The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde

  1. Volodymyr V. Tkachenko1,2,
  2. Elena A. Muravyova1,
  3. Sergey M. Desenko1,2,
  4. Oleg V. Shishkin1,2,
  5. Svetlana V. Shishkina1,
  6. Dmytro O. Sysoiev3,
  7. Thomas J. J. Müller4 and
  8. Valentin A. Chebanov1,2,4

1Division of Chemistry of Functional Materials, SSI “Institute for Single Crystals” NAS of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine
2Faculty of Chemistry, V. N. Karazin Kharkiv National University, Svobody sq. 4, Kharkiv 61022, Ukraine
3Fachbereich Chemie, University of Konstanz, Fach M-720, Universitaetsstrasse 10, D-78457 Konstanz, Germany

4Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany

  1. Corresponding author email

This article is part of the Thematic Series "Multicomponent reactions II".

Associate Editor: P. R. Hanson
Beilstein J. Org. Chem. 2014, 10, 3019–3030. doi:10.3762/bjoc.10.320
Received 15 Oct 2014, Accepted 03 Dec 2014, Published 17 Dec 2014


The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selectively obtain two or three types of heterocyclic scaffolds depending on the substituent in the N-aryl moiety.

Keywords: 5-amino-3-methylisoxazole; catalysis; chemoselectivity; heterocycle; multicomponent reaction; ultrasonication; salicylaldehyde


Generally, considerable interest in heterocyclic compounds is due to their key role in biological processes in nature and biological activity. In particular, condensed heterocycles bearing a hydroxyaryl group as well as tricyclic nitrogen-containing heterocycles derived from salicylaldehyde have been reported as anticancer [1], antihypertensive agents [2], neuropeptide Y antagonists [3], and calcium channel blockers [4]. Fused azoloazines containing carboxamide substituents also exhibit a broad spectrum of biological activity [5,6], which led to choose acetoacetamides as perspective methylene-active compounds for further studies of multicomponent reactions.

The interactions of 3-oxobutanamides with aldehydes and a number of aminoazoles, namely 3-amino-1,2,4-triazoles [7-11], 5-aminotetrazole [9], 5-aminopyrazoles [11], and 5-amino-1,2,3-triazole [12] have previously been investigated. In some cases when the reaction could proceed in two alternative pathways the conditions enabling to control the interaction direction were determined, which made it possible to obtain the desired azoloazine with high chemo- and regioselectivity [11,13-15]. In particular, three-component heterocyclizations involving 3-amino-1,2,4-triazoles or 4-substituted 5-aminopyrazoles yielded either 4,5,6,7-tetrahydroazolo[1,5-a]pyrimidine-6-carboxamides under ultrasonication at room temperature (kinetic control) or 4,7-dihydroazolo[1,5-a]pyrimidine-6-carboxamides at reflux in an applicable solvent (thermodynamic control), respectively (Scheme 1). The behavior of the reaction of 5-aminopyrazoles containing substituents in the position 3 is influenced by the structure of aminoazoles and aldehydes, giving rise either to pyrazolopyridine or pyrazolopyrimidine heterocycles. In the authors' opinion, the different outcomes in three-component reactions involving 3-methyl- or 3-aryl-substituted 5-aminopyrazoles can mainly be put down to the steric substituent effect [11].


Scheme 1: Some three-component reactions involving N-aryl-3-oxobutanamides.

It is noteworthy to mention that studies on multicomponent heterocyclizations involving different N-containing polynucleophiles and salicylaldehyde are of particular interest due to the bifunctional reactivity of the latter component. The presence of both electrophilic and nucleophilic reaction centers in salicylaldehyde enables condensations to proceed in various possible directions. The direction control would open pathways for selectively obtaining different classes of heterocyclic compounds [16-20]. Simultaneously, the selectivity will inevitably be dictated by the variation of the reaction conditions [17,18].

Thus, Světlik et al. studied the Biginelli-type condensation of 2-hydroxybenzaldehyde with urea (thiourea) and dialkyl acetone-1,3-dicarboxylates as active methylene components [16]. Unexpectedly, the reaction with salicylaldehyde furnished two different products depending on the ester alkyl group (Scheme 2). Obtaining of two classes of compounds was found to originate from steric influence rendered by the alkyl moiety of the ester group in the active methylene species. Inspired by Světlik’s studies, Jing et al. [17] developed an efficient method for the synthesis of oxygen-bridged pyrimidine tricyclic derivatives from salicylaldehyde, various dicarbonyl compounds, and urea (thiourea) using PdO as a catalyst (Scheme 2).


Scheme 2: Some Biginelli-type three-component condensations with salicylaldehyde.

Heterocyclizations involving both, salicylaldehyde and aminoazoles, are intriguing as well. Thus, for example in the course of the study on the application of 3-amino-1,2,4-triazole and salicylaldehydes in a Biginelli-like three-component condensation, two alternative outcomes were observed by Gorobets et al. [18]. When the condensation with acetone was performed in methanol with catalytic amounts of HCl under reflux conditions, a tetrahydrotriazolo[1,5-a]pyrimidine derivative was obtained, while under microwave irradiation the substituted oxygen-bridged triazolo[1,5-c][1,3,5]benzoxadiazocine was formed (Scheme 2).

Interesting results were also described by Světlik and Kettmann [19]. In the case of a three-component interaction of aminoazole, salicylaldehyde, and methyl acetoacetate in refluxing ethanol in the presence of hydrochloric acid, instead of oxygen-bridged compounds oxadiazaspiranes were isolated. On the other hand, Umarov and coworkers [20] have synthesized by condensation of 5-ethyl-1,3,4-thiadiazol-2-amine, salicylaldehyde, and pentane-2,4-dione in refluxing ethanol a representative of another heterocyclic class, namely thiadiazolylaminochromane.

Here we disclose our recent findings of three-component heterocyclizations involving 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides that were found to differ from similar reactions of cyclic CH acids [13].

Results and Discussion

The three-component heterocyclization of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-(2-methoxyphenyl)-3-oxobutanamide (3a) was chosen as a model reaction which was studied by variation of the reaction conditions. First, at room temperature under mechanical stirring for 48 h the reaction proceeded to form mainly two compounds – Knoevenagel adduct 7 and Schiff base 8 (Scheme 3). Trace amounts of 2-hydroxy-N-(2-methoxyphenyl)-2-methyl-4-(3-methylisoxazol-5-ylamino)chroman-3-carboxamide (4a) were detected in the reaction mixture as well.


Scheme 3: Three-component heterocyclization of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-(2-methoxyphenyl)-3-oxobutanamide (3a).

Furthermore, both conventional and microwave heating did not produce any positive results. Thus, refluxing of the reactants in water, ethanol, dioxane, or application of microwave irradiation at temperatures up to 140 °C only gave rise to the formation of imine 8 (Scheme 3). The reaction time in these cases reached 3 h. On the other hand, refluxing in high boiling solvents (n-butanol, DMF, DMSO), as well as microwave irradiation at temperatures above 140 °C, resulted in resinification of the reaction mixture. The reaction times were varied from a minute (for microwave irradiation) to 40 min (for conventional heating).

Inter alia, ultrasonic activation was applied to promote this multicomponent reaction. It was established that the three-component cyclocondensation of the starting compounds under ultrasonication at room temperature for 4 h led to the selective formation of the substituted chroman-3-carboxamide 4a in 58% yield (Scheme 3). In contrast to the similar reaction involving derivatives of 1,3-cyclohexanedione [13], here the final product was formed with participation of the exocyclic NH2-group of aminoisoxazole but not with its 4-CH center that may be linked via different mechanisms (see below).

Next the effect of different catalysts on the reaction was studied. It should be noted that in the case of catalytic processes both conventional and microwave heating were also inefficacious. The only noteworthy result was the detection of trace amounts of 4-(2-hydroxyphenyl)-N-(2-methoxyphenyl)-3,6-dimethyl-4,7-dihydroisoxazolo[5,4-b]pyridine-5-carboxamide (5a) (Scheme 3) in the reaction mixture when the reaction was performed in n-butanol under conventional heating for 25 min using ytterbium or scandium triflate as the catalysts.

Then, it was established that the three-component heterocyclization of aminoisoxazole 1, salicylaldehyde (2) and acetoacetamide 3a in the presence of 5 mol % ytterbium triflate as a catalyst in ethanol under stirring at room temperature for 48 h led to the formation of the aforementioned dihydroisoxazolopyridine 5a in 69% yield.

To our surprise the analogous catalytic reaction in ethyl alcohol under ultrasonication at room temperature for 4 h gave exclusively N-(2-methoxyphenyl)-1,5-dimethyl-5,11-dihydro-4H-5,11-methanobenzo[g]isoxazolo[5,4-d][1,3]oxazocine-12-carboxamide (6a) in 66% yield (Scheme 3), while the absence of the isomeric heterocyclic compound 5a was proven by means of TLC and NMR spectroscopy. In all cases of three-component reactions involving aminoazoles and carbonyl compounds, which were previously studied in our group [13,18,21-24], the substitution of mechanical stirring by ultrasonication did not change the structure of the final products but only affected the purity and yields of the final compounds as well as the reaction rate.

Several Lewis and Brønsted acids have been scanned as catalysts for this reaction. The results of the catalyst system selection for this reaction under stirring at room temperature are summarized in Table 1 and Table 2. Ytterbium triflate (5 mol %) was identified as the catalyst of choice.

Table 1: Optimization of the reaction conditions for obtaining compound 5a.

Catalyst Catalyst amount (% of the stoichiometric) Product yield (%)
Sc(OTf)3 2 33
Sc(OTf)3 5 58
Sc(OTf)3 10 54
Sc(OTf)3 15 47
Yb(OTf)3 2 30
Yb(OTf)3 5 69
Yb(OTf)3 10 64
Yb(OTf)3 15 52
Al(O-iPr)3 10 15
Al(O-iPr)3 20 18
HCl 5 no product
(mixture resinification)
p-TsOH 2 no product
(mixture resinification)

Table 2: Optimization of the reaction conditions for heterocycle 6a synthesis.

Catalyst Catalyst amount (% of the stoichiometric) Product yield (%)
Sc(OTf)3 2 27
Sc(OTf)3 5 62
Sc(OTf)3 10 58
Sc(OTf)3 15 38
Yb(OTf)3 2 35
Yb(OTf)3 5 66
Yb(OTf)3 10 59
Yb(OTf)3 15 42
Al(O-iPr)3 10 no product
Al(O-iPr)3 20 15
HCl 5 no product
(mixture resinification)
p-TsOH 2 no product
(mixture resinification)

The next step of our study was to expand the range of N-aryl-3-oxobutanamides. First, it is worth mentioning that the three-component cyclocondensation of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-aryl-3-oxobutanamides 3ah under ultrasonication at room temperature for 4 h without catalyst always led to the selective formation of the corresponding chroman-3-carboxamides 4ah (Table 3, entries 1, 4, 7, 10, 13, 16, 19, 22).

Table 3: Three-component heterocyclization of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-aryl-3-oxobutanamides (3ah).

[Graphic 1]
Entry Amide Conditions Product Yield, %
1 [Graphic 2]
EtOH, ))), rt, 4 h [Graphic 3]
2   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 4]
3   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h [Graphic 5]
4 [Graphic 6]
EtOH, ))), rt, 4 h [Graphic 7]
5   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 8]
6   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   69
7 [Graphic 9]
EtOH, ))), rt, 4 h [Graphic 10]
8   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 11]
9   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h [Graphic 12]
10 [Graphic 13]
EtOH, ))), rt, 4 h [Graphic 14]
11   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 15]
12   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   65
13 [Graphic 16]
EtOH, ))), rt, 4 h [Graphic 17]
14   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 18]
15   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   81
16 [Graphic 19]
EtOH, ))), rt, 4 h [Graphic 20]
17   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 21]
18   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   75
19 [Graphic 22]
EtOH, ))), rt, 4 h [Graphic 23]
20   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 24]
21   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   82
22 [Graphic 25]
EtOH, ))), rt, 4 h [Graphic 26]
23   EtOH, Yb(OTf)3 (5 mol %), rt, 48 h [Graphic 27]
24   EtOH, Yb(OTf)3 (5 mol %), ))), rt, 4 h   63

However, to our surprise, the ytterbium triflate-catalyzed three-component reaction of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-phenyl-3-oxobutanamide (3b) gave rise to the formation of 4-(2-hydroxyphenyl)-3,6-dimethyl-N-phenyl-4,7-dihydroisoxazolo[5,4-b]pyridine-5-carboxamide (5b) both under stirring and under ultrasonication at room temperature (Table 3, entries 5, 6). The scope and limitations for this process was therefore studied.

It was shown that N-(2-ethoxyphenyl)-3-oxobutanamide (3c) behaved under all reaction conditions in the same way as N-(2-methoxyphenyl)-3-oxobutanamide (3a): the three-component heterocyclization in the presence of ytterbium triflate under stirring at room temperature led to the formation of dihydroisoxazolopyridine 5c (Table 3, entry 8) whereas the analogous reaction under ultrasonication gave exclusively the benzoxazocine derivative 6c (Table 3, entry 9).

Interestingly, such a product dichotomy in condensations under or without ultrasonication was not typical for the other studied N-aryl-3-oxobutanamides 3b,dh. By this way the 4,7-dihydroisoxazolo[5,4-b]pyridine-5-carboxamides 5b,d,h were obtained if the corresponding N-aryl-3-oxobutanamides contained either an ortho-hydroxy group in the benzene ring or no ortho-substituent (Table 3, entries 5, 6, 11, 12, 23, 24). On the other hand, N-aryl-4-(2-hydroxyphenyl)-3,6-dimethylisoxazolo[5,4-b]pyridine-5-carboxamides 9eg were allocated if the acetoacetamide had any non oxygen-containing ortho-substituent on the benzene ring (Table 3, entries 14, 15, 17, 18, 20, 21). It is worth mentioning that aromatic compounds 9eg were isolated in both aerobic and anaerobic (under inert argon atmosphere) conditions.

Based on these investigations we have proposed the structure of a feasible intermediate complex in the catalytic reactions leading to compounds 6 (Figure 1). This complex presumably facilitates a subsequent nucleophilic substitution of the salicylic hydroxy group leading to the oxygen-bridged heterocycle 6. Apparently the oxygen-containing ortho-substituent on the benzene ring adopts an important role in the central ion coordination.


Figure 1: The possible structure of an intermediate complex in reactions forming the heterocycles 6.

At first glance, the behavior of N-(2-hydroxyphenyl)-3-oxobutanamide (3h) in the three-component catalytic reaction with 5-amino-3-methylisoxazole (1) and salicylaldehyde (2) does not confirm this hypothesis since compound 6 was not observed in this case (Table 3, entries 23, 24). As one possible reason we assumed that the presence of an acidic phenol group – distinguishing the amide 3h from alkoxylated amides 3a,c – could be responsible for a destabilization of the aforementioned complex. Indeed, it was established that the three-component heterocyclizations of aminoisoxazole 1 with salicylaldehyde (2) and N-aryl-3-oxobutanamides 3a,c supplemented with ytterbium triflate as a catalyst in the presence of an equimolar amount of phenol (as a source of phenolic acidity) led to the formation of dihydroisoxazolopyridines 5a,c rather than benzoxazocines 6a,c thus supporting the assumptions.

A plausible mechanistic rationale is outlined in Scheme 4. It should be firstly noted that the formation of any of the compounds 46a through the intermediate 7 (pathway A) as for cyclic 1,3-diketones [13,25] was excluded because the latter does not react with amide 3a under any comparable conditions.


Scheme 4: Possible pathways for the three-component reaction of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-(2-methoxyphenyl)-3-oxobutanamide (3a).

Most likely the formation of chroman-3-carboxamide 4a proceeds through imine 8 (pathway B) since the reaction of 8 and 3a under ultrasonication at room temperature gave the corresponding final product essentially after the same reaction time.

The Lewis acid catalyst activates the carbonyl group in salicylaldehyde (2), which is subsequently able to interact with the 4-CH nucleophilic center of the aminoisoxazole 1 and not only with the exocyclic NH2 group [26]. The resulting adduct 10 (Scheme 4, pathway C) then reacts with carboxamide 3a forming intermediate 11 which can lose a water molecule in two different ways: either by elimination occurring at room temperature leading to dihydroisoxazolo[5,4-b]pyridine 5a or through nucleophilic substitution involving the phenolic hydroxy group under ultrasonic activation furnishing the oxygen-bridged compound 6a. Most likely, here the key influence of ultrasound is the transfer of energy to the reaction mixture that is required for intramolecular cyclization that cannot be received by standard mechanical stirring.

However, it cannot be excluded that the Lewis acid catalyzed process proceeds through a primary attack of the exocyclic NH2 group of aminoisoxazole to the activated β-carbonyl group of acetoacetamide and further reaction with the aldehyde, as it was described for analogous three-component reactions [27,28].

The structures of all synthesized compounds were unambiguously established by elemental analysis, MS, NMR spectroscopy and X-ray analysis. Thus, the 1H NMR spectrum of chroman-3-carboxamide 4a exhibits a singlet for the NH amide group at δ 9.25, a broad multiplet including peaks for the aromatic protons, a singlet for the OH group, and a doublet for the NH-isoxazole group around δ 6.70–7.84, a multiplet for the 4-CH-group at δ 4.90, a singlet for the CH-isoxazole group at δ 4.71, a doublet for the 3-CH-group at δ 2.94 as well as signals for the other terminal substituents. The relative stereochemistry of the stereogenic centers at positions 3 and 4 of compound 4a was established by 1D and 2D NMR spectra. Thus, a 3J coupling constant of 11.7 Hz accounts for a trans-orientation. The NOESY experiment showed only a quite weak interaction between these protons.

The spectral data obtained for dihydroisoxazolopyridine 5a may correspond to at least two possible isomers 5a and 5'a (Figure 2). The data from COSY and NOESY experiments showed correlations between protons of NH and CH3 groups in the dihydropyridine ring and no interactions between NH and CH groups or two CH3 groups supporting structure 5'a could be detected. All the data obtained from HMBC spectra also unambiguously support the connectivity of structure 5a but not of isomer 5'a.


Figure 2: Alternative structures 5a and 5'a for dihydroisoxazolopyridine 5a and selected NOESY correlations.

The spectra observed for compound 6a may correspond to at least three possible isomers 6a, 6'a, and 6''a (Figure 3). Assignment of the structure 6a was achieved with the help of 2D NMR experiments (Figure 4).


Figure 3: Alternative structures 6a, 6'a and 6''a for compound 6a.


Figure 4: Selected data from NOESY experiments and relative stereochemistry of stereogenic centers at positions 4 and 12.

COSY and NOESY spectra showed correlations between the protons of the NH and CH3 groups in the tetrahydropyridine ring which should be absent in case of structure 6''a. Neither scalar nor dipolar coupling between NH and CH groups were detected in these experiments which would be expected for structure 6'a. The data obtained from the HMBC spectrum also unambiguously supported the connectivity of structure 6a and not those of structures 6'a or 6''a.

The relative stereochemistry of the stereogenic centers at positions 4 and 12 of compound 6a was first established by analysis of the 1D and 2D NMR spectra. Thus, a 3J coupling constant of 1.9 Hz corresponds with a cis-orientation and the NOESY experiment additionally supports the proximity of this pair of protons.

The structure of compound 6a with relative stereochemistry of stereogenic centers was finally corroborated by an X-ray diffraction study (Figure 5). The heterocycles of the polycyclic fragment adopt a chair-like conformation (the puckering parameters [29] are: S = 0.78, Θ = 32.8°, Ψ = 1.0° and S = 0.83, Θ = 38.0°, Ψ = 1.8° for the tetrahydropyridine and dihydrooxine rings, respectively). Deviation of the C5 atom from the mean plane of the remaining atoms of the ring is 0.70 Å and −0.77 Å for these two rings.


Figure 5: Molecular structure of compound 6a according to X-ray diffraction data.


In summary, the three-component heterocyclizations involving 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides were studied in detail. Generally the reaction may be switched between two pathways leading to the formation of 4-(isoxazol-5-ylamino)chroman-3-carboxamides (ultrasonication at room temperature without catalysts) and isoxazolo[5,4-b]pyrimidine-5-carboxamides (ultrasonication or mechanical stirring at room temperature with Yb(OTf)3). However, an unexpected influence of the N-o-alkoxyaryl substituent in acetoacetamides on the outcome of the process under ultrasonication leading to the exclusive isolation of benzo[g]isoxazolo[5,4-d][1,3]oxazocine-12-carboxamides was additionally observed. The mechanistic rationale was developed on the basis of experiments with presumed intermediates and literature evidence.

Supporting Information

Supporting Information File 1: Experimental procedures, characterization data, 1H and 13C spectra for all new compounds.
Format: PDF Size: 2.8 MB Download


VAC was supported by DAAD scholarship. Authors thank to Dr. V. Musatov for help in recording some NMR spectra.


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