Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• Taramelli 12, 27100, Pavia, Italy Department of Physics, University of Milano-Bicocca, piazza dell’Ateneo Nuovo, 20126, Milan, Italy 10.3762/bjnano.11.98 Abstract Bacterial contamination is a severe issue that affects medical devices, hospital tools and surfaces. When microorganisms adhere to a surface

• (e.g., medical devices or implants) they can develop into a biofilm, thereby becoming more resistant to conventional biocides and disinfectants. Nanoparticles can be used as an antibacterial agent in medical instruments or as a protective coating in implantable devices. In particular, attention is

• application of such materials in treating infections and eliminating biofilms that are formed at the surface of indwelling medical devices. Even though promising for clinical application, this approach needs to be intensively investigated through preclinical studies and clinical trials. Pie chart showing the

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• , 400006, Romania Electron Microscopy Integrated Laboratory, National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Str., Cluj-Napoca, Cluj County, 400293, Romania Functional Sciences Department, Medical Faculty, University of Medicine and Pharmacy “Victor

• .11.94 Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter

• therapeutic efficacy, and safety studies. Keywords: drug delivery; drug targeting; endocytosis; medical; nanoparticles; superparamagnetic iron oxide nanoparticles (SPIONs); toxicity; Introduction Nanoencapsulation technologies have been researched over the past several decades and have been widely

Vibration analysis and pull-in instability behavior in a multiwalled piezoelectric nanosensor with fluid flow conveyance

• Sayyid H. Hashemi Kachapi

Beilstein J. Nanotechnol. 2020, 11, 1072–1081, doi:10.3762/bjnano.11.92

• , pharmaceutical, agricultural, environmental, advanced materials, chemical science, physics, electronics, information technology, biomedical and medical fields [1][2][3][4][5][6][7][8][9][10]. Due to this extended use of nanosensors, especially piezoelectric nanosensors in vibration devices, mathematical models

A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans

• Selene Acosta,
• Carlos Moreno-Aguilar,
• Dania Hernández-Sánchez,
• Beatriz Morales-Cruzado,
• Erick Sarmiento-Gomez,
• Carla Bittencourt,
• Luis Octavio Sánchez-Vargas and
• Mildred Quintana

Beilstein J. Nanotechnol. 2020, 11, 1054–1061, doi:10.3762/bjnano.11.90

• prevailing drugs used to fight fungal infections usually require long treatments and very often present side effects [2]. For these reasons, improved antifungal therapies must be developed to treat fungal infections [4]. An alternative approach, used as medical technology to treat diseases like cancer and

• against C. albicans. Candida albicans is the most virulent Candida specie with a high economic and medical relevance due to high health care cost, in addition to high morbidity and mortality rates, especially in immunocompromised patients [30]. As a result, C. albicans is commonly used to test different

• of new ways of applying PDT. More studies must be done in order to determine the toxicity of this new generation of nanostructured photosensitizers, such as the hybrid nanomaterial presented in this work. However, immediate applications of the hybrid nanomaterial, for example, the coating of medical

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• Department of MRI, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China Institute of Biomedical Engineering, Shanxi Key Laboratory of Materials Strength & Structural Impact, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China 10.3762/bjnano.11.84 Abstract The

• collected with an inverted phase-contrast microscope (Nikon, TiS, Japan). In vivo magnetic resonance imaging All the animal experiments were performed in compliance with the guidelines for animal experimentation from the Shanxi Medical University. MRI was performed in three Sprague Dawley (SD) rats that

A 3D-polyphenylalanine network inside porous alumina: Synthesis and characterization of an inorganic–organic composite membrane

• Jonathan Stott and
• Jörg J. Schneider

Beilstein J. Nanotechnol. 2020, 11, 938–951, doi:10.3762/bjnano.11.78

• many fields such as membrane separation [1][2][3][4][5] or adsorbent materials [1][6][7][8]. The combination of inorganic porous supports (such as alumina and a variety of synthetic polypeptides) that can be grafted onto such surfaces is also promising, especially with respect to medical and analytical

• -gels of such composite membranes can be further improved with regard to adsorption materials in medical and analytical applications or analytical separation processes. Results and Discussion Inorganic porous membranes of sintered corundum particles (ALOX-membranes) were used as substrates for polymer

• regard, the optimal conditions for effective use in reversed-phase solid phase extraction have to be further adjusted in future investigations. Conclusion This study demonstrates the synthesis of inorganic–organic composite membranes, which may be useful as adsorption materials in medical and analytical

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• life expectancy worldwide. Moreover, there is still a large number of unmet medical needs concerning the treatment of most central nervous system (CNS) diseases, as it is the case for stroke where treatments are limited to brain reperfusion. No treatments are available to recover the brain areas

• . Drugs can be transported to the brain via the olfactory bulb, located at the top of the nasal cavity. C) Systemic delivery. Drugs can reach the brain by crossing the blood–brain barrier (BBB) around the brain capillaries. Made using cliparts from Servier Medical Art by Servier, https://smart.servier.com

• /. Original cliparts are licensed under a Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/. Physiological pathways through the BBB. Inspired by [3]. Made using cliparts from Servier Medical Art by Servier, https://smart.servier.com/. Original cliparts are

A novel dry-blending method to reduce the coefficient of thermal expansion of polymer templates for OTFT electrodes

• Xiangdong Ye,
• Bo Tian,
• Yuxuan Guo,
• Fan Fan and
• Anjiang Cai

Beilstein J. Nanotechnol. 2020, 11, 671–677, doi:10.3762/bjnano.11.53

• -generation large-area, light-weight, flexible, and stretchable optoelectronic applications [1][2], including flexible displays [3], electronic papers [4], sensors [5], and medical applications [6]. Fabricating high-performance OTFTs usually requires that the electrodes on the polymer template are precisely

• of flexible displays, electronic papers, sensors, and medical applications, and provide new solutions for constructing large-area, light-weight, flexible, and stretchable optoelectronic applications. The experimental procedure for preparation of the PDMS/SiO2 composite template via dry blending: (a

Examination of the relationship between viscoelastic properties and the invasion of ovarian cancer cells by atomic force microscopy

• Mengdan Chen,
• Jinshu Zeng,
• Weiwei Ruan,
• Zhenghong Zhang,
• Yuhua Wang,
• Shusen Xie,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2020, 11, 568–582, doi:10.3762/bjnano.11.45

• , China Department of Ultrasound Medical, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China Fujian Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China 10.3762/bjnano.11.45 Abstract

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• targeted drug delivery, active pharmaceutical carriers and medical imaging. However, poor knowledge of the side effects related to their use is an obstacle to clinical translation. For the development of molecular drugs, the concept of safe-by-design has become an efficient pharmaceutical strategy with the

• to take into consideration for those materials that are intended for medical applications. The formation of nanoparticle agglomerates can cause severe side effects that may induce occlusion of blood vessels and thrombotic events. Additionally, nanoparticles can interfere with the coagulation cascade

• nanomaterials are among the most studied inorganic materials for medical applications due to their promising properties. However, some studies have shown that they are both capable of inducing the formation of thrombi, and the relevant mechanisms of action are still under debate [9]. In fact, single-walled

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India 10.3762/bjnano.11.41 Abstract Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine

Evolution of Ag nanostructures created from thin films: UV–vis absorption and its theoretical predictions

• Robert Kozioł,
• Marcin Łapiński,
• Paweł Syty,
• Damian Koszelow,
• Wojciech Sadowski,
• Józef E. Sienkiewicz and
• Barbara Kościelska

Beilstein J. Nanotechnol. 2020, 11, 494–507, doi:10.3762/bjnano.11.40

• : dewetting; finite-difference time-domain (FDTD) method; plasmon resonance; silver (Ag) nanostructures; thin films; UV–vis absorption; Introduction In the last decade there has been significant development in sensor-related research regarding the application in optical, medical or biological areas [1][2][3

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), Institutsky per. 9, Dolgoprudnyi, Moscow Region, 141701, Russia 10.3762/bjnano.11.39 Abstract A number of bacterial glycans are specific markers for the detection and the

Nanoparticles based on the zwitterionic pillar[5]arene and Ag⁺: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549

• Dmitriy N. Shurpik,
• Denis A. Sevastyanov,
• Pavel V. Zelenikhin,
• Pavel L. Padnya,
• Vladimir G. Evtugyn,
• Yuriy N. Osin and
• Ivan I. Stoikov

Beilstein J. Nanotechnol. 2020, 11, 421–431, doi:10.3762/bjnano.11.33

• thousands of years, the use of this metal has grown into an entire industry [1]. A separate area of this industry is the use of silver nanoparticles (AgNPs), which are the source of Ag+ ions in many commercial products, such as food packaging, odor-resistant fabrics, household appliances and medical devices

Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels

• Armel Boutchuen,
• Dell Zimmerman,
• Abdollah Arabshahi,
• John Melnyczuk and
• Soubantika Palchoudhury

Beilstein J. Nanotechnol. 2020, 11, 296–309, doi:10.3762/bjnano.11.22

• , United States Department of Chemistry, Clark Atlanta University, Georgia 30314, United States 10.3762/bjnano.11.22 Abstract Nanoparticles (NPs) are considered as one of the most promising drug delivery vehicles and a next-generation solution for current medical challenges. In this context, variables

• ; Introduction Current research increasingly highlight the importance of drug delivery systems in engineering new solutions to our medical challenges [1][2][3]. A drug delivery agent should be biocompatible, easily administered to the patient, and capable of carrying the drug to the disease site before

• enhanced circulation and controlled delivery to the disease sites compared to conventional drug formulations. In the context of achieving next-generation medical solutions with NPs, an in vitro technique that can mimic or visualize the transport of these NP-based drugs through vascular networks will be a

Anomalous current–voltage characteristics of SFIFS Josephson junctions with weak ferromagnetic interlayers

• Tairzhan Karabassov,
• Anastasia V. Guravova,
• Aleksei Yu. Kuzin,
• Elena A. Kazakova,
• Shiro Kawabata,
• Boris G. Lvov and
• Andrey S. Vasenko

Beilstein J. Nanotechnol. 2020, 11, 252–262, doi:10.3762/bjnano.11.19

• , Moscow State Pedagogical University, 119992 Moscow, Russia Sechenov First Moscow State Medical University, 119991 Moscow, Russia National Institute of Advanced Industrial Science and Technology,1-1-1 Umezono, Tsukuba, Ibaraki 305-8563, Japan I.E. Tamm Department of Theoretical Physics, P.N. Lebedev

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• medical research [7]. Compared to the other translocation techniques mentioned, CPPs are capable of entering the cells in a noninvasive manner, they do not destroy the integrity of the cellular membranes and are considered highly efficient and safe. Thus, they provide new avenues for research and

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

• Dávid Juriga,
• Evelin Sipos,
• Orsolya Hegedűs,
• Gábor Varga,
• Miklós Zrínyi,
• Krisztina S. Nagy and
• Angéla Jedlovszky-Hajdú

Beilstein J. Nanotechnol. 2019, 10, 2579–2593, doi:10.3762/bjnano.10.249

• (amino acid); poly(aspartic acid); polymer; Introduction The number of medical applications of polymer hydrogels increased substantially during the last decades due to their similarity to soft tissues [1][2][3]. Polymer hydrogels possess properties of solid materials such as deformability and rigidity

• well as biocompatibility and biodegradability are also fundamental features of polymers developed for numerous medical applications [11][12]. Polymer hydrogels are capable of releasing physically entrapped drug molecules. The release kinetics of the loaded drug molecules depend significantly on the

• ]. In the last decades, the interest of scientists in PASP-based hydrogels increased significantly due to their potential applications in medical, pharmaceutical and environmental fields [25][34][41][42][43][44]. Several publications can be found concerning different types of cross-linkers to prepare

Frontiers in pharmaceutical nanotechnology

• Matthias G. Wacker

Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244

• materials with a long history of medical use [12]. Pharmaceutical nanotechnology is not limited to translational research but, after many years of trial and error, we have to accept that reliable pharmacological and toxicological effects are a key element of industrial formulation development. Understanding

Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

• Jingran Zhang,
• Tianqi Jia,
• Yongda Yan,
• Li Wang,
• Peng Miao,
• Yimin Han,
• Xinming Zhang,
• Guangfeng Shi,
• Yanquan Geng,
• Zhankun Weng,
• Daniel Laipple and
• Zuobin Wang

Beilstein J. Nanotechnol. 2019, 10, 2483–2496, doi:10.3762/bjnano.10.239

• Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150010, P.R. China 5Department of Gynaecology, No. 3 Subsidiary Hospital, Harbin Medical University, Harbin, Heilongjiang, 150040, P.R. China 10.3762/bjnano.10.239 Abstract Nanostructures have been widely employed in

Atomic force acoustic microscopy reveals the influence of substrate stiffness and topography on cell behavior

• Yan Liu,
• Li Li,
• Xing Chen,
• Ying Wang,
• Meng-Nan Liu,
• Jin Yan,
• Liang Cao,
• Lu Wang and
• Zuo-Bin Wang

Beilstein J. Nanotechnol. 2019, 10, 2329–2337, doi:10.3762/bjnano.10.223

• Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China Computer Department, Changchun Medical College, Changchun 130031, China JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK 10.3762/bjnano.10.223 Abstract The stiffness and the topography of the substrate at

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

• Nikolai A. Usov,
• Ruslan A. Rytov and
• Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

• (AMF) of frequency f = 100–500 kHz and amplitude H0 = 100–200 Oe. This would allow the tumor temperature to be maintained at about 42 °C if a magnetic nanoparticle assembly were capable to absorb efficiently the energy of the alternating magnetic field. According to a number of medical indications [1

• frequencies and amplitudes is recommended for medical reasons to be used in magnetic hyperthermia [49][50]. In the first mode existing in domain I in Figure 2 at low and moderate RMF frequencies the vectors and rotate in unison around the Z-axis with the RMF frequency. However, there are constant phase

• insignificant. Moreover, the use of variable magnetic fields of large amplitude requires the generation of strong electric currents, which may be unsafe in a medical clinic. In this regard, it seems more promising to use RMFs of moderate amplitude, H0 = 100–120 Oe, but at frequencies of about 400–600 kHz in

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• B. Rabindran Jermy Vijaya Ravinayagam Widyan A. Alamoudi Dana Almohazey Hatim Dafalla Lina Hussain Allehaibi Abdulhadi Baykal Muhammet S. Toprak Thirunavukkarasu Somanathan Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal

• University, P.O. Box 1982, 31441 Dammam, Saudi Arabia Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia Department of Neuroscience Research, Institute for

• Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia College of Engineering

BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

• Florence Olechowski,
• Rainer H. Müller and
• Sung Min Pyo

Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208

• inclusion; nanostructured lipid carriers (NLCs); penetration enhancement; skin occlusion; SmartLipids; solid lipid nanoparticles (SLNs); Introduction To meet the increasing expectations and demands of consumers in personal care and cosmetics, as well of patients in medical care, dermal delivery systems are

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• MRI as a medical technique, with the purpose of imaging soft body tissues and organs through the excitation of their atomic nuclei with high-frequency radio pulses and the measurement of the response in a strong magnetic field. Recent research has included using MRI for nanoscale imaging, enabling

• with high-spectral-resolution NMR spectroscopy is presented in [13]. In terms of future commercial products that permit nano-MRI to be undertaken at hospitals and for medical research, it will inevitably be required that they be produced in a way that secures the best trade-off between cost and

• 3D imaging by exploiting several spectral lines. Fourier/Hadamard transform techniques allow frequency–space multiplexing for faster measurement, where spatial information is recovered through Hadamard encoding and quadrature detection. Hyperpolarization is a novel functional medical imaging