Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• . Surface tension Surface tension was measured using the pendant droplet method with a drop-shape analyzer (DAS-100, KRÜSS GmbH, Hamburg, Germany). Microemulsion droplets (17 µL) were formed at the tip of a stainless-steel needle and analyzed by image capture and subsequent software processing to calculate

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• number of beads and the formation of fibers with a more dispersed structure, likely reflecting insufficient polymer chain entanglement and Taylor cone instability. This behavior appears to result from interactions between NE-βCp droplets and HA chains, which may disrupt the jet and hinder solvent

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• mechanism occurs from nano- or microsized droplets or solid fragments directly ejected from the target. The dominating mechanism of NP formation depends on the laser parameters, mainly laser pulse duration and laser fluence. For the nanosecond laser pulse of high energy density (in the range 108–1010 W·cm−2

• ), the thermal evaporation is preferential [1], while for picosecond and femtosecond laser pulses of lower power density, the explosive ejection mechanism typically prevails resulting in NP formation at earlier stages from the ejected droplets or fragments. 1.3 Nanoparticle nucleation and growth After

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• release, and protection against degradation. Nanoemulsions are colloidal systems with droplets of 20 to 500 nm, which improve the dispersion of the compounds, protect their active properties, and enhance their efficacy. This review addresses the potential of nanoemulsions as efficient carriers of EOs, and

• ]. Beyond liposomes, other lipid-based nanosystems have gained prominence, such as nanoemulsions (NEs) [87]. NEs are kinetically stable dispersed systems composed of two immiscible phases, typically an oil and aqueous phases, with droplets (20–500 nm) stabilized by surfactants. NEs can be classified as oil

• , myristicin, γ-terpinene, and thymol methyl ether. The nanoemulsion was prepared using a low-energy method, combining 5% of essential oil, 5% of polysorbate 20, and 90% of water. The most stable formulation was obtained with a 1:3 ratio between oil and surfactant, presenting droplets with a diameter between

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• formulation parameters – such as drug miscibility with the oil phase, droplet size, and size uniformity – have been directly correlated with permeation efficiency across the skin barrier [32][33]. Specifically, the encapsulation of lipophilic compounds like phytol in finely dispersed droplets within oil-in

• -water (O/W) nanoemulsions is more effective when the droplets are spherical and have diameters close to 200 nm. This enhanced effect has been attributed to increased Laplace pressure, which refers to the pressure difference between the interior and exterior of a curved interface, and leads to higher

• evaluated over a 30-day period by monitoring droplet size, PdI, ZP, and pH using the same methodologies previously described. Morphology The morphology of the nanoemulsion droplets was examined by transmission electron microscopy using a FEI Tecnai G2 Spirit Biotwin microscope operating at 120 kV (FEI

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• ingredient [1]. NEs are designed as droplets that can potentially replenish the lipid layer in DED patients, mimicking the trilayered structure of the tear film, consisting of lipid, aqueous, and mucin layers [13][15][18][20]. According to the literature, the tear film compromises the stability of NE

• pore size) and stored at room temperature. The hydrophilic nature of PES facilitates filtration of lipid-based nanoemulsions, while potential retention of larger or deformable droplets may occur without compromising overall stability. Surfactant concentration in the pre-formulations Pre-nanoemulsions

• , water, and surfactant/co-surfactant are ideal for the formation of nanometer-sized droplets, minimizing the risk of coalescence or phase separation. A viable strategy to streamline the extensive series of formulations and to locate the optimized region in the ternary diagram involves diluting an

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• particles as the resulting droplets are quenched by the surrounding liquid. This process is influenced by the size-dependent optical absorption efficiency and heat capacity of the NPs [43][44]. Utilizing this method, submicrometer spherical particles can be fabricated from a variety of materials, including

• technique creates uniform coatings on a substrate by directing an atomized stream of molten material droplets onto it [140]. A schematic representation of an ultrasonic spray deposition setup is provided in Figure 13. The thickness of the film is mainly determined by factors such as the distance between the

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• phenomenon that becomes increasingly efficient at elevated temperatures, promoting the formation of smaller droplets. Additionally, elevated temperatures enhance molecular mobility and solubility, facilitating droplet disruption and dispersion effects observed in bocaiúva oil nanoemulsions above 60 °C [48

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• the mixing region where the ablated matter interpenetrates the solvent vapor. In that region, the nanoparticle droplets stemming from the plume cool fast and solidify first [50]. Consequently, the carbon species will have more time to interact with the plume and diffuse more significantly into the

• ., graphitic carbon shells) (Figure 5 (3) and (4)). In contrast, during ns-LAL, the conditions of TL are present for a longer time and thereby the plume and alloy droplets are expected to stay in these conditions for approximately 15 ns (pulse duration of 10 ns and additional heated period [64]). Consequently

• while the temperature is only around twice as high. Consequently, we can expect that the MSD is even lower for ps-LAL, possibly falling in a sub-nanometer range, which makes diffusion into liquid metal droplets more unlikely. This hypothesized mechanism that takes carbon diffusion into the particle core

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

Synthesis and magnetic transitions of rare-earth-free Fe–Mn–Ni–Si-based compositionally complex alloys at bulk and nanoscale

• Shabbir Tahir,
• Tatiana Smoliarova,
• Carlos Doñate-Buendía,
• Michael Farle,
• Natalia Shkodich and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 823–836, doi:10.3762/bjnano.16.62

• region of the target decomposes into vapor, small clusters, and droplets, and large particles result from photomechanical spallation, leading to the ejection of larger droplets. The average particle size of the Al alloy NPs (xc = 18.4 ± 15.5 nm) is larger than that of Ge-based CCA NPs (xc = 13.4 ± 9.1 nm

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• known that microemulsions promote greater bioavailability of hydrophobic molecules orally due to the nanometric size of the droplets. Additionally, nonionic surfactants such as Tween® and Cremophor® inhibit CYP3A metabolism or P-glycoprotein drug efflux, thus improving intestinal drug absorption. Thus

• containing 10% EOCF were then prepared individually (Table 1), and the dispersions were evaluated macroscopically and characterized 48 h after they were obtained. Physicochemical characterization of the selected microemulsions The polydispersity index and average hydrodynamic radius of the droplets were

Size control of nanoparticles synthesized by pulsed laser ablation in liquids using donut-shaped beams

• Abdel Rahman Altakroury,
• Oleksandr Gatsa,
• Farbod Riahi,
• Zongwen Fu,
• Miroslava Flimelová,
• Andrei Samokhvalov,
• Stephan Barcikowski,
• Carlos Doñate-Buendía,
• Alexander V. Bulgakov and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 407–417, doi:10.3762/bjnano.16.31

• . In contrast, ablation with a Gaussian beam results in the ejection of molten droplets from the overheated central region and the formation of a crater rim. For instance, it has been demonstrated that during vortex-beam ultrashort laser ablation of thin metal films [55] and tungsten targets in air [56

Bioinspired nanofilament coatings for scale reduction on steel

• Siad Dahir Ali,
• Mette Heidemann Rasmussen,
• Jacopo Catalano,
• Christian Husum Frederiksen and
• Tobias Weidner

Beilstein J. Nanotechnol. 2025, 16, 25–34, doi:10.3762/bjnano.16.3

• protrusions that have an overhanging shape and low surface energy can effectively render a surface super-hydrophobic (Figure 1D,F). This texture creates an energy barrier, causing water droplets to rest on the protrusions while trapping air beneath them. In analogy with the texture of Collembola skin, this

• agreement with what has been reported before for super-hydrophobic SNF coatings on polymers [18], glass [23], and textiles [16]. Since the water contact is well above 150° and droplets are highly mobile (please see the videos in the Supporting Information File 1–3) – the definition of super-hydrophobicity

• using an FTA1000 contact angle system (First Ten Angstroms, Inc.) at ambient temperature. The volume of the water droplets was 2.5–3.0 µL. Autoclave stability and decompression/explosion tests The autoclave (Parr series 5521) is based on a 300 mL vessel and reactor controller (4848, Parr). A home-build

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• microfluidics and high-shear-force homogenization [110]. As DDS, nanoemulsions can be reservoirs for encapsulating hydrophobic substances [111]. Moreover, emulsions of emulsions or double emulsions can be prepared by dispersing the droplets of primary emulsion into another liquid phase. Double emulsions can be

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• surface energy values in the following order: [51]. At temperature and saturated vapour pressure values suitable for referential growth directions, ZnO crystals develop from Zn droplets working as nuclei/seeds, which react with oxygen in order to develop characteristic nanostructures. Following

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• measurements were conducted with the sessile drop method. Droplets of 5 µL were pipetted onto the surface, and an image was captured. Eight images from two duplicates of each sample type were acquired on a smartphone device and processed in ImageJ (NIH). Atomic force microscopy AFM was conducted on a Veeco di

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• with water. The expanding metal/water mixture promotes rapid nucleation and growth of small metal NPs and contributes to forming a cavitation bubble. The hot metal layer also breaks into larger droplets due to instabilities, creating NPs of different sizes within a few nanoseconds of laser exposure [6

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• high, beaded nanofibers and many other defects are formed mainly because of more unspun droplets as a result of larger droplet volume and increased bending instabilities [56][58]. Needle tip-to-collector distance Since the distance between needle tip and collector influences the amount of evaporated

Functional fibrillar interfaces: Biological hair as inspiration across scales

• Guillermo J. Amador,
• Brett Klaassen van Oorschot,
• Caiying Liao,
• Jianing Wu and
• Da Wei

Beilstein J. Nanotechnol. 2024, 15, 664–677, doi:10.3762/bjnano.15.55

• microscopic pillars. The superhydrophobic surface is self-cleaning since water droplets bead up on the surface, and, when they roll off, they pick up any dirt or other particles and remove them from the leaf’s surface. This phenomenon was termed the “Lotus effect” and has been translated to the development of

Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• but mostly contains water-soluble and lipid-soluble substances [31][32][33][34][35] creating lipid droplets in an aqueous fluid [27][36] or hydrophilic nanodroplets embedded in an oily continuous phase [23][37]. Additionally, the tarsal secretion could be a mixture of multiple substances that are

• , especially in Phasmatodea. Recent investigations of the ultrastructure and material properties of the smooth tarsal attachment pads of phasmids complement our information on the morphology of the droplets [38], biomechanics of their attachment performance [28][46][47][48][49][50][51], and the complementarity

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• volatility, make their formulation a true challenge. In this regard, nanoemulsions (NEs), which are dispersions of two immiscible liquids with one of them dispersed as small droplets [11][12], stand out as new delivery vehicles for these bioactive compounds. They are especially important to enhance the water

• , leading to the generation of dispersed material on a nanoscale [15]. The low-energy methods are characterized by the use and control of the chemical energy of the system in the formation of droplets on the nanoscale. A crucial point is that these systems can be obtained at low cost and with eco-friendly

• maturation, a very important mechanism when it comes to the instability of NEs. It is related to the difference between the droplet sizes in the formulation, with the smaller droplets having greater chemical potential and, thus, diffusing to the larger ones [26]. Formulations with HLB values of 14 and 15

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• concentration for further experiments. During the freeze-drying process, BSA/PDA NPs acted as surfactant and were located around water droplets when the water was rapidly sublimated, which resulted in the formation of a foam (Supporting Information File 1, Figure S1a). After freeze-drying, the foam could be

Spatial variations of conductivity of self-assembled monolayers of dodecanethiol on Au/mica and Au/Si substrates

• Julian Skolaut,
• Jędrzej Tepper,
• Federica Galli,
• Wulf Wulfhekel and
• Jan M. van Ruitenbeek

Beilstein J. Nanotechnol. 2023, 14, 1169–1177, doi:10.3762/bjnano.14.97

• . This was avoided in later experiments by using eutectic GaIn (eGaIn) droplets [8][9][10][11]. These are much more viscous, to the point that they are almost solid. This reduces the amount of leak currents significantly and makes studies on the conductivity of SAMs much more reliable. A more widely

• characteristics. Moreover, the probes used in CAFM are significantly sharper compared to, for example, mercury droplets or eGaIn, which makes it possible to avoid short circuits to the metallic surface relatively easily. In previous studies, CAFM has been used to investigate the conductivity of surfaces and SAMs