammatory [7] and antiparasitic effects [8], and effects against hyperlipidemia [9], hypoglycemia [10] and cancer [11]. BBR has the ability to inhibit or kill many pathogenic

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• from Staphylococcus aureus) was adsorbed on PGA/PLL film via electrostatic attraction and the in vitro cell contact with this protein mainly occurred via local film degradation [103]. The antitumoral, antitoxic, anticarcenogenic, antifungal and antiparasitic properties of protein A could be a good