Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• healthy mice and in a murine model of Huntington's disease [42]. Similarly, inhalation for lung targeting [43], subcutaneous injection for reaching lymph nodes [44], or oral administration for gastrointestinal tract disorders [45] are important alternative routes. 4.2 Macrophage depletion and modulation

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

• characterisation reporting, its terminology, classification, and metadata. A standard structure containing this type of information relating to (i) materials characterisation (meta)data, termed CHADA (CHAracterisation DAta and description of a characterisation experiment), has recently been proposed [42

Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster

• Joel Antúnez-García,
• Roberto Núñez-González,
• Vitalii Petranovskii,
• H’Linh Hmok,
• Armando Reyes-Serrato,
• Fabian N. Murrieta-Rico,
• Mufei Xiao and
• Jonathan Zamora

Beilstein J. Nanotechnol. 2025, 16, 44–53, doi:10.3762/bjnano.16.5

• nanoparticles, sodium Linde A Type (LTA) zeolite, also known as NaA zeolite, stands out for its remarkable capacity and selectivity to capture various types of metals commonly found as contaminants in drinking water. These metals include Ca, K, Mg, Mn, Co, Zn, Cu, Pb, Cd, Cs, and Sr [42][43][44][45][46

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery

• Elina E. Mansurova,
• Andrey A. Maslennikov,
• Anna P. Lyubina,
• Alexandra D. Voloshina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Anzhela A. Mikhailova,
• Polina V. Mikshina,
• Albina Y. Ziganshina and
• Igor S. Antipin

Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2

• chloroform multiple times before being dried under reduced pressure at 80 °C for 2 h (Scheme 2). The yield is 0.42 g (42%). 1H NMR (600 MHz, D2O) δ 1.55 (br., 8H), 2.29 (br., 8H), 3.14 (br., 8H), 3.69 (br., 16H), 4.49 (br., 8H), 5.36 (br., 4H), 7.57 (br., 4H), 8.75 (br., 8H); 13C NMR (600 MHz, D2O) δ 151

Orientation-dependent photonic bandgaps in gold-dust weevil scales and their titania bioreplicates

• Norma Salvadores Farran,
• Limin Wang,
• Primoz Pirih and
• Bodo D. Wilts

Beilstein J. Nanotechnol. 2025, 16, 1–10, doi:10.3762/bjnano.16.1

• [40], 1.50–1.95 [41] and hybrid organotitania (1.75–2.05 [42], 1.55–1.65 [43]). This is lower than the tabulated values of titania prepared by, for example, layer deposition (2.10 [44], 2.40 [45], see also [46][47]), but higher than that of pure silica replicas (1.50 [18]). This is not unexpected as

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation

• Abhishek Das,
• Mangababu Akkanaboina,
• Jagannath Rathod,
• R. Sai Prasad Goud,
• Kanaka Ravi Kumar,
• Raghu C. Reddy,
• Ratheesh Ravendran,
• Katia Vutova,
• S. V. S. Nageswara Rao and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1639–1653, doi:10.3762/bjnano.15.129

• liquid exceeds the vapour pressure exerted by HfO2, the cavitation bubble collapses, and the vapour rushes through the liquid in the form of a jet [23][24][41]. The lower temperature of the surrounding liquid leads to the formation of nuclei [23][42][43] with random crystallographic orientation, which

• ; now DIA-CoE, University of Hyderabad), and the School of Chemistry for providing access to the necessary instruments. Funding Funding is provided by IOE, UoH, and ACRHEM/DRDO. Mangababu acknowledges financial support from CSIR India (for SRF) and IOE BHU (for RJP PDF). S.V.S Nageswara Rao DST PURSE

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• membrane vesicles are prepared, fusion with the nanocarrier can be accomplished by several methods [20][42]. Bath sonication disrupts membranes by forming cavitation bubbles, allowing them to reassemble around the nanocarrier. Optimizing this process requires adjusting exposure time, wave frequency, and

• enhance BBB penetration. Studies have shown that polymeric biomimetic nanoparticles carrying proteins can penetrate the brain parenchyma and release active agents, demonstrated by the increased accumulation of 3D6-Fab antibody fragments in the brains of mouse models, and reducing Aβ1-42 aggregation, which

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• allows one to maintain the original 3D ultrastructure of the samples without collapsing after dehydration [40][41]. When hydrated hydrogel-like CNFs are gently dried using CPD, the result is an aerogel-like material [41][42] with extremely interesting frictional properties [43]. The cell wall is a

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• hepatotoxicity and cause inflammatory reactions [31][40][41][42][43]. Askri et al. demonstrated the weakness of the antioxidant barrier against these iron nanoparticles [31]. When Fe3O4 NPs accumulate in lysosomes and release iron ions from their structure, this leads to the dysfunction of mitochondria

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• , sulfated polysaccharides and other biomolecules. The latter include flavonoids, alkaloids, steroids, phenols, and saponins with hydroxy, carboxyl, and amino functional groups, which are effective agents in metal reduction and also provide a robust coating on the metallic nanoparticles in a single step [42

Ultrablack color in velvet ant cuticle

• Vinicius Marques Lopez,
• Wencke Krings,
• Juliana Reis Machado,
• Stanislav Gorb and
• Rhainer Guillermo-Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122

• sunlight (personal observations). For subsequent analyses, we utilized female specimens collected from Caatinga regions in Pernambuco, Brazil (09°19’44.2’’S, 42°33’30’’W) in February 2022. The specimens were preserved in absolute alcohol. Scanning electron microscopy (SEM) To investigate the internal

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• benefits of this algorithm besides its robustness include resistance to overfitting and the ability to process datasets with numerous variables without the need of feature scaling [42]. This algorithm was implemented in Python, using scikit-learn package, a widely used library for ML models. Adaboost

• employed to identify and eliminate descriptors that contributed minimally to the model’s prediction accuracy. After this extensive parameter tuning, the optimal model was identified (128 estimators, maximum depth of five and random state equal to 42) as well as the optimal features (DLS, coating

Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection

• Thi Kim Ngan Nguyen,
• Tien Dat Doan,
• Huy Hieu Luu,
• Hoang Anh Nguyen,
• Thi Thu Ha Vu,
• Quang Hai Tran,
• Ha Tran Nguyen,
• Thanh Binh Dang,
• Thi Hai Yen Pham and
• Mai Ha Hoang

Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120

• )BTC@CPE were calculated to be 742, 1710, and 547 Ω, respectively. It is evident that CuBTC increased the Rct of the CuBTC@CPE electrode more than twofold compared to the CPE electrode, likely because of its low electron conductivity [41][42]. However, the addition of FeBTC, which has a low Rct of 220

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• technological questions into simulation and modelling workflows [42][43]. Additionally, these tools often come with pre-built databases, libraries, and visualization capabilities, further enhancing their usability and efficiency. In this work, we outline different aspects of data-intensive digital and

• expertise. Efforts to enhance the accessibility and affordability of HPC resources, along with user-friendly software interfaces, can help overcome these challenges [19][42][43]. Moreover, the integration of experimental and computational data presents a significant hurdle. Aligning experimental protocols

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• , prolongs their circulation time in the body, and enhances their therapeutic effectiveness [42][43]. Additionally, surface engineering of PLHNPs with different ligands facilitates specific delivery of drug/phytochemicals to desired tissues or cells, reduces their adverse effects, and improves their

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• comparison, in SiC, the energy of silicon vacancy migration is nearly 2.4 eV, and the energy of carbon vacancy migration is about 3.6 eV [42][43][44]. We focus on vacancy migration energies at the end of the paper and detail the findings. The surface energies σα and σβ of an iron-like nanoparticle are

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• ]. Although a successful experimental synthesis of ψ-graphene has not yet been realized, many theoretical investigations have been carried out by different research teams to study its various potential applications in sensors, lithium-ion batteries, and hydrogen storage [16][39][42]. We have recently employed

• an anode material in Li-ion batteries [16]. Theoretical investigations also suggest that when ψ-graphene is decorated with transition metals like zirconium, yttrium, and titanium, it can serve as an excellent adsorbent for hydrogen storage [42][44][45]. DFT calculations have shown that the adsorption

• energies of hydrogen molecules over Zr-, Y-, and Ti-decorated ψ-graphene are found to lie within the standard range of −0.2 to −0.7 eV specified by the Department of Energy (DoE) [42][44][45]. However, bandgap engineering, for example, passivation, doping, or strain engineering, is crucial to modify and

Ion-induced surface reactions and deposition from Pt(CO)₂Cl₂ and Pt(CO)₂Br₂

• Mohammed K. Abdel-Rahman,
• Patrick M. Eckhert,
• Atul Chaudhary,
• Johnathon M. Johnson,
• Jo-Chi Yu,
• Lisa McElwee-White and
• D. Howard Fairbrother

Beilstein J. Nanotechnol. 2024, 15, 1427–1439, doi:10.3762/bjnano.15.115

• emission, and physical sputtering of adsorbed or substrate atoms [21][22][25][31][36][37][38][39][40]. Ion-induced deposition can occur via a momentum/energy transfer process [21][25][41][42] that results in the decomposition of the precursor to form volatile species and an involatile deposit containing

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• potential as a next-generation photovoltaic technology [41][42]. These cells offer a compelling alternative to traditional silicon solar cells because of the low manufacturing cost. Additionally, CQDs possess a unique property – their bandgap can be tuned by adjusting the size of the dots. This allows them

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• action [41]. Intranasal delivery can be used to target a limitedly available site, the brain [42]. These N2B delivery applications are based on the olfactory region of the nasal cavity. Such N2B delivery applications exploit the direct anatomical connection between the brain and the olfactory region [43

• ]. N2B drug transport includes intracellular, paracellular, and extracellular mechanisms [42]. While the intracellular pathway is based on the drug’s internalization by the neurons followed by axonal transport, the extracellular pathway is based on the drugs’ transport through the paracellular space [61

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• shorter arms of ≈5 μm. The other tetrapods shown in Figure 3d, named T4, have pestle-like/cylindrical arms with unchanged diameter sizes of ≈800 nm, which were mixed with some multi-arm structures. According to the octa-twin model [42], the central nucleus is an octahedral multi-inversion twin that has

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• spectra (Figure 3b,d,f) yield peak envelopes made up of four distinct peaks. These four peaks from high to low binding energies, correspond to C–C/C–H bonds (285 eV), C=O bonds (288 eV), and two peaks related to fluorinated species (CF2 at 290.6 eV and CF3 at 293 eV) [28][42]. The C–C and C=O peaks likely

Out-of-plane polarization induces a picosecond photoresponse in rhombohedral stacked bilayer WSe₂

• Guixian Liu,
• Yufan Wang,
• Zhoujuan Xu,
• Zhouxiaosong Zeng,
• Lanyu Huang,
• Cuihuan Ge and
• Xiao Wang

Beilstein J. Nanotechnol. 2024, 15, 1362–1368, doi:10.3762/bjnano.15.109

• ][41][42]. Figure 2b shows the power-law relationship between photocurrent (Iph) and excitation power (P), Iph = P0.6, indicating that the photocurrent exhibits sublinear growth, consistent with the saturation effect. In Figure 2c, the TRPC measurement curve shows a symmetric dip at zero time delay

• absorption, graphene has been used to prepare high-speed photodetectors with intrinsic photocurrent response times down to the picosecond level [42]. Notably, under the same excitation conditions, comparison of the TRPC curves between the heterojunction and the graphene region in the heterojunction revealed

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• tiny structures belong to two main functional types. They are either mechanosensory and belong to the peripheral nervous system or they have no sensing role and serve to prevent wetting of, for example, wings and legs [41][42][43][44]. Other functions include the detection of airflow patterns, for