Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

• Magdalena Lasak and
• Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

• Magdalena Lasak Karol Ciepluch Division of Medical Biology, Jan Kochanowski University in Kielce, Uniwersytecka Street 7, Kielce, Poland 10.3762/bjnano.14.28 Abstract Nanoparticles (NPs) exhibit unique physicochemical properties that enable them to overcome biological barriers and to be

• important permeability barrier for NPs, which is of key importance for their medical applications [5][14]. The ability of NPs to cross the endothelial monolayer depends on both the physicochemical properties of the NPs and the biology and physiology of the vessels themselves [20]. Understanding the

• proteins, is determined by the stability, biocompatibility, and solubility of such conjugates, which in turn opens up new perspectives in medical applications [16][42]. Nanotheranostic applications use NPs for diagnostic and therapeutic purposes for serious metabolic, cancer, and neurodegenerative diseases

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• Qixiong Lin Yueyou Peng Yanyan Wen Xiaoqiong Li Donglian Du Weibin Dai Wei Tian Yanfeng Meng The Ninth Clinical Medical School of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China School

• of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China Department of General Surgery, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 030024, China 10.3762/bjnano.14.24 Abstract Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic

• various medical fields, such as cardiovascular diseases, neurological diseases, malignant neoplasm, orthopedic diseases, and immune system diseases, providing a new approach to various treatment problems [3]. These nanoformulations provide advantages over conventional pharmaceutical formulations in terms

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• green light, and the reverse cis-to-trans isomerization occurs under blue light [50]. Compared with UV light, visible light is advantageous for medical applications, since it can penetrate more deeply into tissues and causes less photodamage to healthy cells. In the same way as unsubstituted azobenzene

• recent topics on medical applications of CyD 6.1 Chemical modification of CyD for precise targeting to predetermined cells A multicharged nanoassembly was constructed from β-CyD bearing seven hexylimidazolium units, adamantane-grafted hyaluronic acid, and chlorambucil (an anticancer drug) [90]. In cancer

Concentration-dependent photothermal conversion efficiency of gold nanoparticles under near-infrared laser and broadband irradiation

• Vikas,
• Raj Kumar and
• Sanjeev Soni

Beilstein J. Nanotechnol. 2023, 14, 205–217, doi:10.3762/bjnano.14.20

• data. Acknowledgements The authors acknowledge CSIR-Central Scientific Instruments Organisation, Chandigarh, India, for infrastructure support. Funding Vikas gratefully acknowledges the fellowship from Indian Council of Medical Research, Delhi, India via grant number #5/3/8/83/ITR-F/2020-ITR.

Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine

• Zoran M. Marković,
• Milica D. Budimir,
• Martin Danko,
• Dušan D. Milivojević,
• Pavel Kubat,
• Danica Z. Zmejkoski,
• Vladimir B. Pavlović,
• Marija M. Mojsin,
• Milena J. Stevanović and
• Biljana M. Todorović Marković

Beilstein J. Nanotechnol. 2023, 14, 165–174, doi:10.3762/bjnano.14.17

• synthesis by a solvothermal method. The prepared CQDs were encapsulated into medical grade polyurethane (PU) films by a swelling–encapsulation–shrink method. It was investigated how the precursor influenced the structure (morphology and chemical composition) and further prooxidative, antibacterial, and

• 12 h at 180 °C. All chemicals were purchased and used as received. After synthesis, CQDs were filtered through polytetrafluoroethylene (PTFE) filters with 100 nm pore size. The prepared hydrophobic CQDs (toluene solution, 20 mL) were encapsulated into medical grade polyurethane (PU) films (dimension

Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating

• Jessica Plé,
• Marine Dabert,
• Helene Lecoq,
• Sophie Hellé,
• Lydie Ploux and
• Lavinia Balan

Beilstein J. Nanotechnol. 2023, 14, 95–109, doi:10.3762/bjnano.14.11

• Biomédecine de Strasbourg, F-67000 Strasbourg, France Université de Strasbourg, Faculté Dentaire, F-67000 Strasbourg, France CNRS, F-67000 Strasbourg, France 10.3762/bjnano.14.11 Abstract The control of microbial proliferation is a constant battle, especially in the medical field where surfaces, equipment

Single-step extraction of small-diameter single-walled carbon nanotubes in the presence of riboflavin

• Polina M. Kalachikova,
• Anastasia E. Goldt,
• Eldar M. Khabushev,
• Timofei V. Eremin,
• Timofei S. Zatsepin,
• Elena D. Obraztsova,
• Konstantin V. Larionov,
• Liubov Yu. Antipina,
• Pavel B. Sorokin and
• Albert G. Nasibulin

Beilstein J. Nanotechnol. 2022, 13, 1564–1571, doi:10.3762/bjnano.13.130

• by the same ultrasonication protocol. Single-step gel extraction protocol A single-step gel extraction procedure was developed based on the size-exclusive gel chromatography method published elsewhere [22]. Medical syringes (20 mL, 10 cm in length, and 1.5 cm in inner diameter) were used as the

Frequency-dependent nanomechanical profiling for medical diagnosis

• Santiago D. Solares and
• Alexander X. Cartagena-Rivera

Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122

• healthcare strategies that link routine AFM measurements with computer analysis, real-time communication with healthcare providers, and medical databases. This approach would be appropriate for diseases such as cancer, lupus, arteriosclerosis and arthritis, among others, which bring about significant

• mechanical changes in the affected tissues. Keywords: atomic force microscopy; healthcare; mechanical properties; mechanobiology; medical diagnosis; Introduction Since its invention in the early 1980s, atomic force microscopy (AFM) has been extensively used for topographical, mechanical, electrical, and

• -time communication with healthcare providers, as well as the development of large databases of robust measurements classified by patient biometrics or as a function of disease progress. Perspective Limited adoption of nanomechanical AFM measurements in broad-impact medical applications AFM is a well

Density of states in the presence of spin-dependent scattering in SF bilayers: a numerical and analytical approach

• Tairzhan Karabassov,
• Valeriia D. Pashkovskaia,
• Nikita A. Parkhomenko,
• Anastasia V. Guravova,
• Elena A. Kazakova,
• Boris G. Lvov,
• Alexander A. Golubov and
• Andrey S. Vasenko

Beilstein J. Nanotechnol. 2022, 13, 1418–1431, doi:10.3762/bjnano.13.117

• Tairzhan Karabassov Valeriia D. Pashkovskaia Nikita A. Parkhomenko Anastasia V. Guravova Elena A. Kazakova Boris G. Lvov Alexander A. Golubov Andrey S. Vasenko HSE University, 101000 Moscow, Russia Sechenov First Moscow State Medical University, 119991 Moscow, Russia Faculty of Science and

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• is no need for a medical facility or health professional for each dose. It is less stressful and more affordable for the patient [16]. Considering that cancer is a chronic disease and that the person needs long-term treatment, oral formulations for cancer chemotherapy are still an issue of interest

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• , antileishmanial drugs which are currently available on the market showed several drawbacks including irreversible toxic effects, high costs, prolonged treatment, need for adequate medical care, emergence of drug resistance, and parenteral administration [20][21]. Recently, nanoantimicrobials based on biogenic

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• nanotubes and functional nanomaterials, will significantly improve the performance of probes and further promote the broader and deeper application of SPM. It will significantly impact society in life science, drug discovery, and medical diagnosis. Sharpening of a blunt tip and study of its stability after

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• medical applications. Conclusion Quartz crystal microbalance provides one of the most versatile sensing technologies due to its low cost, rapid response, high sensitivity, easy operation, and real-time detection in contrast to conventional

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• Piotr Gadzinski Anna Froelich Monika Wojtylko Antoni Bialek Julia Krysztofiak Tomasz Osmalek Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences Student Research Group of Pharmaceutical Technology, Poznan University of Medical Sciences 10.3762/bjnano.13.98

• preparations, the most commonly used are eye drops [49][50][51], ointments [52][53], or gels [54][55], containing the drug in a dissolved or suspended form [56][57]. They are applied by medical personnel or by the patient himself to the surface of the eye, to the conjunctival sac, or on the eyelid. Their main

• /). Microscopic image of the MNs obtained by Amer and Chen. Figure 6 was adapted from [178], M. Amer; R. K. Chen, "Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery", Journal of Engineering and Science in Medical Diagnostics and Therapy, with permission from ASME. Copyright

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• photobleaching), and efficient photoluminescence. CDs have a broad spectrum of applications in the analytical, medical, biotechnology, biology, and theranostics domains [3][4]. The typical photoluminescence yield of CDs is less than 10%. Surface-passivating chemicals are used to improve the photoluminescence

• , wheat straw, and rice straw by Ding et al. These CDs were utilized to detect Fe3+, which could be useful in areas of environmental remediation and medical diagnosis [77]. A hydrothermal technique employing near-critical water has been utilized recently to develop a simple, cost-effective, and

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• , Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, College of Dental Medicine, Qatar University, Doha, Qatar Department of Bionano Engineering, Center for Bionano

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• biomaterials and medical devices with antifouling and antibacterial properties, but with reduced susceptibility to enzymatic degradation [85]. General advantages of AMPs/HDPs and mimicking polymer systems over antibiotics as a new generation of antimicrobial agents are their functional diversity, broad

• possess AMP-like antimicrobial activities. It is produced in the silk gland, but also to a lesser extent in the midgut and fat body [117]. As a consequence of its immunogenic and allergic properties, the sericin coating of silkworm silk fibres has to be removed before further processing or use in medical

Design and selection of peptides to block the SARS-CoV-2 receptor binding domain by molecular docking

• Kendra Ramirez-Acosta,
• Ivan A. Rosales-Fuerte,
• J. Eduardo Perez-Sanchez,
• Alfredo Nuñez-Rivera,
• Josue Juarez and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2022, 13, 699–711, doi:10.3762/bjnano.13.62

• peptides to neutralize the infective mechanism of SARS-CoV-2 through the RBD is an interesting strategy. The binding ability of 104 peptides (University of Nebraska Medical Center’s Antimicrobial Peptide Database) to the RBD was assessed using molecular docking. Based on the molecular docking results

• was used to perform molecular docking of 104 biological peptides, selected from the University of Nebraska Medical Center’s Antimicrobial Peptide Database (APD) [22][23][24], and theoretical peptides with the region of the SARS-CoV-2 RBD that binds to the cellular receptor ACE2 (called the RBD active

• application of SARS-CoV-2 vaccines [26][27]. Furthermore, the proposed peptides may elude the immune system and bind effectively to SARS-CoV-2 RBD. Materials and Methods Ligand selection for screening In total, 104 peptides were chosen from the University of Nebraska Medical Center’s Antimicrobial Peptide

Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• considerable potential for medical applications such as transdermal drug delivery, point-of-care diagnostics, and vaccination. These miniature microdevices should successfully pierce the skin tissues while having enough stiffness to withstand the forces imposed by penetration. Developing low-cost and simple

• bacterial infections and medical emergencies, with point-of-care patch diagnostics replacing ponderous and expensive laboratory testing. Therefore, there is a growing interest in small patches incorporating mass manufacturable polymer MNs [4][5], with the point-of-care rapid diagnosis market alone predicted

• classified into solid, hollow, coated, hydrogel-forming, and dissolvable types, which depending on the specific medical applications [12][13], are fabricated using silicon, metal, ceramic, silica glass, carbohydrate, and polymers [7][14]. In recent years, polymeric MNs have gained a lot of interest due to

A new method for obtaining the magnetic shape anisotropy directly from electron tomography images

• Cristian Radu,
• Ioana D. Vlaicu and
• Andrei C. Kuncser

Beilstein J. Nanotechnol. 2022, 13, 590–598, doi:10.3762/bjnano.13.51

• very brief review of such techniques is given in the following. The particle size and shape of particulate systems ranging from the nanometer (characteristic to catalysis, sensoristics, spintronics, and some medical therapies [1][2][3]) over the micrometer (pharmaceutical industry and powder metallurgy

• advancements in medical fields (hyperthermia and drug delivery), permanent magnet industry, sensoristics, and spintronics. The program has been tested not only on simulated tomograms but also on tomograms obtained on real-life systems of magnetite MNPs, obtained in-house by co-precipitation methods. Starting

Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles

• Gufeng Li,
• Shaoqing Li,
• Rui Wang,
• Min Yang,
• Lizhu Zhang,
• Yanli Zhang,
• Wenrong Yang and
• Hongbin Wang

Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46

• the reduced form were purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. 2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid (HEPES) was purchased from Shanghai Mackin Biochemical Co., Ltd. Cervix carcinoma (HeLa cells) were purchased from Kunming Medical University. All reagents

Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review

• Ioana Marica,
• Fran Nekvapil,
• Maria Ștefan,
• Cosmin Farcău and
• Alexandra Falamaș

Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40

• , due to the energy and electron transfer from plasmon-resonant metal surfaces to the adjacent semiconductor. Such hybrid materials have been proposed for medical and pharmaceutical applications, catalysis, and electronics [88]. The photoluminescence emission of ZnO nanoparticles has been exploited in

Electrostatic pull-in application in flexible devices: A review

• Teng Cai,
• Yuming Fang,
• Yingli Fang,
• Ruozhou Li,
• Ying Yu and
• Mingyang Huang

Beilstein J. Nanotechnol. 2022, 13, 390–403, doi:10.3762/bjnano.13.32

• switch, thus reducing the need for external excitation. Ultrasonic transducers based on capacitive switch structures are widely used in medical imaging, underwater tests, and obstacle detection. Saadatmand and Kook [97] conducted a theoretical analysis on electrostatically driven ultrasonic transducers

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• Zahra Nabizadeh Mahmoud Nasrollahzadeh Hamed Daemi Mohamadreza Baghaban Eslaminejad Ali Akbar Shabani Mehdi Dadashpour Majid Mirmohammadkhani Davood Nasrabadi Department of Medical Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran Biotechnology Research Center

• , Semnan University of Medical Sciences, Semnan, Iran Department of Chemistry, Faculty of Science, University of Qom, Qom 37185-359, Iran Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Department of Stem Cell and

• Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Department of Epidemiology and Biostatistics, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran 10.3762/bjnano.13.31 Abstract Osteoarthritis, which typically

The effect of metal surface nanomorphology on the output performance of a TENG

• Yiru Wang,
• Xin Zhao,
• Yang Liu and
• Wenjun Zhou

Beilstein J. Nanotechnol. 2022, 13, 298–312, doi:10.3762/bjnano.13.25

• [18][19][20][21], water wave energy [22][23], acoustic energy [24][25], and energy generated by human activities [26][27] can be collected and effectively converted into electrical energy for medical, meteorological, and other applications. A new type of TENG with environmental protection, high