High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine

Scholarly Works

• Wang, Z.; Sheaff, R. J.; Hussaini, S. R. Chloroquine-Based Mitochondrial ATP Inhibitors. Molecules (Basel, Switzerland) 2023, 28, 1161. doi:10.3390/molecules28031161
• Singh, R.; Kumar Tyagi, Y.; Yadav, N. Hydroxychloroquine: Chemistry and Medicinal Applications. HETEROCYCLES 2023, 106, 423. doi:10.3987/rev-22-993
• Chen, Y.; Monbaliu, J. M. doi:10.1002/9783527824595.ch7
• Akwi, F. M.; Watts, P. doi:10.1002/9783527824595.ch6
• Van Praet, S.; Preegel, G.; Rammal, F.; Sels, B. F. One-Pot Consecutive Reductive Amination Synthesis of Pharmaceuticals: From Biobased Glycolaldehyde to Hydroxychloroquine. ACS Sustainable Chemistry & Engineering 2022, 10, 6503–6508. doi:10.1021/acssuschemeng.2c00570
• Chouhan, N. K.; Ananthabhat, S. K.; Vaidya, S.; Srihari, P. A scalable process for the synthesis of key intermediates novoldiamine & hydroxynovaldiamine and their utility in chloroquine, hydroxychloroquine and mepacrine synthesis. Synthetic Communications 2022, 52, 1004–1011. doi:10.1080/00397911.2022.2061358
• Murugan, K.; Panneerselvam, C.; Subramaniam, J.; Paulpandi, M.; Rajaganesh, R.; Vasanthakumaran, M.; Madhavan, J.; Shafi, S. S.; Roni, M.; Portilla-Pulido, J. S.; Mendez, S. C.; Duque, J. E.; Wang, L.; Aziz, A. T.; Chandramohan, B.; Dinesh, D.; Piramanayagam, S.; Hwang, J.-S. Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases. Scientific reports 2022, 12, 4765. doi:10.1038/s41598-022-08397-5
• Malik, P.; Jain, S.; Jain, P.; Kumawat, J.; Dwivedi, J.; Kishore, D. A comprehensive update on the structure and synthesis of potential drug targets for combating the coronavirus pandemic caused by SARS-CoV-2. Archiv der Pharmazie 2022, 355, e2100382–2100382. doi:10.1002/ardp.202100382
• Cue, B. W. Green chemistry approaches to drugs that treat epidemic and pandemic diseases. Contemporary Chemical Approaches for Green and Sustainable Drugs; Elsevier, 2022; pp 307–331. doi:10.1016/b978-0-12-822248-5.00003-6
• Shagufta; Ahmad, I. An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS-CoV-2 Activity. ChemistrySelect 2021, 6, 11502–11527. doi:10.1002/slct.202103301
• Rossi, F. V.; Gentili, D.; Marcantoni, E. Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis. Molecules (Basel, Switzerland) 2021, 26, 2620. doi:10.3390/molecules26092620
• de Souza, A. A. N.; Paez, E. B. A.; de Assis, F. F.; Brocksom, T. J.; de Oliveira, K. T. Improved Synthesis of Bioactive Molecules Through Flow Chemistry. Topics in Medicinal Chemistry; Springer International Publishing, 2021; pp 317–371. doi:10.1007/7355_2021_117
• Domokos, A.; Nagy, B.; Szilagyi, B.; Marosi, G.; Nagy, Z. K. Integrated Continuous Pharmaceutical Technologies—A Review. Organic Process Research & Development 2021, 25, 721–739. doi:10.1021/acs.oprd.0c00504
• Adhikari, B.; Sahu, N. COVID-19 into Chemical Science Perspective: Chemical Preventive Measures and Drug Development. ChemistrySelect 2021, 6, 2010–2028. doi:10.1002/slct.202100127
• Jiao, J.; Nie, W.; Yu, T.; Yang, F.; Zhang, Q.; Aihemaiti, F.; Yang, T.; Liu, X.; Wang, J.; Li, P. Multi-Step Continuous-Flow Organic Synthesis: Opportunities and Challenges. Chemistry (Weinheim an der Bergstrasse, Germany) 2021, 27, 4817–4838. doi:10.1002/chem.202004477
• Li, D.; Hu, J.; Li, D.; Yang, W.; Yin, S.-F.; Qiu, R. Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19. Topics in current chemistry (Cham) 2021, 379, 4. doi:10.1007/s41061-020-00318-2
• Reddy, E. K.; Battula, S.; Anwar; Sajith, A. M. Drug Re-purposing Approach and Potential Therapeutic Strategies to Treat COVID-19. Mini reviews in medicinal chemistry 2021, 21, 704–723. doi:10.2174/1389557520666201113105940
• Batalha, P. N.; da S. M. Forezi, L.; Lima, C. G. S.; Pauli, F. P.; da C. S. Boechat, F.; de Souza, M. C. B. V.; Cunha, A. C.; Ferreira, V. F.; da Silva, F. d. C. Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches. Bioorganic chemistry 2020, 106, 104488. doi:10.1016/j.bioorg.2020.104488
• Hussain, S. M.; Kumar, R.; Ali, M. M. N.; Kannappan, V. Steric effect in the formation of hydrogen bonded complexes of isopropylamine with alicyclic ethers by ultrasonic and DFT approach. Journal of Molecular Liquids 2020, 317, 113910. doi:10.1016/j.molliq.2020.113910
• Al Bujuq, N. Methods of Synthesis of Remdesivir, Favipiravir, Hydroxychloroquine, and Chloroquine: Four Small Molecules Repurposed for Clinical Trials during the Covid-19 Pandemic. Synthesis 2020, 52, 3735–3750. doi:10.1055/s-0040-1707386

Explore citations to this article at