Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• conjunction with focused ultrasound, and under magnetic resonance imaging guidance, for achieving blood/brain and blood/tumor barrier crossing of drugs [11][12]. Medical MBs have a shell consisting of surfactants, phospholipids, or polymers and are usually stabilized by a fluorocarbon gas [13] that acts as an

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• , University of Kent, Canterbury CT2 7NJ, United Kingdom Institute for Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany 10.3762/bjnano.10.201 Abstract Background: Nanoparticles are under investigation as carrier systems for anticancer drugs

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• .) on the sensing area. The sensitivity of the nanoengineered sensors is easily tunable by adjusting geometry-related parameters. For practical uses, sensors are not always used in ideal conditions. Especially, their use in dynamic human life, including health monitoring and medical applications

• to human life, medical, and health monitoring, the development of biosensors has received significant attention. For example, for the detection of bisphenol A, which is suspected as an endocrine disruptor, Piro et al. produced a nanoarchitectonic electrolyte-gated organic field-effect transistor with

• signals with an amplification factor of 200. This idea can be expanded to various practical sensing demands such as temporal monitoring during medical surgery and long-term implantable monitoring. Ingebrandt and co-workers also reported biosensors to monitor electrophysiological activity of the cardiac

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• , Jordan Yarmouk University - Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan Yarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan Hashemite University - Department of Medical Imaging, Zarqa, Jordan National Agricultural Research Center, Amman

• aperture 0.6; Olympus). Images were taken using a back-illuminated electron multiplying charge-coupled camera (Andor Technology, Belfast, Northern Ireland) Computed tomography (CT) scanning Scanning was performed three times (different days) on a multi-slice GE CT (Optima CT660) scanner (GE MEDICAL SYSTEMS

Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• ), MIPT, 141701 Moscow Region, Russia Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Moscow, Russia Laboratory of Biomedical Nanomaterials, NUST MISiS, Moscow Russia Mendeleev Chemical Technological University, Moscow, Russia 10.3762/bjnano.10.193 Abstract

• . Unlike gadolinium agents, these agents have fewer contraindications for patients with renal failure and are less toxic [9]. However, despite the fact that the iron-containing agents have been approved for medical use, they are considered to have inferior characteristics as compared to positive contrast

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• spectrometry (ICP-MS, Thermo Scientific iCAP 7400 series) [39]. T2-weighted MR imaging of the PNPs with various Fe concentrations was performed under a 3.0T clinical MRI scanner (DiscoveryMR750, GE Medical System, LLC, USA) at room temperature [27]. Fluorescent images of the PNPs with various Fe concentrations

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• Barbara Pem Igor M. Pongrac Lea Ulm Ivan Pavicic Valerije Vrcek Darija Domazet Jurasin Marija Ljubojevic Adela Krivohlavek Ivana Vinkovic Vrcek Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia University of Zagreb, School of Medicine, Croatian

• -chemical properties. Silver nanoparticles (AgNPs) are extensively used in antimicrobial coatings for medical devices, wound dressing, cosmetic products and food packaging due to their antimicrobial, antiangiogenic and anti-inflammatory properties [1][2][3][4][5]. Biomedical applications of gold

• nanoparticles (AuNPs) range from molecular imaging, targeted drug delivery, gene therapy, cancer treatment or radio-sensitization and theranostics [1][4][6]. Moreover, AgNPs and AuNPs are among the most investigated engineered nanomaterials for medical use. A search performed in the Web of Science (WoS

Growth dynamics and light scattering of gold nanoparticles in situ synthesized at high concentration in thin polymer films

• Corentin Guyot,
• Philippe Vandestrick,
• Ingrid Marenne,
• Olivier Deparis and
• Michel Voué

Beilstein J. Nanotechnol. 2019, 10, 1768–1777, doi:10.3762/bjnano.10.172

• solar infrared radiation [3][4], in random lasers [5][6], in non-linear optical applications [7][8][9] and in sensors or bio-medical diagnostics [10][11][12]. More recently, nanocomposites containing AuNPs received even more attention due to their saturable absorption. Indeed, plasmonic nanocomposites

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

• Carol López de Dicastillo,
• Cristian Patiño,
• María José Galotto,
• Yesseny Vásquez-Martínez,
• Claudia Torrent,
• Daniela Alburquenque,
• Alejandro Pereira and
• Juan Escrig

Beilstein J. Nanotechnol. 2019, 10, 1716–1725, doi:10.3762/bjnano.10.167

• (USACH), Obispo Umaña 050, 9170201 Santiago, Chile Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170124 Santiago, Chile Program Center for Applied Biomedical Research, School of Medicine, Faculty of Medical Sciences, University of Santiago de Chile, 9170022 Santiago, Chile

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

• Hannah Onafuye,
• Sebastian Pieper,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Klaus Langer and
• Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

• Münster, Corrensstr. 48, 48149 Münster, Germany Institute for Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany 10.3762/bjnano.10.166 Abstract Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• magnetocrystalline anisotropy at room temperature [10]. The anisotropy constant of CoFe2O4 (K = 2 × 105 J·m−3) is nearly one order of magnitude larger than that of Fe3O4 [11][12][13]. Fe3O4 NPs have been studied extensively for bio-medical applications, such as drug delivery [14], magnetic resonance imaging (MRI

Fe₃O₄ nanoparticles as a saturable absorber for giant chirped pulse generation

• Ji-Shu Liu,
• Xiao-Hui Li,
• Abdul Qyyum,
• Yi-Xuan Guo,
• Tong Chai,
• Hua Xu and
• Jie Jiang

Beilstein J. Nanotechnol. 2019, 10, 1065–1072, doi:10.3762/bjnano.10.107

• applications in ultrafast photonics, medical science, magnetic detection, and electronics. Very recently, FONPs were proposed as an ideal candidate for pulse generation in fiber-based oscillators. However, the pulses obtained to date are on the order of microseconds, which is too long for real application in

• , and optical modulators. Keywords: erbium laser; Fe3O4 nanoparticles; fiber lasers; saturable absorber; Introduction Fe3O4 nanoparticles (FONPs) are excellent magnetic materials, which allows for many applications in various fields such as medical transmission, microwave devices, and optical devices

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• Building, Crown Street, University of Liverpool, Liverpool, L69 7ZB, UK 10.3762/bjnano.10.104 Abstract The influenza (“flu”) type-A virus is a major medical and veterinary health concern and causes global pandemics. The peptide “FluPep” is an established inhibitor of influenza virus infectivity in model

Experimental study of an evanescent-field biosensor based on 1D photonic bandgap structures

• Jad Sabek,
• Francisco Javier Díaz-Fernández,
• Luis Torrijos-Morán,
• Zeneida Díaz-Betancor,
• Ángel Maquieira,
• María-José Bañuls,
• Elena Pinilla-Cienfuegos and
• Jaime García-Rupérez

Beilstein J. Nanotechnol. 2019, 10, 967–974, doi:10.3762/bjnano.10.97

• been demonstrated for several applications such as medical diagnosis, environmental monitoring or security control [4]. Most typical configurations of integrated photonic biosensors are based on the use of resonant or interferometric configurations, as it is the case of ring resonators or disks and

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• are foreign objects, careful evaluation of their toxicological and functional aspects prior to medical application is imperative. In this study, we aimed to determine the effects of gold and polymer-coated silica nanoparticles used in laser tissue soldering on brain endothelial cells and the blood

• metabolic state of cells have to be further characterized before use for medical purposes. Keywords: blood–brain barrier; laser tissue soldering; nanomedicine; nanoparticle uptake; rBCEC4 cells; Introduction Nanotechnology is commonly used in various fields, such as agriculture and pharmaceutical industry

• , and has gained further importance over the past few decades [1]. This technology also offers promising possibilities for medical applications such as tumor diagnostics and therapy, as drug carriers or in biodegradable implants, e.g., in laser tissue soldering (LTS) [2]. LTS provides a promising

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• -graphene oxide in different organs after different periods of time (mean ± standard deviation). Acknowledgements This research project was supported by a grant from the Research Center of the Female Scientific and Medical Colleges, Deanship of Scientific Research, King Saud University. The authors thank

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method

• important advantage of WS2 (and of other TMDCs) nanostructures over their carbon equivalents is the low toxicity and biocompatibility, enabling their use for medical applications. Preliminary studies on rats with WS2 INTs and IFs showed no apparent toxic reaction after oral administration [18], inhalation

• carbon equivalent and found the toxicity of the former to be lower [23]. Wu et al. produced biocompatible MoS2 nanoparticles by a pulsed laser ablation technique [24]. Examples of medical applications with TMDC nanostructures are their addition as reinforcing agents to polymers for bone-tissue

Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors

• Paula Martínez-Pérez and
• Jaime García-Rupérez

Beilstein J. Nanotechnol. 2019, 10, 677–683, doi:10.3762/bjnano.10.67

• interest in medical diagnosis, security, biodefense or industrial procedures, among other fields of application. For the design and fabrication of these sensing devices, huge efforts have been made in recent years to develop different transducers suitable for each application. According to the transducer

A carrier velocity model for electrical detection of gas molecules

• Ali Hosseingholi Pourasl,
• Sharifah Hafizah Syed Ariffin,
• Mohammad Taghi Ahmadi,
• Razali Ismail and
• Niayesh Gharaei

Beilstein J. Nanotechnol. 2019, 10, 644–653, doi:10.3762/bjnano.10.64

• . Graphene nanoribbons (GNRs) which have exceptional electrical, physical, and chemical properties can fulfil all of these requirements. The detection of gas molecules using gas sensors, particularly in medical diagnostics and safety applications, is receiving particularly high demand. GNRs exhibit

Nanocomposite–parylene C thin films with high dielectric constant and low losses for future organic electronic devices

• Marwa Mokni,
• Gianluigi Maggioni,
• Abdelkader Kahouli,
• Sara M. Carturan,
• Walter Raniero and
• Alain Sylvestre

Beilstein J. Nanotechnol. 2019, 10, 428–441, doi:10.3762/bjnano.10.42

• C/Al2O3 bilayers applied to medical devices exhibit a longer-term reliability in comparison to pure PPXC. The goal of this study is to improve the electrical properties of parylene C used in advanced electronic devices [52][53][54] as a gate dielectric or an insulation coating. The challenge is to

Advanced scanning probe lithography using anatase-to-rutile transition to create localized TiO₂ nanorods

• Julian Kalb,
• Vanessa Knittel and
• Lukas Schmidt-Mende

Beilstein J. Nanotechnol. 2019, 10, 412–418, doi:10.3762/bjnano.10.40

• ], fuel cells [20], lithium batteries [21][22][23][24][25][26], field-emission devices [27], data storage devices [28], gaso- and electrochromic displays [29][30], and nonlinear optical devices [31]. Even in the field of medical engineering, such structures are promising candidates for improving the

Sub-wavelength waveguide properties of 1D and surface-functionalized SnO₂ nanostructures of various morphologies

• Venkataramana Bonu,
• Binaya Kumar Sahu,
• Arindam Das,
• Sankarakumar Amirthapandian,
• Sandip Dhara and
• Harish C. Barshilia

Beilstein J. Nanotechnol. 2019, 10, 379–388, doi:10.3762/bjnano.10.37

• light during the medical process. Among metal oxides, SnO2 NWs, an n-type direct wide-band semiconductor (Eg = 3.6 eV at 300 K), was proved to be excellent sub-wavelength waveguide [3][4][5][6][7][12]. The high refractive index (n = 2.1) of SnO2 allows NWs with an optimal size range (100 to 500 nm) to

Heating ability of magnetic nanoparticles with cubic and combined anisotropy

• Nikolai A. Usov,
• Mikhail S. Nesmeyanov,
• Elizaveta M. Gubanova and
• Natalia B. Epshtein

Beilstein J. Nanotechnol. 2019, 10, 305–314, doi:10.3762/bjnano.10.29

• . However, for medical reasons, the product of these parameters should be restricted by a therapeutic limit, f × H0 ≤ 5 × 109 a/m/s [2][3]. Under this condition the alternating magnetic field is safe for healthy body tissues. Worth noting is that very large SAR values reported in a number of experiments [7

Study of silica-based intrinsically emitting nanoparticles produced by an excimer laser

• Imène Reghioua,
• Mattia Fanetti,
• Sylvain Girard,
• Diego Di Francesca,
• Simonpietro Agnello,
• Layla Martin-Samos,
• Marco Cannas,
• Matjaz Valant,
• Melanie Raine,
• Marc Gaillardin,
• Nicolas Richard,
• Philippe Paillet,
• Aziz Boukenter,
• Youcef Ouerdane and
• Antonino Alessi

Beilstein J. Nanotechnol. 2019, 10, 211–221, doi:10.3762/bjnano.10.19

• increasing need for optical, photonic and medical devices used in telecommunication, medicine, sensing and imaging applications [1][2] as well as in biology, sustainable development, chemistry and physics. In most cases, micro- or nanostructures are nowadays required in all these fields, thus the study of

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• Siyi Hu Yu Ren Yue Wang Jinhua Li Junle Qu Liwei Liu Hanbin Ma Yuguo Tang CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China School of Science, Changchun University of Science and