Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• invertebrate host; (ii) intracellular amastigote, a spherical form that is found in cells of the vertebrate host. Infected sandflies inject blood with the parasite in promastigote form into the vertebrate host, which causes macrophages or other cells of the mononuclear phagocytic system to phagocytose the

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• receptors after protein corona formation. Also, NPs that adsorb opsonins, such as immunoglobulins, complement components, and fibrinogen, on their surface are cleared from the body effortlessly by the mononuclear phagocytic system (MPS) [78]. The targeting efficiency of antibody-conjugated NPs is directly

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• system (RES) or the mononuclear phagocytosis system (MPS) [4]. The subsequent rapid clearance from blood circulation by the liver and kidneys results in insufficient drug accumulation in the target tissue [5]. In addition, NPs can interact with proteins to form a protein corona, which affects the

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• targeting efficacy of nanomedicines. Various solutions have been proposed to improve mononuclear phagocytic system (MPS) evasion, extravasation at the tumor site, and diffusion through the dense collagen matrix of the solid tumors. Biomimetic, multifunctional, and multistage targeted nanoscale delivery

In search of cytotoxic selectivity on cancer cells with biogenically synthesized Ag/AgCl nanoparticles

• Mitzi J. Ramírez-Hernández,
• Mario Valera-Zaragoza,
• Omar Viñas-Bravo,
• Ariana A. Huerta-Heredia,
• Miguel A. Peña-Rico,
• Erick A. Juarez-Arellano,
• David Paniagua-Vega,
• Eduardo Ramírez-Vargas and
• Saúl Sánchez-Valdes

Beilstein J. Nanotechnol. 2022, 13, 1505–1519, doi:10.3762/bjnano.13.124

• tested on mononuclear cells. Ag/AgCl nanoparticles with spherical and triangular morphology were obtained. The size of the nanoparticles (10–70 nm) and the size distribution depended on the reaction temperature. A dose close to 20 µg/mL of Ag/AgCl nanoparticles considerably decreased the cell viability

• tested in mononuclear cells, particularly in monocytes. The results of the cytotoxic behavior of these systems are shown in Figure 10. It is evident that nanoparticles obtained at temperatures of 60 and 80 °C were also cytotoxic to monocytes at concentrations of 25 µg/mL. In fact, their IC50 was lower

• mononuclear cells (PBMC) and in breast cancer cells (MCF-7) are shown in Table 3. The maximum concentration of AgNO3 tested was the one used to generate the Ag/AgCl nanoparticles. Even at the lowest concentrations, a significant decrease in cell viability was observed. The data indicated that AgNO3 had strong

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• and a reduced toxicity to normal cells of free drug molecules. Surface modification of the nanomaterials with polyethylene glycol (PEG) is reported to be advantageous for multiple reasons, such as inhibition of recognition by the mononuclear phagocytic system, elimination of in vitro toxicity, and

Low-energy electron interaction and focused electron beam-induced deposition of molybdenum hexacarbonyl (Mo(CO)₆)

• Po-Yuan Shih,
• Maicol Cipriani,
• Christian Felix Hermanns,
• Jens Oster,
• Klaus Edinger,
• Armin Gölzhäuser and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2022, 13, 182–191, doi:10.3762/bjnano.13.13

• these are commercially available, have comparatively high vapor pressure and are fairly stable and easy to handle. Correspondingly metal carbonyl complexes, including the mononuclear Ni(CO)4, Cr(CO)6, Fe(CO)5, W(CO)6 and Mo(CO)6, have been used as precursors to deposit metals on surfaces through FEBID

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• improved pharmacokinetics. Their hydrophobicity makes them promising to achieve controlled release and targeted drug delivery to the mononuclear phagocyte system [65]. Effects on the stability of SLN have been reported during storage, mostly due to loss of the solid crystalline structure, which can cause

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

• Khosro Adibkia,
• Ali Ehsani,
• Asma Jodaei,
• Ezzatollah Fathi,
• Raheleh Farahzadi and
• Mohammad Barzegar-Jalali

Beilstein J. Nanotechnol. 2021, 12, 786–797, doi:10.3762/bjnano.12.62

• ]. Briefly, five rats were euthanized using ketamine/xylazine (87/13 mg/kg). After surgery and removal of femur and tibia, BM contents were flushed using washing buffer. Next, the BM contents was layered over Ficoll-Paque (Innotrain, Germany) and mononuclear cells were re-suspended in DMEM supplemented with

Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells

• Sahar Pourhoseini,
• Reilly T. Enos,
• Angela E. Murphy,
• Bo Cai and
• Jamie R. Lead

Beilstein J. Nanotechnol. 2021, 12, 282–294, doi:10.3762/bjnano.12.23

• human cells (peripheral blood mononuclear cells (PBMCs)). AgNPs were synthesized in-house and characterized using a multimethod approach. Results indicated the transformation of NPs in RPMI medium with a change in size and polydispersity over 24 h of exposure due to dissolution and reprecipitation. No

• , characterization, and study of transformations to obtain a better understanding of NP uptake and toxicity. Statistical analysis indicated that there might be an individual variability in response to NPs, although more research is required. Keywords: human peripheral blood mononuclear cells; silver ions; silver

• dermal and ocular contact [18]. As AgNPs enter the body through injection or degradation of biomaterials, they are translocated to the circulatory system and can come in direct contact with human peripheral blood mononuclear cells (PBMCs) before ultimately being distributed to the main organs where they

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• mononuclear phagocyte system (MPS), and promote their cellular uptake and in vivo stability. TEM images of shortened and of functionalized CNTs are shown in Figure 2 and Figure 3 (with different magnifications), respectively. TEM images show that the raw SWCNTs are long curved aggregates, which appear to be a

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

• Alfredo Nuñez-Rivera,
• Pierrick G. J. Fournier,
• Danna L. Arellano,
• Ana G. Rodriguez-Hernandez,
• Rafael Vazquez-Duhalt and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28

• limited because only a small fraction of the administered dose of the drug arrives into the tumors [1][2][3]. This can be attributed, in part, to a series of biological barriers that reduce the drug accumulation in tumors [4] such as sequestration by the mononuclear phagocyte system [5], non-specific

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• bodies and taken care of by opsonins, leading to their handling by the mononuclear phagocyte system. Carriers avoiding detection by opsonins had then to be developed and very common polymers, namely poly(ethylene glycol) (PEG) or poly(ethylene oxide) (PEO), were found to fulfil this requirement [6]. In

• proteins and adhesion to cells [108][109]. A hydrophobic cargo, well within the hydrophobic core is thus protected from hydrolysis and enzymatic degradation. Besides, PEO prevents the recognition from the mononuclear phagocyte system and preliminary clearance from the bloodstream is reduced. Although PEO

• hydrophilic block, effectively rendering the self-assemblies highly negatively charged at physiological pH values. Indeed, negatively charged nanoparticles are known to be capable of evading the mononuclear phagocyte system and enjoy prolonged blood circulation [58][110]. Active targeting through hydrophilic

Self-assembly of a terbium(III) 1D coordination polymer on mica

• Quentin Evrard,
• Giuseppe Cucinotta,
• Felix Houard,
• Guillaume Calvez,
• Yan Suffren,
• Carole Daiguebonne,
• Olivier Guillou,
• Andrea Caneschi,
• Matteo Mannini and
• Kevin Bernot

Beilstein J. Nanotechnol. 2019, 10, 2440–2448, doi:10.3762/bjnano.10.234

• embedded in a suitable electrostatic environment. Indeed, mononuclear single-molecule magnets (SMMs), which are objects showing magnetic hysteresis at the molecular level comprising only one metallic ion (instead of a collective assembly of ions), have been initially observed for a Tb-based molecule [13

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• the blood–brain barrier. Incubation of peripheral blood mononuclear cells with citrate and mixed-matrix gold nanoparticles demonstrates that the mixed-matrix ligand shell markedly reduces the reaction of the peripheral blood mononuclear cells to the nanoparticles [48]. Therefore, whilst it remains to

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• -affinity proteins, for example immunoglobulins, facilitate phagocytosis by cells of the mononuclear phagocyte system (MPS) [26]. Furthermore, one has to consider that the ratio between NP surface and protein concentration is closely related to the administration route and dose [27]. As a result

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

• Sašo Gyergyek,
• David Pahovnik,
• Ema Žagar,
• Alenka Mertelj,
• Rok Kostanjšek,
• Miloš Beković,
• Marko Jagodič,
• Heinrich Hofmann and
• Darko Makovec

Beilstein J. Nanotechnol. 2018, 9, 1613–1622, doi:10.3762/bjnano.9.153

• the carbon–oxygen stretching vibration and the difference between the asymmetric and symmetric stretching-vibration frequencies relative to the free carboxylate ion are indicative of a mononuclear bidentate complex. The absorption peak at 1736 cm−1, indicative of ester groups, is significantly

Electron interaction with copper(II) carboxylate compounds

• Michal Lacko,
• Peter Papp,
• Iwona B. Szymańska,
• Edward Szłyk and
• Štefan Matejčík

Beilstein J. Nanotechnol. 2018, 9, 384–398, doi:10.3762/bjnano.9.38

• investigated molecules as the highest unoccupied molecular orbital of the studied complexes has Cu–N and Cu–O antibonding character. For all complexes, formation of the Cu2(O2CC2F5)4−• anion is observed together with mononuclear DEA fragments Cu(O2CC2F5)3−, Cu(O2CC2F5)2− and Cu(O2CC2F5)−•. All dominant DEA

Synthesis of [{AgO₂CCH₂OMe(PPh₃)}_n] and theoretical study of its use in focused electron beam induced deposition

• Jelena Tamuliene,
• Julian Noll,
• Peter Frenzel,
• Tobias Rüffer,
• Alexander Jakob,
• Bernhard Walfort and
• Heinrich Lang

Beilstein J. Nanotechnol. 2017, 8, 2615–2624, doi:10.3762/bjnano.8.262

• keV regime (typical primary electron regime, forward and backscattered electrons) [19]. Hence, 50 possible fragmentation routes of mononuclear 2 under low electron impact were studied. The appearance energy Eap was calculated for all ions shown below (2) (Et = total energy of neutral 2, Ei = total

• for the formation of Ag− and at least 1.21 eV for the decarboxylation of the negatively charged O2CCH2OMe− fragment. Fragmentation according to pathway B The formation of [AgO2CCH2OMe] from neutral mononuclear 2 requires less energy than the removal of Ag from mononuclear 2 (Table 3). It was found

• , according to the lowest energy pathways, is equal to 1.19 or 1.30 eV. It is larger than the Eap of anionic Ag− directly from [AgO2CCH2OMe(PPh3)]. In conclusion, the decomposition of mononuclear 2 under FEBID conditions occurs preferably via pathway A, when compared to B. Fragmentation accordingly to pathway

Electron beam induced deposition of silacyclohexane and dichlorosilacyclohexane: the role of dissociative ionization and dissociative electron attachment in the deposition process

• Ragesh Kumar T P,
• Sangeetha Hari,
• Krishna K Damodaran,
• Oddur Ingólfsson and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2017, 8, 2376–2388, doi:10.3762/bjnano.8.237

• observations to the actual conditions in FEBID. A fairly comprehensive account of these studies up to early 2015 is given in [13]. This is however a fast-moving field and a considerable number of studies have appeared recently [21][22][23][24][25][26][27][28][29], including studies on a mononuclear

The interplay between spin densities and magnetic superexchange interactions: case studies of mono- and trinuclear bis(oxamato)-type complexes

• Azar Aliabadi,
• Bernd Büchner,
• Vladislav Kataev and
• Tobias Rüffer

Beilstein J. Nanotechnol. 2017, 8, 2245–2256, doi:10.3762/bjnano.8.224

• is given by the countless derivatization offered by carbon chemistry. They allow for altering chemical structures and, in doing so, to tune magnetic properties of molecular spin-carrying compounds. With emphasis on the interplay of the spin density distribution of mononuclear and magnetic

• the following we aim to review on efforts to determine the spin density distribution of mononuclear type-II and related complexes by ESR spectroscopy as a measure of the magnetic superexchange interactions of their related trinuclear type-III complexes. Review The concept The spin density of the NCO

• corresponding type-II complexes are [9]. Now, we turn towards the pairs of structurally related mononuclear complexes displayed in Figure 1 and to compare the obtained results with the one reported for the combination of 2@1. As Figure 1 illustrates, we successively replaced O atoms with N–R units. If otherwise

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• particle size of nanoparticulate drug delivery systems play a direct and important role on cellular uptake, systemic circulation, toxicity and stability of nanoparticles [37][38]. It was reported that nanoparticles smaller than 200 nm can escape recognition by the mononuclear phagocytic system (MPS) [39