Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• temperature. They are much smaller than the bulk value (65.8 emu/g). The decrease in the saturation magnetization of the CF/GQDs is attributed to the presence of the nonmagnetic GQDs. The particles’ high magnetic permeability shows that they could be separated with an external magnetic field. The Mr values of

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• vascular endothelial cells are at low frequency, and that the trans-endothelial pathways are the dominant mechanisms for nanoparticle extravasation in tumors (also called enhanced permeability and retention (EPR) effect) [37]. Since the skin has a denser structure than that of tumor vessels, we speculated

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• still required regarding a realistic use of nanomedicines effective against CD. Keywords: benznidazole; liposomes; nanocrystals; nanomedicines; nanoparticles; Trypanosoma cruzi; Introduction Nanomedicines are used to solve the problems posed by poor solubility and/or permeability and high toxicity of

• released BNZ available for absorption [39][40]. Other studies determined the release profile of BNZ in different media [41][42][43][44] and its permeability across Caco-2 cells [43][44]. Between 2012 and 2018 the BERENICE (BEnznidazol and triazol REsearch group for Nanomedicine and Innovation on Chagas

• lipophilicity indicator and the most critical parameter predictor of passive membrane permeability (which for BNZ is 0.9; a clogP value below 1.35 is indicative of low permeability) [29][55]. In contrast, others consider BNZ as a class-IV drug, this is, a poorly soluble and poorly permeable molecule [30] with

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• a vital role in adhesion to the hydro–water interface and solid surfaces, providing an idea about the viability and permeability of the cell membrane under stress. As most of the cell surface carries a negative charge, metals with higher zeta potential can easily enter the cell and increase the

Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane

• Shangbi Chen,
• Dewen Liu,
• Weiwei Chen,
• Huajiang Chen,
• Jiawei Li and
• Jinfang Wang

Beilstein J. Nanotechnol. 2024, 15, 270–278, doi:10.3762/bjnano.15.25

• permeability of vacuum (4π × 10−7 N·A−2), and k is the aspect ratio correction factor, which relies on the ratio between coil diameter D and length L0, as shown in Figure 3a. Figure 3b depicts the alteration in inductance as a function of the strain. The helical index of this sensor is 1, while its length is 2

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• , as they increase permeability and retention effect in solid tumors, enabling precise application to the targeted cells. Various structures such as silica-based conjugates, inorganic polymers, ceramic nanomaterials, gold, iron oxide, and noble metal nanoparticles have been utilized [9][10]. Among the

• photothermal therapy capabilities, the PDA shell mitigates nanomaterial toxicity while increasing biocompatibility. The strategic integration of PEGylation into tumor-targeted drug delivery systems significantly amplifies passive tumor targeting and retention through the enhanced permeability and retention

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• of NR composite. The usage of GO-VTES may be suitable for the preparation of NR composites for tire applications as the composite may reduce water permeability and enhance the abrasion resistance of commercial products [30]. Experimental Materials The natural rubber used in this work is high-ammonia

Ferromagnetic resonance spectra of linear magnetosome chains

• Elizaveta M. Gubanova and
• Nikolai A. Usov

Beilstein J. Nanotechnol. 2024, 15, 157–167, doi:10.3762/bjnano.15.15

• derivatives of magnetic permeability with respect to the magnetic field, confirm the above conclusions about the influence of the number of particles in linear chains and the value of the magnetic damping constant on the FMR spectrum. There are convincing arguments [41] that E-type anisotropy is realized in

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• history and a wide range of applications, especially in biology, medicine, tissue engineering, and pharmacy. The multitude of application areas is related to their exceptional properties: biocompatibility, biodegradability, nontoxicity, good permeability for substances dissolved in water (e.g., oxygen and

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• clinical use. In recent years, different nanostructured systems have been explored, such as lipid nanoparticles, metallic nanoparticles, polymeric nanoparticles, nanovesicles, and self-emulsifying nanosystems. These can promote increased solubility, permeability, protection against degradation in

• administration routes, which takes into consideration the biological barriers involved in the treatment of different forms of leishmaniasis (VL, CL, and MCL). This rationale is based on the lack of information observed in the studies regarding skin permeability on lesioned and healed skin, and gastric stability

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• ]. Praziquantel is a class II compound according to the biopharmaceutical classification system (BCS), so it has low solubility and high permeability in the gastrointestinal tract [6]. This drug is affected by the first-pass effect on the liver, which also impacts its bioavailability [6]. Unfortunately, this

• permeability through the cellular membrane by making a nanoemulsion of Curcuma longa extract (i.e., the curcumin plant source). The nanoemulsion showed an effect against adults of S. mansoni in vitro (especially males). This is an interesting finding because data from the literature reports that females are

TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes

• Joshua Williams,
• Michael I. Faley,
• Joseph Vimal Vas,
• Peng-Han Lu and
• Rafal E. Dunin-Borkowski

Beilstein J. Nanotechnol. 2024, 15, 1–12, doi:10.3762/bjnano.15.1

• –iron alloy (80 atom % Ni and 20 atom % Fe) that has a small coercive field (Hc) [17] and low magnetostriction (λs) [18], as well as high permeability and high saturation magnetization (Ms) [19]. TEM offers high spatial resolution for magnetic imaging. TEM-based magnetic imaging techniques such as

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• the interaction with mucus in vitro, they demonstrated that the apparent permeability coefficient (Papp value) through porcine intestinal mucus as well as the diffusion determined by particle tracking is significantly higher for softer particles. However, as soon as cells are included in the system

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• HSA-MPs reflects the negative charge of the albumin biopolymers [26]. In fact, in the cationic HSA-MPs with negative charges, CUR loading did not alter the zeta potential of CUR-HSA-MPs. Furthermore, particles with negative surface charge exhibit the enhanced permeability and retention (EPR) effect

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• circulation time and serum stability. Also, they enable drug release in a sustained and controlled manner [4]. Targeted delivery of drug-loaded NPs can be achieved either through passive targeting, where drugs accumulate in tumor tissues via the enhanced permeability and retention (EPR) effect, or through

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• (Benznidazole Evaluation for Interrupting Trypanosomiasis) trial could not prove that the standard treatment with BNZ can prevent disease progression [11]. BNZ has been classified as a class IV drug (low solubility, low permeability) in the Biopharmaceutics Classification System (BCS) [12]. It has an apparent

• volume of distribution (Vd) of 0.56 L/kg, and reactive products of its metabolism [13]. Such Vd and low permeability values across biological barriers could result in difficulties for BNZ to reach intracellular amastigotes. The encapsulation of BNZ within nanoscale pharmaceutical carriers has been

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• cytoplasm and cell wall, leading to increased permeability and, eventually, disruption of the bacterial cell wall [26]. This disruption can deactivate respiratory enzymes, resulting in the generation of reactive oxygen species [27] and the inhibition of adenosine triphosphate release [26]. The antibacterial

Investigations on the optical forces from three mainstream optical resonances in all-dielectric nanostructure arrays

• Guangdong Wang and
• Zhanghua Han

Beilstein J. Nanotechnol. 2023, 14, 674–682, doi:10.3762/bjnano.14.53

• perpendicular to and pointing toward the outside of the surface, and ⟨Tij⟩ is the time-averaged MST [18] defined by where the indices i and j denote x, y, or z components of the electric or magnetic field; εr and μr are the relative permittivity and the relative permeability of the surrounding medium

ZnO-decorated SiC@C hybrids with strong electromagnetic absorption

• Liqun Duan,
• Zhiqian Yang,
• Yilu Xia,
• Xiaoqing Dai,
• Jian’an Wu and
• Minqian Sun

Beilstein J. Nanotechnol. 2023, 14, 565–573, doi:10.3762/bjnano.14.47

• . Their relationship can be expresses as: where εr is the complex permittivity, εr = ε′ − jε″, μr is the complex permeability, μr = μ′ − jμ″, ƒ is the frequency, d is the thickness of the material, and c is the speed of light. The microwave absorption of the SCZ samples strongly depends on the dosage of

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

• surrounding medium [63]: PLSPR is the power absorbed by the nanoparticle, ε0 and μ0 are, respectively, the permittivity and permeability of vacuum, nm is the refractive index of the surrounding medium, and is the amplitude of the transverse incident wave of the laser source. Equation 24 can be simplified in

Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

• Magdalena Lasak and
• Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

• bidirectional vascular permeability, which may contribute to the formation of cancer metastases. In this review we are focusing on the effect of metal and polymeric NPs on mechanism and degree of induction of NanoEL, as well as on the benefits and risks of using NPs that induce endothelial leakiness. Keywords

• : endothelial leakiness; metal nanoparticles; NanoEL; nanotoxicity; vascular permeability; Review Introduction The vascular barrier is a highly selective boundary between blood and tissues. Its proper functioning is essential to maintaining homeostasis of the whole organism. Formed from mesodermal endothelial

• extracellular signals and regulate the function of the vascular barrier [3]. The endothelium is also covered by a negatively charged layer of glycocalyx, which has a protective function and is involved in the transport of molecules across the endothelium [11][12]. The degree of endothelial permeability depends

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• BBB permeability, which restricts the treatment of brain-related diseases [49]. Aggressive metastases to brain tumors are common in various types of tumors, such as melanoma, lung cancer, and breast cancer [27]. These tumor cells are able to cross the BBB and adhere to brain tissue. This process is

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• nanosized drug delivery carriers: Mixed-layer and multilayered nanocarriers with bioresponsive and cleavable layers, possessing different functional properties for improving the enhanced permeability and retention (EPR) effect, diffusion in the tumor microenvironment, cellular internalization and

• entire cardiac output, but successful lung localization of nanocarriers depends upon NP interaction with the endothelial cells. Lung endothelial cells are an important target for drugs and gene delivery as they are involved in processes such as inflammation, vascular permeability, and tumor growth. Also

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• efficiency (Figure 1). AB-LNPs also showed good stability under physiological conditions and demonstrated laser-responsive release characteristics (Figure 3). BDP grafted on the AB-LNPs could generate greatly enhanced cellular uptake in cancer cells (Figure 4). Due to the enhanced permeability and retention

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• to be compatible with the Peppas–Sahlin model. Within the scope of in vitro cytotoxicity studies, the drug-loaded NPs showed significantly higher cytotoxicity than a DCX solution on the HT-29 colon cell line, and CS/DCX-PLGA showed the highest cytotoxicity (p < 0.05). According to the permeability

• studies on the Caco-2 cell line, the CS/DCX-PLGA formulation increased permeability by 383% compared to free DCX (p < 0.05). In the light of all results, CS/DCX-PLGA NPs can offer a promising and innovative approach as an oral anticancer drug-loaded nanoformulation for intestinal tumors. Keywords

• treatment of colon tumors, to provide higher drug concentration in the tumoral region in the colon, to reduce systemic side effects compared to parenteral administrations, and to alleviate colon cancer. In vitro characterization, permeability studies, in vitro cell culture studies, and comprehensive release