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Search for "transporter" in Full Text gives 20 result(s) in Beilstein Journal of Nanotechnology.

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

  • Jonathan-Gabriel Nimz,
  • Pichayut Rerkshanandana,
  • Chiraphat Kloypan,
  • Ulrich Kalus,
  • Saranya Chaiwaree,
  • Axel Pruß,
  • Radostina Georgieva,
  • Yu Xiong and
  • Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

Graphical Abstract
  • ]. For decades, science has been trying to overcome these problems [6]. Although erythrocytes also pose as a CO2 transporter and native hemoglobin as a buffer system [7], research is being focused on their function as oxygen transporters. The search is on for a laboratory-produced oxygen carrier that is
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Published 19 Oct 2023

Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes

  • Akeem Adeyemi Oladipo and
  • Faisal Suleiman Mustafa

Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26

Graphical Abstract
  • carrier separation, high photo-transporter mobility, appropriate physical and chemical properties, sufficient band alignment to meet the kinetic requirements of the target reaction, and anti-corrosion stability in reactive environments [18][19][20]. Figure 1 depicts the mechanism of the photocatalyst. In
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Published 03 Mar 2023

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

  • Nikola Geskovski,
  • Nadica Matevska-Geshkovska,
  • Simona Dimchevska Sazdovska,
  • Marija Glavas Dodov,
  • Kristina Mladenovska and
  • Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

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Published 29 Apr 2021

Transient coating of γ-Fe2O3 nanoparticles with glutamate for its delivery to and removal from brain nerve terminals

  • Konstantin Paliienko,
  • Artem Pastukhov,
  • Michal Babič,
  • Daniel Horák,
  • Olga Vasylchenko and
  • Tatiana Borisova

Beilstein J. Nanotechnol. 2020, 11, 1381–1393, doi:10.3762/bjnano.11.122

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  • the formation of a protein biocorona from crucial proteins of the plasma membrane immediately after their addition to synaptosomes, which in turn disturbs activity and function of these proteins. In this context, nanoparticle-induced changes of the glutamate transporter function resulted in a decrease
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Published 10 Sep 2020

Key for crossing the BBB with nanoparticles: the rational design

  • Sonia M. Lombardo,
  • Marc Schneider,
  • Akif E. Türeli and
  • Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

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  • problem for drug delivery. Receptor-mediated transcytosis Endogenous molecules that do not have a specific transporter can also reach the brain through receptor-mediated transcytosis (RMT). It has been shown that RMT activity in brain endothelial cells is reduced compared to peripheral endothelial cells
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Published 04 Jun 2020

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

  • Anna V. Epanchintseva,
  • Julia E. Poletaeva,
  • Dmitrii V. Pyshnyi,
  • Elena I. Ryabchikova and
  • Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

Graphical Abstract
  • comparison, we presented the electropherogram of the initial bare gold nanoparticles (Figure 1G). The density of the siRNA molecules on the AuNP surface is an indicator of the efficiency of the nucleic acid transporter: the higher the density, the less amount of the preparation can be administered, thus
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Published 23 Dec 2019

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

  • Sebastian Pieper,
  • Hannah Onafuye,
  • Dennis Mulac,
  • Jindrich Cinatl Jr.,
  • Mark N. Wass,
  • Martin Michaelis and
  • Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

Graphical Abstract
  • . The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results
  • . To investigate whether easy-to-prepare nanoparticles made of well-tolerated polymers may circumvent transporter-mediated drug efflux, we prepared poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) nanoparticles loaded with the ABCB1 substrate doxorubicin by
  • carrier systems including PLA-, PLGA-, and PEG-based preparations have been reported to bypass the transporter-mediated efflux of anticancer drugs including doxorubicin [20][22][23][24][25][26][27][28][29][30][31]. However, there are also conflicting results from studies in which encapsulation of
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Published 29 Oct 2019

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

  • Hannah Onafuye,
  • Sebastian Pieper,
  • Dennis Mulac,
  • Jindrich Cinatl Jr.,
  • Mark N. Wass,
  • Klaus Langer and
  • Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

Graphical Abstract
  • body distribution of its many substrates including drugs, xenobiotics, and other molecules. HSA nanoparticles may provide an alternative, more specific way to overcome transporter-mediated resistance. Keywords: ABCB1; cancer; doxorubicin; drug resistance; human serum albumin; nanoparticles
  • ; transporter; Introduction According to Globocan there "were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide" [1]. Despite substantial improvements over recent decades, the prognosis for many cancer patients
  • important role in cancer cell drug resistance as a highly promiscuous transporter that mediates the cellular efflux of a wide range of structurally different substrates including many anticancer drugs. Different studies have reported that nanometer-sized drug carrier systems can bypass efflux-mediated drug
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Published 14 Aug 2019

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

  • Zdeněk Plichta,
  • Yulia Kozak,
  • Rostyslav Panchuk,
  • Viktoria Sokolova,
  • Matthias Epple,
  • Lesya Kobylinska,
  • Pavla Jendelová and
  • Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

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  • allows for a stable Dox concentration inside the cells, thus partially decreasing the effectiveness of ABC transporter proteins, which are responsible for drug efflux from the cytosol to the extracellular medium [24]. Other cell lines that are sensitive to chemotherapy (e.g., murine B16F10 melanoma
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Published 25 Sep 2018

Cr(VI) remediation from aqueous environment through modified-TiO2-mediated photocatalytic reduction

  • Rashmi Acharya,
  • Brundabana Naik and
  • Kulamani Parida

Beilstein J. Nanotechnol. 2018, 9, 1448–1470, doi:10.3762/bjnano.9.137

Graphical Abstract
  • semiconductors as they have good electron collector and transporter properties. These materials suppress the recombination of charge carriers by effectively transporting the photoinduced electrons of the semiconductor, resulting in high photocatalytic activity [111][112][113][114][115][116]. In addition to this
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Published 16 May 2018

Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

  • Liga Saulite,
  • Karlis Pleiko,
  • Ineta Popena,
  • Dominyka Dapkute,
  • Ricardas Rotomskis and
  • Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

Graphical Abstract
  • drug efflux transporter P-glycoprotein, which ensures rapid excretion of toxic substances from MSCs. Thus, MSCs are an excellent vector for low cytotoxicity anticancer drugs [4]. Sadhukha et al. demonstrated that nanoengineered MSCs home to A549 lung cancer in vivo and remain there for at least 3 h
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Published 29 Jan 2018

Two-dimensional carbon-based nanocomposites for photocatalytic energy generation and environmental remediation applications

  • Suneel Kumar,
  • Ashish Kumar,
  • Ashish Bahuguna,
  • Vipul Sharma and
  • Venkata Krishnan

Beilstein J. Nanotechnol. 2017, 8, 1571–1600, doi:10.3762/bjnano.8.159

Graphical Abstract
  • nanocomposites. Then, the development of various graphene-based nanocomposites for the above-mentioned applications is presented, wherein graphene plays different roles, including electron acceptor/transporter, cocatalyst, photocatalyst and photosensitizer. Subsequently, the development of different graphitic
  • , thermal, optical and mechanical properties, graphene helps to enhance the photocatalytic performance by acting as excellent electron acceptor and transporter in nanocomposites. Moreover, enhanced pollutant adsorption on the surface of graphene is an additional advantage, which accelerates the
  • water splitting reaction, the graphene in the nanocomposite plays different roles, such as photocatalyst, cocatalyst, electron acceptor/transporter and photosensitizer. These roles are described in detail in the following sections. Graphene as a photocatalyst A photocatalyst is a substance which
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Published 03 Aug 2017

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

  • Liga Saulite,
  • Dominyka Dapkute,
  • Karlis Pleiko,
  • Ineta Popena,
  • Simona Steponkiene,
  • Ricardas Rotomskis and
  • Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

Graphical Abstract
  • membrane transporters for the elimination of toxic reagents [53]. The induction of ABC transporter P-glycoprotein increases the elimination of QDs from HEK and HepG2 cells, while its inhibition demonstrated an opposite effect. The elimination rate was higher in HEK cells, because of the stem cell phenotype
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Published 07 Jun 2017

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

  • Bin Song,
  • Yanli Zhang,
  • Jia Liu,
  • Xiaoli Feng,
  • Ting Zhou and
  • Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

Graphical Abstract
  • affected by DNA methylation. DNA methylation was associated with expression of neurotransmitters. In an in vitro study, hypermethylation of the excitatory amino acid transporter (EAAT2) promoter in glioma cells led to a deficiency in astroglial EAAT2 expression, which was related to the pathogenesis of CNS
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Published 29 Apr 2016

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

  • Denise Bargheer,
  • Artur Giemsa,
  • Barbara Freund,
  • Markus Heine,
  • Christian Waurisch,
  • Gordon M. Stachowski,
  • Stephen G. Hickey,
  • Alexander Eychmüller,
  • Jörg Heeren and
  • Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 111–123, doi:10.3762/bjnano.6.11

Graphical Abstract
  • endosomal membrane by the divalent metal ion transporter, DMT1 [26]. During iron homeostasis, excess iron would then be released by, for example, macrophages via ferroportin, bound to apotransferrin and transported to cells in need for iron. The intracellular processing of Cr3+ is more or less unknown, and
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Published 09 Jan 2015

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

  • Yasuhiko Onishi,
  • Yuki Eshita,
  • Rui-Cheng Ji,
  • Masayasu Onishi,
  • Takashi Kobayashi,
  • Masaaki Mizuno,
  • Jun Yoshida and
  • Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

Graphical Abstract
  • complex removing it from the cell [47]. If the complex decomposes within a cell, just like any other drug carrier, naturally, DDMC/PTX will be also eliminated from the cell by the ABCB5 transporter, etc., as a resistance mechanism of melanoma cells to PTX. However, the intact DDMC/PTX complex has been
  • . [53] also showed that triterpenoid compounds such as corosolic acid isolated from apples, which activates the glucose transporter and suppresses the rise of blood glucose levels, inhibit the signal transduction factors related to the differentiation to M2 macrophages, namely, nuclear factor-kappa B
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Published 01 Dec 2014

In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

  • Wolfgang G. Kreyling,
  • Stefanie Fertsch-Gapp,
  • Martin Schäffler,
  • Blair D. Johnston,
  • Nadine Haberl,
  • Christian Pfeiffer,
  • Jörg Diendorf,
  • Carsten Schleh,
  • Stephanie Hirn,
  • Manuela Semmler-Behnke,
  • Matthias Epple and
  • Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

Graphical Abstract
  • proteins were identified on the three differently sized AuNP: 17 different proteins on the 5 nm AuNP, 17 on the 15 nm AuNP and 5 individual proteins on the 80 nm AuNP (Table 2). Proteins which were detected at least twice on each of all three differently sized AuNP were hemoglobin (oxygen transporter
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Published 02 Oct 2014

Nanostructure sensitization of transition metal oxides for visible-light photocatalysis

  • Hongjun Chen and
  • Lianzhou Wang

Beilstein J. Nanotechnol. 2014, 5, 696–710, doi:10.3762/bjnano.5.82

Graphical Abstract
  • , thus resulting in an enhanced photocatalytic activity. Apart from photosensitization, graphene also has other functionalities such as the role of an electron acceptor and transporter, a cocatalyst, and a photocatalyst in the field of hydrogen generation. Readers may refer to a recently published review
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Published 23 May 2014

Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone

  • Xiaohong Wang,
  • Heinz C. Schröder and
  • Werner E. G. Müller

Beilstein J. Nanotechnol. 2014, 5, 610–621, doi:10.3762/bjnano.5.72

Graphical Abstract
  • carbonic acid and finally undergoes precipitation to calcium carbonate. Bicarbonate is provided to the CA via the chloride/bicarbonate anion exchanger (AE), or by the sodium bicarbonate co-transporter (NBC). It is proposed that the calcium carbonate crystallites are formed in the vicinity of the plasma
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Published 12 May 2014

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

  • Pauline Maffre,
  • Karin Nienhaus,
  • Faheem Amin,
  • Wolfgang J. Parak and
  • G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

Graphical Abstract
  • cassette transporter A1 (ABCA1) [34]. In close vicinity to the larger patch, a small area of positive electrostatic potential is visible, which would be favorable for the interaction with our negatively charged NPs (red arrows in Figure 3b). By attaching with this patch to the NP surface, the apoA-I
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Published 12 Jul 2011
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