Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• siRNA delivery should generally be positively charged to facilitate siRNA loading by electrostatic interactions. Frequently used traditional polymer materials as nonviral vectors for siRNA encapsulation are polyethyleneimine (PEI), cationic dendrimers, phospholipids, cationic lipids, polysaccharides

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• , Singen, Germany) at a frequency of 37 kHz in pure ethanol for 5 min. Subsequently, wafers were dried under a flow of nitrogen and covered with an 1% aqueous solution of branched polyethyleneimine (PEI), 25 kDa, for 15 min. To remove unbound PEI, the wafers were rinsed with deionized water. Coated wafers

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• chondrogenesis of MSCs and cartilage regeneration, which should be performed over a period of several days or weeks. However, a few of the proposed methods achieved the prolonged sustained release of bioactive molecules. For example, low molecular weight polyethyleneimine precoated poly(lactide-co-glycolide

• for growth factor delivery systems. In this regard, the complexation of cationic polymers such as Pluronic F68 [56], polyethyleneimine (PEI) [57], and poly-ʟ-lysine [58] with anionic heparin has been widely used to promote ionic interactions for the preparation of growth factor-loaded NPs. Heparin

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• selective uptake and hence the targeting ability of Erb-tagged nanoparticles. Altogether, this study proves luminescent, cationic, and small SPION@bPEI nanoparticles as strong candidates for imaging and gene therapy. Keywords: Erbitux; photoluminescence; polyethyleneimine; polyinosinic–polycytidylic acid

• limits their processability and hence medical use [13][14]. However, in recent years, amine-containing branched polymers such as polyethyleneimine (PEI) [15][16][17][18][19] and dendrimers such as polyamidoamine (PAMAM) [20][21][22][23][24] are reported as weakly blue luminescing organic materials. The

• recently due to a very weak luminescence. Lin et al. synthesized mostly linear PEI and demonstrated a siRNA delivery with this luminescent polymer [27]. Sun et al. utilized the luminescence of branched PEI as the imaging modality in polymeric quantum dots (PDOTs) formed from amphiphilic polyethyleneimine

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• . Polyethyleneimine (PEI, Mw = 600 Da) was purchased from Aladdin Chemistry Co., Ltd. Doxorubicin hydrochloride (DOX) was purchased from Dalian Meilun Biological Technology Co., Ltd (Dalian, China). Cell culture medium RPMI 1640, fetal bovine serum (FBS), penicillin/streptomycin solution and fluorescent Hoechst 33342

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• with polyethyleneimine and conjugated with CD44 siRNA can be used as non-viral gene therapy vectors. Polyethylene imine is the material of choice for nucleic acid intracellular delivery, as it gives a positive charge to the nanoparticle surface [41]. Polyvinyl alcohol (PVA)-coated SPIONs were tested as

• polyethyleneimine-coated SPIONs, which accumulated only in liver and spleen, with a maximum at 24 h [41]. Jain et al. [127] observed that 55% of the administered SPIONs were found in the liver after 6 h. They were gradually transformed to ferritin and hemosiderin, and then transferred to the spleen where they were

Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels

• Armel Boutchuen,
• Dell Zimmerman,
• Abdollah Arabshahi,
• John Melnyczuk and
• Soubantika Palchoudhury

Beilstein J. Nanotechnol. 2020, 11, 296–309, doi:10.3762/bjnano.11.22

• studying the flow of NPs. Iron oxide NPs are extensively investigated in targeted therapy and drug delivery applications owing to their tunable size, surface functionalities, and magnetic properties. In this study, we synthesized four different polyvinylpyrrolidone (PVP)/polyethyleneimine (PEI)-coated iron

• , 98%), sodium metabisulfite (Na2S2O5, NaMBS, Fisher, 99.4%), inhibitor remover (Sigma-Aldrich), iron(III)-2,4-pentanedionate (Fe(acac)3, Alfa Aesar), polyethyleneimine (PEI, Alfa Aesar, 60 kDa – 50 wt % aqueous solution), polyvinylpyrrolidone (PVP, TCI, 10 kDa, 99%), triethylene glycol (TREG, ACROS

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• polyethyleneimine coupled to β-carotene. After disassembly of the nanoparticles, the mean distance between pheophorbide a and β-carotene increases thus activating PDT. In an alternative strategy, aggregation-induced emission (AIE) fluorophores have been proposed as a solution to aggregation-induced quenching. These

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• a chitosan 3D scaffold and enhanced its bioactivity, mechanical properties, and pore formation with GO for optimal bone tissue engineering [15]. Zhang et al. improved the chemotherapy efficacy of anticancer drugs with polyethyleneimine (PEI)-grafted GO [16]. Liu et al. discussed the antibacterial

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

L-Lysine-grafted graphene oxide as an effective adsorbent for the removal of methylene blue and metal ions

• Yan Yan,
• Jie Li,
• Fangbei Kong,
• Kuankuan Jia,
• Shiyu He and
• Baorong Wang

Beilstein J. Nanotechnol. 2017, 8, 2680–2688, doi:10.3762/bjnano.8.268

• graphene oxide (GO) with malononitrile can increase the solubility in either organic or aqueous environments [21]. However, no practical application for the malononitrile-modified GO was described. Interestingly, Ma et al. reported an polyethyleneimine-functionalized ultra-light graphene aerogel (PFGA

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

• Olga Rotan,
• Katharina N. Severin,
• Simon Pöpsel,
• Alexander Peetsch,
• Melisa Merdanovic,
• Michael Ehrmann and
• Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

• polyethyleneimine (PEI; cationic nanoparticles) or carboxymethyl cellulose (CMC; anionic nanoparticles) and loaded with defined amounts of the fluorescently labelled proteins HTRA1, HTRA2, and BSA. The nanoparticles were purified by ultracentrifugation and characterized by dynamic light scattering and scanning

• substitution 0.7; 2 mg mL−1) or aqueous polyethyleneimine solution (PEI; Sigma-Aldrich, Mw = 25 kDa; 2 mg mL−1), respectively, to achieve the colloidal stability of the nanoparticle dispersion. These particles were used either as-prepared (denoted as CaP/CMC and CaP/PEI) or further loaded with proteins. For

• anionic and the particles functionalized with polyethyleneimine (PEI) were cationic. The concentration of calcium phosphate was computed from the calcium concentration as described in the experimental section. All concentrations refer to the nanoparticle stock solutions before the addition to the cell

Voltammetric determination of polyphenolic content in pomegranate juice using a poly(gallic acid)/multiwalled carbon nanotube modified electrode

• Refat Abdel-Hamid and
• Emad F. Newair

Beilstein J. Nanotechnol. 2016, 7, 1104–1112, doi:10.3762/bjnano.7.103

• with thionine and nickel hexacyanoferrate [13]. A polyethyleneimine-functionalized graphene oxide modified glassy carbon electrode sensor was developed for sensitive detection of gallic acid [14]. A polyepinephrine modified glassy carbon electrode electrochemical sensor was developed for adsorptive

Sandwich-like layer-by-layer assembly of gold nanoparticles with tunable SERS properties

• Zhicheng Liu,
• Lu Bai,
• Guizhe Zhao and
• Yaqing Liu

Beilstein J. Nanotechnol. 2016, 7, 1028–1032, doi:10.3762/bjnano.7.95

• alternating the adsorption of polyethyleneimine–silver ions and Au NPs onto substrates and the subsequent in situ reduction of the silver ions [17]. Compared with the parallel samples, the bimetallic LbL film showed improved SERS properties. Although a few examples of SERS substrates based on LbL strategy

Characterisation of thin films of graphene–surfactant composites produced through a novel semi-automated method

• Nik J. Walch,
• Alexei Nabok,
• Frank Davis and
• Séamus P. J. Higson

Beilstein J. Nanotechnol. 2016, 7, 209–219, doi:10.3762/bjnano.7.19

• LbL deposition of graphene(−)SDS alternated with polyethyleneimine (PEI). The optical study of graphene thin films deposited on different substrates was carried out using UV–vis absorption spectroscopy and spectroscopic ellipsometry. A particular focus was on studying graphene layers deposited on gold

• alternated with layers of polycationic species such as polyallylamine hydrochloride (PAH) or polyethyleneimine (PEI). Alternating layers of graphene(−)SDS and graphene(+)CTAB was also attempted. The films were deposited by consecutive dipping of gold-coated glass or silicon wafers into 1 mg·mL−1 solutions of

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• interactions with cells and proteins [12]. Biodegradable polymers that are generally used for coating magnetic nanoparticles include poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA), polyethyleneimine (PEI), poly(D,L-lactide), poly(lactic acid), poly(D,L-glycolide), poly(lactide-co-glycolide

From lithium to sodium: cell chemistry of room temperature sodium–air and sodium–sulfur batteries

• Philipp Adelhelm,
• Pascal Hartmann,
• Conrad L. Bender,
• Martin Busche,
• Christine Eufinger and
• Juergen Janek

Beilstein J. Nanotechnol. 2015, 6, 1016–1055, doi:10.3762/bjnano.6.105

Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells

• Nils Bohmer and
• Andreas Jordan

Beilstein J. Nanotechnol. 2015, 6, 167–176, doi:10.3762/bjnano.6.16

• of nanoparticles by HeLa cells is consistent with the literature. It was shown, that polyethyleneimine gold nanoparticles around 40 nm [33], gold nanoparticles of 4.5 nm [34] and conjugated polymer nanoparticles [36] are internalized through Caveolin dependent pathways. The same was observed for

Advances in NO₂ sensing with individual single-walled carbon nanotube transistors

• Kiran Chikkadi,
• Matthias Muoth,
• Cosmin Roman,
• Miroslav Haluska and
• Christofer Hierold

Beilstein J. Nanotechnol. 2014, 5, 2179–2191, doi:10.3762/bjnano.5.227

• SWNT FETs, for which the mechanisms may be different, is not available. On the other hand, polyethyleneimine (PEI) functionalization for NO2 sensing has been shown to dramatically enhance the response of SWNT sensors [14]. There, the authors argue that the main mechanism of sensitivity enhancement is

• -tube SWNT-based NO2 sensors. Sensors incorporating mats or forests of nanotubes are not considered. PEI: polyethyleneimine. It must be noted that the electrically refreshed gas sensors reported by Chang et al. [76] has been disputed by a subsequent article from Ervin et al. [77] who suggest that

Controlled synthesis and tunable properties of ultrathin silica nanotubes through spontaneous polycondensation on polyamine fibrils

• Jian-Jun Yuan,
• Pei-Xin Zhu,
• Daisuke Noda and
• Ren-Hua Jin

Beilstein J. Nanotechnol. 2013, 4, 793–804, doi:10.3762/bjnano.4.90

• crystalline fibrils that were conveniently produced from the neutralization of a solution of protonated linear polyethyleneimine (LPEI–H+) by alkali compounds. A simple mixing the fibrils with alkoxysilane in aqueous solution allowed for the rapid formation of silica to produce LPEI@silica hybrid nanotubes

• polymers and subsequent carbonization. Keywords: biomimetic silicification; polyethyleneimine; silica–carbon nanocomposite; silica nanotubes; template synthesis; Introduction Silica nanotubes with a controlled nanostructure (i.e., wall thickness and hollow space) and a tunable chemical composition are

• chemistry is highly desirable. We are interested in the programmable construction of biomimetic silica nanomaterials by exploiting the crystallization-driven self-assembly of a simple synthetic polyamine, namely linear polyethyleneimine (LPEI) [31][32][33]. In contrast to branched PEI, LPEI is composed only

Approaches to nanostructure control and functionalizations of polymer@silica hybrid nanograss generated by biomimetic silica mineralization on a self-assembled polyamine layer

• Jian-Jun Yuan and
• Ren-Hua Jin

Beilstein J. Nanotechnol. 2011, 2, 760–773, doi:10.3762/bjnano.2.84

• polyamine@silica nanoribbon-based hybrid nanograss film, which was generated by performing a biomimetic silica mineralization reaction on a nanostructured linear polyethyleneimine (LPEI) layer preorganized on the inner wall of a glass tube. We found that the film thickness, size and density of the

• and facilely functionalized makes our nanograss potentially important for device-based application in microfluidic, microreactor and biomedical fields. Keywords: biomimetic silica mineralization; linear polyethyleneimine; nanofiber; nanograss; thin film; Introduction Silica-based, one-dimensional

• controlled synthesis of silica or hybrid thin films with tunable one-dimensional nanostructures still remains a challenge [20][21][22][23][24][25][26]. We are interested in using crystalline, self-assembling linear polyethyleneimine (LPEI) [27] as a mediator for silica deposition under ambient conditions. As