The impact of tris(pentafluorophenyl)borane hole transport layer doping on interfacial charge extraction and recombination

• Konstantinos Bidinakis and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2025, 16, 678–689, doi:10.3762/bjnano.16.52

• the core of their success lies the perovskite absorber material, which exhibits impressive bulk properties, such as long carrier lifetimes and low recombination rates [5][6][7][8]. However, the granular nature of perovskites and the layered structure of their solar cells, introduce complications such

• a complete understanding of the electric field difference plots (Figure 3), an analysis of their integrals which take into account both the peak heights and widths is required (see Supporting Information File 1, Section 7). Results show that the areas under the electric field peaks of the HTL side

Colloidal few layered graphene–tannic acid preserves the biocompatibility of periodontal ligament cells

• Teissir Ben Ammar,
• Naji Kharouf,
• Dominique Vautier,
• Housseinou Ba,
• Nivedita Sudheer,
• Philippe Lavalle and
• Vincent Ball

Beilstein J. Nanotechnol. 2025, 16, 664–677, doi:10.3762/bjnano.16.51

• microhardness without compromising biocompatibility [7]. In another work, the formulation of an injectable calcium phosphate cement–chitosan–graphene oxide (GO) composite was found to be effective. This composite fostered the proliferation of human dental pulp stem cells [8]. Despite these promising findings

• -DR, CD105, and CD11b [45]. The cells were cultured in a specialized medium (Gibco™ α-MEM, Thermo Fisher Scientific, Waltham, MA, USA) supplemented with 10% FBS and 1% penicillin–streptomycin (Dominique Dutscher, Bernolsheim, France). Cells from passages 3 to 7 were used for experiments. Metabolic

• test compounds [46]. Briefly, cells were seeded at a density of 1 × 105 cells/well (passages 3 to 7) in a 96-well plate with α-MEM essential medium supplemented with 10% FBS, 100 µg·mL−1 penicillin, and 100 µg·mL−1 streptomycin (Dutscher). The cells were treated with FLG and TA in fresh medium at

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

• Mazhar Hussain,
• Muhammad Farooq,
• Muhammad Asad Saeed,
• Muhammad Ijaz,
• Sherjeel Adnan,
• Zeeshan Masood,
• Muhammad Waqas,
• Wafa Ishaq and
• Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

• plasma (Cmax) is reached after approx. 4 h, and the half-life is 9–13 h. An oral dose of 125 mg APT one hour before chemotherapy treatment (day 1), and 80 mg daily in the morning on days 2 and 3 are recommended [7]. APT is strongly bound to plasma protein (95%); it is absorbed slowly and crosses the

• . Stability studies For stability studies, the optimal sample APT-CD-NP4 was used. The samples were exposed to 40 °C/75% RH for 0, 1, 2, 3, and 6 months. Figure 7 shows the XRD patterns of the corresponding samples. Freshly prepared APT-CD-NP4 showed peaks at 2θ values of 6.95° (270), 7.4° (290), and 32.1

• ° (244) (Figure 7a). After one and two months, peaks at 2θ values of 26.0° (227), 32.0° (257), and 31.8° (256) were measured (Figure 7b,c). After three and six months, peaks at 2θ values of 13.75° (446) and 13.0° (488) are seen (Figure 7d,e). Figure 7 shows that the peak intensity of APT in APT-CD-NP4 is

Nanoscale capacitance spectroscopy based on multifrequency electrostatic force microscopy

• Pascal N. Rohrbeck,
• Lukas D. Cavar,
• Franjo Weber,
• Peter G. Reichel,
• Mara Niebling and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2025, 16, 637–651, doi:10.3762/bjnano.16.49

• of Mainz, Staudingerweg 7, 55128 Mainz, Germany Institute for Photovoltaics, University of Stuttgart, Pfaffenwaldring 47, 70569 Stuttgart, Germany 10.3762/bjnano.16.49 Abstract We present multifrequency heterodyne electrostatic force microscopy (MFH-EFM) as a novel electrostatic force microscopy

• , in microelectronic devices, high-κ dielectric materials such as HfO2 and ZrO2 are critical for minimizing leakage currents and enhancing gate capacitance in transistors [7][8][9]. In energy storage systems, the dielectric constants of polymer–ceramic composites determine the efficiency and

• = VAC,2 = , Equation 7 can be rearranged as Thus, the waveform can be viewed as a high-frequency oscillation at (ωe,1 + ωe,2)/2 = ωmod/2 with a low-frequency amplitude modulation at frequency (ωe,1 − ωe,2)/2 = Δωe/2. This effect is also known as “beating” and is utilized in the AFM context for example

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• antidyslipidemic properties in vivo [4][5][6]. EOs are volatile components that are sensitive to temperature, light, oxygen, and humidity [7]. Therefore, it is recommended to use them in drug delivery systems, such as nanostructured systems, which are able to guarantee stability and a better therapeutic effect

• and one NTS were also obtained. Among the TLS, point 7 (M7-EOCF) was selected for subsequent tests, as it had the lowest amount of surfactants and the highest proportion of water in its composition. Physicochemical characterization of the selected system Some parameters are fundamental for

• Figure 7 shows that exposure of rats to STZ induced significant metabolic lipid disturbances. In the control group of diabetic rats, there was a considerable increase in plasma concentrations of total cholesterol (TC = 128.33 mg/dL), triglycerides (TG = 119.22 mg/dL), and low-density lipoprotein (LDL

Focused ion and electron beams for synthesis and characterization of nanomaterials

• Aleksandra Szkudlarek

Beilstein J. Nanotechnol. 2025, 16, 613–616, doi:10.3762/bjnano.16.47

• tetracarbonyl methyl acrylate (Fe(CO)4MA)) is studied in the gas phase using mass spectrometry and during electron-induced processes [7][8]. This issue also presents insights from initial studies using the novel (hfac)AgPMe3 precursor [9], which notably demonstrates a high level of purity at the interface with

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• of clarity never before possible [6][7]. In nanotechnology, different nanofiber production techniques are used such as template synthesis, electrospinning, solution blowing, drawing, thermally induced phase segregation, and self-assembly [8][9]. Among these techniques, electrospinning is the most

Feasibility analysis of carbon nanofiber synthesis and morphology control using a LPG premixed flame

• Iftikhar Rahman Bishal,
• Muhammad Hilmi Ibrahim,
• Norikhwan Hamzah,
• Mohd Zamri Mohd Yusop,
• Faizuan Bin Abdullah,
• I Putu Tedy Indrayana and
• Mohd Fairus Mohd Yasin

Beilstein J. Nanotechnol. 2025, 16, 581–590, doi:10.3762/bjnano.16.45

• delivery, tissue engineering, and implants [7]. Methods of CNT/CNF synthesis include (a) chemical vapor deposition, (b) arc discharge, (c) flame synthesis, and (d) laser ablation [1]. Flame-assisted synthesis is a promising method for efficient and continuous one-step production. Various flame

• the beads. As the equivalence ratio increased, a visible black layer formed on the beads, as shown in Figure 6b. The deposited CNFs were extracted from the beads using ex situ collection with a fluidized bed, and the black CNF powder was used for further characterization. The FESEM images in Figure 7

• equivalence ratio of 1.80. As expected, there is large number of CNFs present in the sample, as shown in Figure 8. The fraction of amorphous carbon in this sample is much smaller than that in Figure 7. The flame at 1.80 equivalence ratio ensures a suitable environment for carbon deposition. At higher fuel

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• aggregation linked to AD [6]. Additionally, the presence of the APOE4 genotype is notable, as it is found in approximately 65% of AD patients [5]. This genotype is associated with an increased tendency for amyloid monomers to aggregate into AβOs, potentially contributing to the pathology of the disease [7

Retrieval of B1 phase from high-pressure B2 phase for CdO nanoparticles by electronic excitations in Cd_xZn_1−xO composite thin films

• Arkaprava Das,
• Marcin Zając and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2025, 16, 551–560, doi:10.3762/bjnano.16.43

• and gamma radiation can induce lattice defects and lower the device efficiency [7]. Swift heavy ion (SHI) irradiation experiments provide valuable insights into the radiation stability of the transformed B2 phase, which is essential for the future utilization of these composite materials in space

• -based optoelectronic applications [7]. High-energy ion irradiation can lead to latent track formation or phase transitions, either from crystalline to crystalline or crystalline to amorphous, depending on the threshold electronic energy loss (Seth) [8][9]. The formation of latent tracks has been

• investigation, we primarily focus on Se, given the high energy of the irradiation ions (several MeV), while Sn becomes more significant in the keV range [7]. Here, we report on the radiation stability of the transformed B2 phase under 120 MeV Ag and 80 MeV O ion irradiation. Notably, such an investigation has

Functionalized gold nanoflowers on carbon screen-printed electrodes: an electrochemical platform for biosensing hemagglutinin protein of influenza A H1N1 virus

• Carlos Enrique Torres-Méndez,
• Sharmilee Nandi,
• Klara Martinovic,
• Patrizia Kühne,
• Yifan Liu,
• Sam Taylor,
• Maria Lysandrou,
• Maria Ines Berrojo Romeyro Mascarenhas,
• Viktoria Langwallner,
• Javier Enrique Sebastián Alonso,
• Ivana Jovanovic,
• Maike Lüftner,
• Georgia-Vasiliki Gkountana,
• David Bern,
• Abdul-Raouf Atif,
• Ehsan Manouchehri Doulabi,
• Gemma Mestres and
• Masood Kamali-Moghaddam

Beilstein J. Nanotechnol. 2025, 16, 540–550, doi:10.3762/bjnano.16.42

• generate measurable signals that reflect the concentration of the analyte [7]. Among different types of biosensors, electrochemical biosensors are particularly advantageous, since they can be built from low-cost components, designed to be compact and portable, while preserving high resolution, accuracy

Electron beam-based direct writing of nanostructures using a palladium β-ketoesterate complex

• Chinmai Sai Jureddy,
• Krzysztof Maćkosz,
• Aleksandra Butrymowicz-Kubiak,
• Iwona B. Szymańska,
• Patrik Hoffmann and
• Ivo Utke

Beilstein J. Nanotechnol. 2025, 16, 530–539, doi:10.3762/bjnano.16.41

• use of masks, achieving scales down to a few nanometers with various patterns and shapes, offers significant advantages for a wide range of technological applications. These include areas that require plasmonic [1][2][3], phononic [3][4], magnetic [5][6], optoelectronic [7][8][9], and mechanical [10

Zeolite materials with Ni and Co: synthesis and catalytic potential in the selective hydrogenation of citral

• Inocente Rodríguez-Iznaga,
• Yailen Costa Marrero,
• Tania Farias Piñeira,
• Céline Fontaine,
• Lexane Paget,
• Beatriz Concepción Rosabal,
• Arbelio Penton Madrigal,
• Vitalii Petranovskii and
• Gwendoline Lafaye

Beilstein J. Nanotechnol. 2025, 16, 520–529, doi:10.3762/bjnano.16.40

• systems enables the creation of materials with enhanced properties compared to monocationic zeolites, which is crucial for the development of advanced catalysts and other materials [7][8][9][10]. Natural zeolites attract significant attention because of their abundance, low cost, non-toxic nature, and

Water in nanoporous hexagonal boron nitride nanosheets: a first-principles study

• Juliana A. Gonçalves,
• Ronaldo J. C. Batista and
• Marcia C. Barbosa

Beilstein J. Nanotechnol. 2025, 16, 510–519, doi:10.3762/bjnano.16.39

• improve the desalination process. In pursuit of greater efficiency in the desalination process, the scientific community has proposed membranes composed of various materials, including graphene [7][8][9][10], carbon nanotubes [11][12][13][14], molybdenum disulfide (MoS2) [15][16][17][18], and hexagonal

• interaction between water and pores is the ability of a single water molecule to induce wrinkles in h-BN nanosheets with triangular pores, even when the pore is stabilized with B–H pairs at its vertices (see Figure 7). This deformation disappears upon removal of the water molecule. The observed deformation

N₂⁺-implantation-induced tailoring of structural, morphological, optical, and electrical characteristics of sputtered molybdenum thin films

• Usha Rani,
• Kafi Devi,
• Divya Gupta and
• Sanjeev Aggarwal

Beilstein J. Nanotechnol. 2025, 16, 495–509, doi:10.3762/bjnano.16.38

• substrates under suitable conditions lead to improvements in functionality and address the needs of various cutting-edge industries [6][7]. For the deposition of Mo thin films, various techniques such as chemical vapor deposition, physical vapor deposition (RF sputtering and DC sputtering) [1][8][9], and

• to a base pressure of 2.0 × 10−3 mbar, with a working pressure during deposition of approximately 1.2 × 10−2 mbar; deposition times varied from 7 to 12 min, resulting in films with thicknesses from 150 to 300 nm, as measured by spectroscopic ellipsometry. After deposition, some films with different

• curves derived from the fit process validate the results and offer a theoretical framework for understanding the optical properties of molybdenum thin films. Absorbance spectra The absorption spectra of Mo thin films in Figure 7 show the effects of nitrogen ion implantation and film thickness on the

Performance optimization of a microwave-coupled plasma-based ultralow-energy ECR ion source for silicon nanostructuring

• Joy Mukherjee,
• Safiul Alam Mollick,
• Tanmoy Basu and
• Tapobrata Som

Beilstein J. Nanotechnol. 2025, 16, 484–494, doi:10.3762/bjnano.16.37

• treatments such as nanopatterning, sputter etching, and controlled defect formation [6][7]. Particularly, ultralow-energy ion beams are exceptionally valuable for the precise modification of 2D layers [8] and ion-induced nanopatterning of semiconductor surfaces [9]. Over the past few decades, ion-induced

• formation of well-defined parallel ripples at off-normal incidence. Figure 7 illustrates the surface topography after 450 eV Ar-ion bombardment of the silicon surface at an angle of 72.5° as function of the bombardment time. 3D AFM images are presented along with 2D surface topography images. Generally, the

Impact of adsorbate–substrate interaction on nanostructured thin films growth during low-pressure condensation

• Alina V. Dvornichenko,
• Vasyl O. Kharchenko and
• Dmitrii O. Kharchenko

Beilstein J. Nanotechnol. 2025, 16, 473–483, doi:10.3762/bjnano.16.36

• ], sensors [5], and catalysts [6][7][8]. Nanostructured thin films grown via low-pressure deposition methods have garnered significant attention because of their diverse applications in electronics, optics, catalysis, and sensors [9]. The ability to precisely control properties such as morphology

• significantly within the interaction radius, we can exploit a self-consistent approximation used in different areas of numerical modeling [33][34][36][37][38][39]: Substituting Equation 7 into Equation 8 and assuming at m ≥ 2, the interaction potential of the adsorbate Uads(r) obtains the following form: Uads

• in elastic interaction strength δ. In Figure 7, we show snapshots of the typical surface morphology realized during deposition at different δ for different values of the adsorption rate α. It is seen that in the case of α = 0.04 (see Figure 7a), without elastic interactions between adsorbate and

Effect of additives on the synthesis efficiency of nanoparticles by laser-induced reduction

• Rikuto Kuroda,
• Takahiro Nakamura,
• Hideki Ina and
• Shuhei Shibata

Beilstein J. Nanotechnol. 2025, 16, 464–472, doi:10.3762/bjnano.16.35

• including electrode materials [1], conductive pastes [2][3], catalysts [4][5], sensors [6][7][8], and drug delivery systems [9]. The chemical reduction [10] and the solvothermal methods [11][12] are well known for synthesizing nanoparticles in large quantities at low cost, but these methods require the use

• for the radicals generated by laser irradiation in the solution. Methods Nanoparticles were synthesized by focusing and irradiating femtosecond laser pulses (Ti:sapphire laser, pulse width = 100 fs, pulse energy = 7 mJ, repetition rate = 1,000 Hz) on a precursor salt solution in a 3 mL fused silica

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• oncological, autoimmune, and infectious conditions, where genetic expression plays a crucial role on the disease pathogenesis and prognosis [1][2][3][4]. In the past decades, several approaches including cell-based therapies [5][6][7], gene therapies [8][9], and RNA therapies [10][11] have been studied to

• latter ssASO drug contains 2′-O-2-methoxyethyl modifications, which allow for the inclusion of exon 7 in the gene SMN2. This promotes the production of SMN protein, ameliorating the symptoms of spinal muscular atrophy [40]. ASO-based therapeutics have demonstrated great potential in the expansion of

• model of laser-induced choroidal neovascularization (CNV) showed that specific dendrimer/ODN-1 complexes, particularly those formed with dendrimers 4 and 7, significantly inhibited CNV development, reducing the severity of vascular leakage for up to two months. Similarly, Eom et al. presented an

Quantification of lead through rod-shaped silver-doped zinc oxide nanoparticles using an electrochemical approach

• Ravinder Lamba,
• Gaurav Bhanjana,
• Neeraj Dilbaghi,
• Vivek Gupta and
• Sandeep Kumar

Beilstein J. Nanotechnol. 2025, 16, 422–434, doi:10.3762/bjnano.16.33

• chemical substances [7][8]. Target detection in real time is a strong suit for electrochemical devices. Electron mediators are typically used to modify the working electrodes in electrochemical sensor fabrication. These days, due to their unique electrical and optical characteristics, nanomaterials are

• , environmental impact, can cause electrode corrosion, enhances interference, and is incompatible with real-life or biological samples. Therefore, PBS with pH 7 has been used for electrochemical studies since it provides a stable pH, which is crucial for maintaining consistent electrochemical conditions during

Biomimetics and bioinspired surfaces: from nature to theory and applications

• Rhainer Guillermo Ferreira,
• Thies H. Büscher,
• Manuela Rebora,
• Poramate Manoonpong,
• Zhendong Dai and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2025, 16, 418–421, doi:10.3762/bjnano.16.32

• mammals while addressing the functional fibrillar interfaces in biological hair. Presenting one applied example for biomimetic approaches, Ali et al. [7] used the hydrophobicity of the integument of spring tail (Collembola) as a template for the bioinspired development of nanofilament coatings that reduce

Size control of nanoparticles synthesized by pulsed laser ablation in liquids using donut-shaped beams

• Abdel Rahman Altakroury,
• Oleksandr Gatsa,
• Farbod Riahi,
• Zongwen Fu,
• Miroslava Flimelová,
• Andrei Samokhvalov,
• Stephan Barcikowski,
• Carlos Doñate-Buendía,
• Alexander V. Bulgakov and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 407–417, doi:10.3762/bjnano.16.31

• nanoparticles (NPs) with defined particle sizes and narrow size distribution width is driven by the growing integration of nanomaterials into various industrial applications, such as medicine [1][2][3], catalysis [4][5], sensors [6][7], and additive manufacturing [8]. The performance of NPs typically depends on

• distance between the target surface and the window was ca. 7 mm. Deionized water was used as liquid in all experiments and pumped through the chamber at a flow rate of 0.13 L·min−1, ensuring the complete filling of the chamber volume under laminar flow conditions. For the synthesis of gold and Y2O3 NPs

• acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), grant numbers GO 2566/8-1, GO 2566/14-1, GO 2566/7-2 (428315411). The authors further thank the DFG and NRW for funding in the frame of the major equipment program (INST 20876/212-1). Carlos Doñate Buendia thanks

ReactorAFM/STM – dynamic reactions on surfaces at elevated temperature and atmospheric pressure

• Tycho Roorda,
• Hamed Achour,
• Matthijs A. van Spronsen,
• Marta E. Cañas-Ventura,
• Sander B. Roobol,
• Willem Onderwaater,
• Mirthe Bergman,
• Peter van der Tuijn,
• Gertjan van Baarle,
• Johan W. Bakker,
• Joost W. M. Frenken and
• Irene M. N. Groot

Beilstein J. Nanotechnol. 2025, 16, 397–406, doi:10.3762/bjnano.16.30

• these techniques are photon-based [4][5][6][7][8][9]. Even though they provide valuable insights, the development of surface-sensitive techniques that can image the catalyst at the atomic scale under high-pressure and high-temperature conditions remains crucial. In attempting to close the pressure gap

• current of 6 mA, and beam energy of 2 kV for 7 min. Figure 6a shows an AFM image at room temperature and high vacuum (≈10−7 mbar) of the prepared surface in the closed reactor. The Co nanoparticles appear as bright dots on the surface with an average diameter of ≈20 nm. Figure 6b shows the surface at 430

• larger particle sizes. Despite not being able to image the surface during the FTS reaction at 550 K, it was possible to measure possible reaction products using QMS at higher temperatures, as shown in Figure 7. During the heating process, at around 490 K, we observe a strong increase in the counts of

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• , 190, 12, and 4 h of exposure, respectively [6]. The sub-lethal chronic effects of SDS were observed on the survival, metabolic processes, and development of juvenile Centropomus parallelus specimens exposed to the compound at three distinct salinity levels [7]. In vitro studies on bovine lenses at an

Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• positive charge. A peptide, as a model drug, was loaded onto the nanoparticles with an encapsulation efficiency of 58%. The release of the model drug from the delivery system was pH-independent and lasted for 7 days. The periodic acid–Schiff stain assay indicated 69% mucin interaction for the nanoparticles

• to the site of action because of increased drug retention at the mucosa [7]. These systems have the capacity to strongly adhere to the mucus layer, provide slow release of its contents, and even reduce the required dose because of higher accumulation of the drug at the target site [8]. Nanoparticles

• ± 3.9)%. To our knowledge, the range of encapsulation efficiency (EE) values determined in studies conducted with alginate-based nanoparticles was 7–90% [46][47]. As examples, Fernando et al., produced nanoparticles by a water-in-oil emulsification/external gelation process with EE values of 36% [48