Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• Structures, School of Resources, Environment and Materials, Guangxi University, Nanning, Guangxi 530004, China 10.3762/bjnano.16.149 Abstract Herein we point out critical yet often overlooked barriers restraining the real-world impact and commercial viability of nanomaterials research. In spite of decades

• remain unrealized, despite over decades of excellent discoveries. This perspective calls for carefully considerations linked to productivity perception, true funding utility, and foundational reform to unlock nanotechnology’s full promise across sectors. Keywords: commercialization; nanomaterials

• ; public-facing technologies; standardization; translational barriers; Perspective Atom-by-atom innovation The historical creation of nanomaterials and their applications is much older than often assumed and has long been a subject of debate. It would be wrong to believe that nanomaterials have been

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• application of nanomaterials for microplastic removal is elaborated in detail, and case studies validated their effectiveness, especially in cold environments with strong UV irradiation. In the face of increasing worldwide research into microplastic contamination, there remains a huge knowledge gap concerning

• permanently removed without causing secondary pollution [72]. 5.3.2 Nanotechnology for degradation. Nanotechnology offers a novel method for the accurate and effective breakdown of MPs. Under UV light, nanomaterials such as ZnO and TiO2 work as photocatalysts to break down MPs into CO2 and water, which are

• nanoparticles have been shown to break down PS in both UV and natural light, which suggests they could be used in a range of environmental conditions [44]. Another prospective application is the integration of nanomaterials into filtration membranes, which results in the development of hybrid systems that are

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• enabled us to extrapolate trends for electron transport in thicker multilayer carbon and h-BN materials. Keywords: NEGF; DFT; nano-junction; Introduction Multilayer graphene nanomaterials exhibit interesting electronic properties and find application in battery electrode materials [1], electrocatalysis

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , chemical, or biological attributes offer novel foundational elements for the design and development of devices and systems aimed at diagnosing and treating various diseases. Hence, nanoparticles or nanomaterials can be engineered to have various useful medical functions [4]. The assessment of the

• biological activity (e.g., antioxidant, antimicrobial, and anticancer) of nanomaterials has emerged as a crucial area of investigation in the field of nanoscience and nanotechnology. In many studies, chemically or biologically synthesized nanoparticles have a wide range of pharmacological activity ranging

• avenue for the development of targeted cancer therapies by leveraging this inherent selectivity. Although direct mechanistic assays such as ROS quantification or apoptosis marker analysis were not performed in this study, previous research on silver-based nanomaterials offers valuable insights into

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• Michal Bartkowski Francesco Calzaferri Silvia Giordani School of Chemical Sciences, Dublin City University, Glasnevin, Dublin, Ireland Life Science Institute, Dublin City University, Glasnevin, Dublin, Ireland 10.3762/bjnano.16.144 Abstract Carbon nanomaterials (CNMs), including graphene, carbon

• enhancing therapeutic delivery, particularly in areas such as cancer treatment. This perspective highlights critical considerations in the development of CNM-based nanocarriers, spanning from initial design to clinical implementation. Keywords: carbon nanomaterials (CNMs); carbon nanoparticles (CNPs); drug

• delivery systems (DDSs); nanocarriers; quality control (QC); Introduction Nanomaterials Nanomaterials (NMs) have an extensive array of various properties and applications across many industries, including the biomedical, health care, food/agriculture, industrial, environmental, electronic, and renewable

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• heterogeneous nanomaterials while significantly simplifying the requirements for probe selection, which are typically necessary for material differentiation via the standard PeakForce tapping method. This innovation enhances the technique’s practicality and extends compatibility to a wider array of probe types

• low-pass filtering effectively suppress parasitic vibrations and baseline drift, ensuring sub-nanometer topographic resolution. This method offers a practical new tool for characterizing heterogeneous nanomaterials, particularly in scenarios where probe selection is limited or multiparameter

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• Natalie Tarasenka Department of Design, Manufacturing and Engineering Management, University of Strathclyde, 75 Montrose st., G1 1XQ, Glasgow, UK 10.3762/bjnano.16.137 Abstract Shape-and size-controlled synthesis of nanomaterials has been a long-term aim and challenge of modern nanotechnology

• . Despite many synthesis methods are still mainly focused on the production of near-spherical NPs, a number of emerging applications require nanomaterials of nonspherical shape and developed surface, which determine the functional performance of nanostructured devices. Laser ablation in liquids has been

• stage of the development of laser ablation in liquids from the perspective of shape control of the forming nanomaterials. The key parameters influencing the NP shape are highlighted, including the composition of a liquid, laser focusing conditions and introduction of external fields, and the mechanism

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• . Acknowledgements We would like to acknowledge members of the FIT4NANO Action (COST: CA19140 - Focused Ion Technology for Nanomaterials) for sharing their knowledge. The flask icon in the graphical abstract is from https://openclipart.org/detail/16987/erlenmeyr under the CC0 License, by jean_victor_balin. Funding

• We would like to acknowledge the support of the FIT4NANO Action (COST: CA19140 - Focused Ion Technology for Nanomaterials) for funding the scientific activities. This research was supported in part by the Excellence Initiative - Research University Program at the Jagiellonian University in Krakow and

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• ; sustainable development; Introduction Nanotechnology is an interdisciplinary field of science that involves the manipulation of materials at the nanoscale, typically ranging from 1 to 100 nm in inorganic nanomaterials, to generate structures with unique physicochemical properties [1][2][3]. Among the most

• widely studied nanomaterials are metallic nanoparticles, particularly silver (AgNPs), gold (AuNPs), and copper (CuNPs), and various metal oxide nanoparticles such as zinc oxide (ZnO-NPs), due to their high surface-to-volume ratio, chemical stability, and distinctive optical and antimicrobial properties

• [4][5][6]. These nanomaterials have been successfully applied in diverse fields, such as medicine, agriculture, cosmetics, electronics, the food industry, and, more recently, dentistry [5][6]. However, conventional chemical and physical synthesis routes often involve toxic organic solvents, high

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• sustainable strategies to deal with this matter. Many studies have shown that adsorbent nanomaterials have potential for the removal of MPs from water. This review evaluates the current status of using adsorbent nanomaterials in removing MPs from water supply systems. It discusses the occurrences and removal

• efficiency of MPs in water supply systems, as well as the mechanisms and performance when applying these materials for treatment. In addition, the related risk of adsorbent nanomaterials is also considered. Microplastics from land-based sources and wastewater plants persist in water supplies, with

• conventional treatments removing only 40–70%, especially struggling with smaller particles. Based mainly on mechanisms like electrostatic interactions, hydrophobic interactions, pore filling, hydrogen bonding, π–π stacking, and surface complexation, adsorbent nanomaterials achieve over 90% removal of MPs and

Piezoelectricity of layered double hydroxides: perspectives regarding piezocatalysis and nanogenerators

• Evgeniy S. Seliverstov,
• Evgeniya A. Tarasenko and
• Olga E. Lebedeva

Beilstein J. Nanotechnol. 2025, 16, 1812–1817, doi:10.3762/bjnano.16.124

• (e.g., 95.8% degradation of carbamazepine, k ≈ 0.148 min−1 for ultrathin Zn/Al-LDH; 91.50% norfloxacin degradation, k ≈ 0.1644 min−1 for ZnCo/Al-LDH); also, it is useful to compare them with benchmark non-LDH piezocatalysts. For example, BaTiO3 nanomaterials, long considered a standard for

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• structural modification. [26]. Aptamer-based biosensors [27] fully utilize these characteristics by combining various signal amplification techniques and nanomaterials (such as metal nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes), enabling highly sensitive detection of biomarkers

• drug loading and release efficiency with nanomaterials as carriers, significantly optimizing the treatment mode of EC. 2 Searching core literature In order to better summarize the application of aptamers in the diagnosis, treatment, and drug delivery of EC, we searched for keywords in the PubMed and

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• effectively removing MPs, especially those in the nanosize range. This review presents a detail analysis of the sources, pathways, detection methods, and health impact of MPs, while emphasizing the emerging role of nanotechnology in their remediation. Nanomaterials, including nanoadsorbents, photocatalysts

• various nanoenabled treatment strategies such as adsorption, photocatalysis, and membrane filtration using materials like metal-organic frameworks, carbon-based nanomaterials, MXenes, and metal oxides. It also highlights recent innovations such as microrobotic systems and AI-assisted detection frameworks

• nanoparticles, minimizing the used of hazardous chemicals [17]. Together, these techniques offer versatile strategies for developing nanomaterials that can be fine-tuned to optimize microplastic removal efficiency while adhering to sustainable practices. In the field of water treatment, nanotechnology has been

Modeling magnetic properties of cobalt nanofilms used as a component of spin hybrid superconductor–ferromagnetic structures

• Aleksey Fedotov,
• Olesya Severyukhina,
• Anastasia Salomatina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2025, 16, 1557–1566, doi:10.3762/bjnano.16.110

• are currently used, as well as fundamental features of the thin film formation processes with new composition and coatings of various types. These types of nanomaterials are very promising (in terms of computational performance and energy dissipation efficiency) for use in superconducting digital

• Josephson contacts [13]. These nanomaterials are widely used [17][18][19] in the creation of individual qubits and quantum computers in general, superconducting microcircuits and interferometers, single photon detectors [20] and other devices of quantum electronics and spintronics. Mathematical Model for

• ] indicates a satisfactory qualitative and quantitative agreement of the values. This analysis confirms that the modeling of magnetic properties and behavior of nanomaterials at the atomistic level should be carried out at integration time steps of no more than 1.0 fs. Typical spin dynamics models use a time

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• become an emerging field of research [3][4][5][6][7]. The expanding application areas require silicon nanomaterials of different morphologies, including quantum dots, nanowires, and nanocrystalline films. Si nanowires, for example, are considered as a promising alternative to silicon electrodes in Li-ion

• to alter the properties and morphology of NPs by changing the laser parameters and liquid media [10][11]. The control over the major characteristics of the produced nanomaterials can be achieved by adjustment of several experimental parameters, for example, laser wavelength, fluence, pulse width

• laser beam energy distribution (Gauss, Bessel, or annular) for the synthesis of silicon nanomaterials of different shapes by laser ablation in a liquid. The advantages of laser beams with Bessel and annular profiles were demonstrated earlier in the fields of material processing, such as microdrilling

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• reverse osmosis [9]. The adsorption process stands out as a promising approach due to its high efficiency, cost-effectiveness, ease of processing, and capability to recover trace metal ions [10][11][12][13]. This process utilizes nanomaterials bearing appropriate functional groups to bind metal ions

• , which can be later released by altering the pH of the solution. Numerous nanomaterials have been explored and modified by introducing a high number of binding sites (functional groups) and/or generating a porous structure to enhance the adsorption of heavy metal ions [14][15]. Although such modified

• dendrimers on a solid support can also improve the dispersibility, accessibility of binding sites, chemical recyclability, and mechanical stability [16][17]. In fact, dendrimers have been supported by various nanomaterials such as silica, graphene oxide, and carbon nanotubes (CNTs), broadening their

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• functional biomedical nanomaterials. However, few studies report the controls performed to determine if the loading of molecules onto IONPs is due to the proposed coupling reaction(s) employed, or some other unknown interaction with the IONP surface. Herein, we use 3,4-dihydroxybenzoic acid-functionalized

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• , Istanbul, Turkey 10.3762/bjnano.16.105 Keywords: biomedical applications; drug delivery; nanocarriers; nanomaterials; nanomedicine; nanoparticles; polymeric nanoparticles; tissue regeneration; Medicine has rapidly advanced over the last few decades, and nanotechnology has played a significant role in

• this progress. The use of nanomaterials has notably contributed to advancements in the fields of disease diagnosis, treatment, and prevention. They can closely interact with cells and molecules of the body due to their small size, which helps to diagnose, enhance imaging, and repair damaged tissues

• . Nanomaterials have gained popularity in medicine because they can be altered according to the need [1]. Researchers can tailor the shape, surface chemistry, and other specific properties of materials to deliver desirable traits. In particular, some nanoparticles can be used to deliver drugs to a tumor, reducing

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• , electrochemical/photoelectrochemical sensors, hydrogen/oxygen evolution, SERS sensors and other types of devices reported so far. The last section explains the challenges and further scope of these devices from laser-generated nanocolloids. Keywords: HER/OER/water splitting; laser synthesis of nanomaterials

• . These techniques have been important for progress in this field of study. 1.1 Laser ablation in liquids Laser ablation in liquids (LAL) is a well-established technique for synthesizing nanomaterials such as metals, semiconductors, ceramics, polymers, and alloys. Several review articles published since

• [12]. The size, shape, and composition of these nanomaterials can be controlled by adjusting experimental parameters such as laser settings, liquid medium, and target material. Additionally, the preparation of doped and multicomponent semiconductor nanostructures could expand LAL’s potential in

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• , the surfaces of the silver nanomaterials (initial AgNP seeds, planar twinned seeds) are continuously excited, and the growth of AgNPrs proceeds via two mechanisms (Figure 6). These mechanisms are: (1) TSC continues to be excited and promotes the reduction of Ag+, resulting in the deposition of Ag0 on

• C–H stretching modes [21][22]. These findings demonstrate the SERS-enhancing capability of the silver nanomaterials synthesized in this study. The SERS enhancement effect of each nanomaterial was evaluated based on the intensity of the 1589 cm−1 peak. Overall, AgNPrs exhibited significantly stronger

• ]: where ISERS and Ibulk are the Raman intensities of 4-MBA in the presence and absence of silver nanomaterials, respectively. NSERS and Nbulk are the number of 4-MBA molecules excited by the laser under SERS and non-SERS conditions, respectively. Since the same volume (20 µL) and method were used, NSERS

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• membrane surface, significantly reduces the efficiency of water production [16]. Therefore, there is an urgent need to enhance membrane properties to achieve both high permeability and high selectivity while improving resistance to biological contamination. Antibacterial nanomaterials have garnered

• significant attention for their ability to enhance the antibacterial properties of membrane materials, effectively addressing critical issues such as biofouling and microbial contamination in water treatment systems. These nanomaterials, characterized by their high surface area-to-volume ratio, tunable

• surface properties, and quantum effects, collectively enhance their antimicrobial efficacy [17]. The high surface area-to-volume ratio of nanomaterials facilitates efficient interactions with microorganisms, thereby enhancing their antimicrobial efficacy [18]. Additionally, the surface properties of

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• marked by an accumulation of PUFAs and a lack of reduced GSH, making these cells susceptible to ferroptosis [84]. Due to their vast therapeutic potential, ferroptosis inducers have attracted significant attention in cancer research. Additionally, different nanomaterials have been created to trigger

Deep-learning recognition and tracking of individual nanotubes in low-contrast microscopy videos

• Vladimir Pimonov,
• Said Tahir and
• Vincent Jourdain

Beilstein J. Nanotechnol. 2025, 16, 1316–1324, doi:10.3762/bjnano.16.96

• situ imaging platforms for nanomaterials, such as environmental transmission electron microscopy (ETEM) of CNTs [31][33] and environmental scanning electron microscopy (ESEM) of graphene growth and etching processes [34]. Snapshots from (a) the raw video of carbon nanotube (CNT) synthesis on a stable