Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces

Scholarly Works

• Kaewkla, O.; Kiakhunthod, K.; Chookhampaeng, S.; Chutiman, N.; Klankeo, P.; Pachanakarn, N.; Franco, C. M. M. Streptomyces spp. as plant growth promotors and regulators of Eucalyptus under heat, drought and saline stress and genome insights into three selected strains. Frontiers in Agronomy 2025, 7. doi:10.3389/fagro.2025.1665930
• Liu, R.-Z.; Zhang, Z.; Li, M.; Zhang, L. A metabologenomics strategy for rapid discovery of polyketides derived from modular polyketide synthases. Chemical science 2025, 16, 1696–1706. doi:10.1039/d4sc04174g
• Romanenko, M. N.; Shikov, A. E.; Savina, I. A.; Shmatov, F. M.; Nizhnikov, A. A.; Antonets, K. S. Genomic Insights into the Bactericidal and Fungicidal Potential of Bacillus mycoides b12.3 Isolated in the Soil of Olkhon Island in Lake Baikal, Russia. Microorganisms 2024, 12, 2450. doi:10.3390/microorganisms12122450
• Huang, S.-S.; Yang, H.-X.; He, J.; Liu, J.-K.; Feng, T. Discovery of a Biocontrol Strain Trichaptum laricinum: Its Metabolites and Antifungal Activity against Pathogenic Fungus Colletotrichum anthrisci. Journal of agricultural and food chemistry 2024, 72, 13154–13163. doi:10.1021/acs.jafc.4c02028
• Kawicha, P.; Nitayaros, J.; Sangdee, K.; Thanyasiriwat, T.; Somtrakoon, K.; Sangdee, A. Genomic insights into Streptomyces hygroscopicus subsp . hygroscopicus SRF1 : a potential biocontrol agent against fusarium wilt with plant growth - promoting abilities in tomatoes. Biocontrol Science and Technology 2024, 34, 389–410. doi:10.1080/09583157.2024.2351810
• Liao, Y.; Wang, X.-J.; Ma, G.-L.; Candra, H.; Qiu En, S. L.; Khandelwal, S.; Liang, Z.-X. Biosynthesis of Octacosamicin A: Uncommon Starter/extender Units and Product Releasing via Intermolecular Amidation. Chembiochem : a European journal of chemical biology 2023, 25, e202300590. doi:10.1002/cbic.202300590
• Hou, A.; Dickschat, J. S. Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides. Natural product reports 2023, 40, 470–499. doi:10.1039/d2np00071g
• Kim, G. J.; Mascuch, S. J.; Mevers, E.; Boudreau, P. D.; Gerwick, W. H.; Choi, H. Luquilloamides, Cytotoxic Lipopeptides from a Puerto Rican Collection of the Filamentous Marine Cyanobacterium Oscillatoria sp. The Journal of organic chemistry 2021, 87, 1043–1055. doi:10.1021/acs.joc.1c02340
• Schwarzer, P.; Tsypik, O.; Zuo, C.; Alali, A.; Wunsch-Palasis, J.; Heitzler, T.; Derochefort, J.; Bernhardt, M.; Yan, X.; Paululat, T.; Bechthold, A. Early Steps in the Biosynthetic Pathway of Rishirilide B. Molecules (Basel, Switzerland) 2020, 25, 1955. doi:10.3390/molecules25081955
• Wang, B.; Ren, H.; Tian, Q.; Zhao, H. Activation of Silent Natural Product Biosynthetic Gene Clusters Using Synthetic Biology Tools. Comprehensive Natural Products III; Elsevier, 2020; pp 113–135. doi:10.1016/b978-0-12-409547-2.14725-0
• Yang, T.; Yamada, K.; Zhou, T.; Harunari, E.; Igarashi, Y.; Terahara, T.; Kobayashi, T.; Imada, C. Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp. The Journal of antibiotics 2019, 72, 202–209. doi:10.1038/s41429-018-0139-7
• Yang, T.; Yamada, K.; Nakayama, J.; Igarashi, Y.
• Wang, B.; Guo, F.; Dong, S.-H.; Zhao, H. Activation of silent biosynthetic gene clusters using transcription factor decoys. Nature chemical biology 2018, 15, 111–114. doi:10.1038/s41589-018-0187-0
• Skiba, M. A.; Sikkema, A. P.; Moss, N. A.; Lowell, A. N.; Su, M.; Sturgis, R. M.; Gerwick, L.; Gerwick, W. H.; Sherman, D. H.; Smith, J. L. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS chemical biology 2018, 13, 1640–1650. doi:10.1021/acschembio.8b00252

Explore citations to this article at